FOXO3 (forkhead box O3A)

1998-04-01   Olivier Bernard 

Unite Inserm U434, CNRS, Institut de Genetique Moleculaire, Paris, France

Identity

HGNC
LOCATION
6q21
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
AF6q21,FKHRL1,FKHRL1P2,FOXO2,FOXO3A
FUSION GENES

DNA/RNA

Transcription

6 kb transcript with a 3.2 kb mRNA complete cds; coding sequence: CDS 925..2946

Proteins

Atlas Image

Description

673 amino acids; NH2 -- similarity region with AFX and FKHR -- Forkhead motif -- COOH

Expression

wide

Localisation

nuclear (potential)

Function

may be a transcription regulator

Homology

AFX, involved in the t(X;11)(q13;q23), and FHKR, involved in rabdomyosarcoma; with also a similar breakpoint location within the forkhead motif

Implicated in

Entity name
Disease
treatment related AML, M5 type
Hybrid gene
5 MLL - 3 AF6q2
Fusion protein
240 kDa protein with about 1400 amino acids from N-term MLL fused to 446 amino acids from AF6q21 C-term; the reciprocal may be expressed

Bibliography

Pubmed IDLast YearTitleAuthors
94794911998Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.Anderson MJ et al
93450571997AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily.Hillion J et al

Other Information

Locus ID:

NCBI: 2309
MIM: 602681
HGNC: 3821
Ensembl: ENSG00000118689

Variants:

dbSNP: 2309
ClinVar: 2309
TCGA: ENSG00000118689
COSMIC: FOXO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118689ENST00000343882O43524
ENSG00000118689ENST00000406360O43524
ENSG00000118689ENST00000540898O43524

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Endometrial cancerKEGGko05213
Non-small cell lung cancerKEGGko05223
Endometrial cancerKEGGhsa05213
Non-small cell lung cancerKEGGhsa05223
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
FoxO signaling pathwayKEGGhsa04068
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
PI3K-Akt signalingKEGGhsa_M00676
PI3K-Akt signalingKEGGM00676
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
PI3K/AKT Signaling in CancerREACTOMER-HSA-2219528
Constitutive Signaling by AKT1 E17K in CancerREACTOMER-HSA-5674400
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
AKT phosphorylates targets in the nucleusREACTOMER-HSA-198693
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150
Longevity regulating pathwayKEGGhsa04211
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187658032008FOXO3A genotype is strongly associated with human longevity.359
268616252016Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.349
177118462007The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.291
182044392008ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.267
191969702009Association of FOXO3A variation with human longevity confirmed in German centenarians.239
191969702009Association of FOXO3A variation with human longevity confirmed in German centenarians.239
217081912011FoxO transcription factors; Regulation by AKT and 14-3-3 proteins.221
191885902009Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor.216
161005712005Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.193
145279512003FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.176

Citation

Olivier Bernard

FOXO3 (forkhead box O3A)

Atlas Genet Cytogenet Oncol Haematol. 1998-04-01

Online version: http://atlasgeneticsoncology.org/gene/125/foxo3