Atlas of Genetics and Cytogenetics in Oncology and Haematology
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
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FOXO3 (forkhead box O3A)
| Identity |
| Other names | AF6q21 (ALL1 fused gene from chromosome 6q21) |
| FKHRL1 (forkhead homolog rhabdomyosarcoma like 1) | |
| HGNC (Hugo) | FOXO3 |
| LocusID (NCBI) | 2309 |
| Location | 6q21 |
| Location_base_pair | Starts at 108882069 and ends at 109005971 bp from pter ( according to hg19-Feb_2009) [Mapping] |
 | |
| Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics | |
| DNA/RNA |
| Transcription | 6 kb transcript with a 3.2 kb mRNA complete cds; coding sequence: CDS 925..2946 |
| Protein |
 | |
| Description | 673 amino acids; NH2 -- similarity region with AFX and FKHR -- Forkhead motif -- COOH |
| Expression | wide |
| Localisation | nuclear (potential) |
| Function | may be a transcription regulator |
| Homology | AFX, involved in the t(X;11)(q13;q23), and FHKR, involved in rabdomyosarcoma; with also a similar breakpoint location within the forkhead motif |
| Implicated in |
| Entity | t(6;11)(q21;q23)/ANLL --> MLL - AF6q21 |
| Disease | treatment related ANLL, M5 type |
| Hybrid/Mutated Gene | 5' MLL - 3' AF6q2 |
| Abnormal Protein | 240 kDa protein with about 1400 amino acids from N-term MLL fused to 446 amino acids from AF6q21 C-term; the reciprocal may be expressed |
| Other Leukemias implicated (Data extracted from papers in the Atlas) |
| Leukemias | 11q23ChildAMLID1615 | 11q23ID1030 |
| External links |
| Bibliography |
| AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. |
| Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA |
| Blood. 1997 ; 90 (9) : 3714-3719. |
| PMID 9345057 |
| Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. |
| Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC |
| Genomics. 1998 ; 47 (2) : 187-199. |
| PMID 9479491 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 04-1998 | Olivier Bernard |
| Citation |
| This paper should be referenced as such : |
| Bernard, O |
| FOXO3A (forkhead box O3A) |
| Atlas Genet Cytogenet Oncol Haematol. 1998;2(3):73-73. |
| Free journal version : [ pdf ] [ DOI ] |
| URL : http://AtlasGeneticsOncology.org/Genes/AF6q21ID125.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Feb 17 20:09:47 CET 2015 |
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