NCKIPSD (NCK interacting protein with SH3 domain)
2000-02-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
3p21.31
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
AF3P21,DIP,DIP1,ORF1,SPIN90,VIP54,WASLBP,WISH
FUSION GENES
DNA/RNA
Description
2990 bp cDNA
Proteins
Expression
wide
Implicated in
Entity name
Disease
treatment related acute non lymphoblastic leukemia (t-AML)
Hybrid gene
5 prime MLL-3 prime AF3q21
Fusion protein
AT hooks and methyltransferase domains of MLL in the N-term fused to the proline-rich domain and nuclear localization signal of AF3p21
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10381517 | 1999 | Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations. | Fioretos T et al |
Other Information
Locus ID:
NCBI: 51517
MIM: 606671
HGNC: 15486
Ensembl: ENSG00000213672
Variants:
dbSNP: 51517
ClinVar: 51517
TCGA: ENSG00000213672
COSMIC: NCKIPSD
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31358736 | 2019 | SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis. | 5 |
| 31358736 | 2019 | SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis. | 5 |
| 30322896 | 2018 | Structure of the nucleation-promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex. | 20 |
| 30322896 | 2018 | Structure of the nucleation-promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex. | 20 |
| 28652253 | 2017 | SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression. | 16 |
| 28652253 | 2017 | SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression. | 16 |
| 23342115 | 2013 | SPIN90 phosphorylation modulates spine structure and synaptic function. | 9 |
| 23765104 | 2013 | SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons. | 9 |
| 24340049 | 2013 | SPIN90 knockdown attenuates the formation and movement of endosomal vesicles in the early stages of epidermal growth factor receptor endocytosis. | 9 |
| 23342115 | 2013 | SPIN90 phosphorylation modulates spine structure and synaptic function. | 9 |
| 23765104 | 2013 | SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons. | 9 |
| 24340049 | 2013 | SPIN90 knockdown attenuates the formation and movement of endosomal vesicles in the early stages of epidermal growth factor receptor endocytosis. | 9 |
| 23024796 | 2012 | Dia-interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices. | 13 |
| 23024796 | 2012 | Dia-interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices. | 13 |
| 19460367 | 2009 | SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling. | 8 |
Citation
Jean-Loup Huret
NCKIPSD (NCK interacting protein with SH3 domain)
Atlas Genet Cytogenet Oncol Haematol. 2000-02-01
Online version: http://atlasgeneticsoncology.org/gene/228/nckipsd
