Fusion genes
(updated 2016) | FOXO3 (6q21) / CHD7 (8q12.2) | FOXO3 (6q21) / FOXN3 (14q31.3) | FOXO3 (6q21) / KMT2A (11q23.3) |
| |
FOXO3 (6q21) / SEPT1 (16p11.2) | GSN (9q33.2) / FOXO3 (6q21) | KMT2A (11q23.3) / FOXO3 (6q21) |
| |
NEMF (14q21.3) / FOXO3 (6q21) | PPM1G (2p23.3) / FOXO3 (6q21) | TAT (16q22.2) / FOXO3 (6q21) |
| |
| Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. |
| Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC |
| Genomics. 1998 ; 47 (2) : 187-199. |
| PMID 9479491 |
| |
| AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. |
| Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA |
| Blood. 1997 ; 90 (9) : 3714-3719. |
| PMID 9345057 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | FOXO3 3821 |
| Cards |
|---|
| Atlas | AF6q21ID125 |
| Entrez_Gene (NCBI) | FOXO3 2309 forkhead box O3 |
| Aliases | AF6q21; FKHRL1; FKHRL1P2; FOXO2; |
| FOXO3A |
| GeneCards (Weizmann) | FOXO3 |
| Ensembl hg19 (Hinxton) | ENSG00000118689 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000118689 [Gene_View] chr6:108560866-108684768 [Contig_View] FOXO3 [Vega] |
| ICGC DataPortal | ENSG00000118689 |
| TCGA cBioPortal | FOXO3 |
| AceView (NCBI) | FOXO3 |
| Genatlas (Paris) | FOXO3 |
| WikiGenes | 2309 |
| SOURCE (Princeton) | FOXO3 |
| Genetics Home Reference (NIH) | FOXO3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | FOXO3 - chr6:108560866-108684768 + 6q21 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | FOXO3 - 6q21 [Description] (hg19-Feb_2009) |
| Ensembl | FOXO3 - 6q21 [CytoView hg19] FOXO3 - 6q21 [CytoView hg38] |
| Mapping of homologs : NCBI | FOXO3 [Mapview hg19] FOXO3 [Mapview hg38] |
| OMIM | 602681 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB072905 AF032886 AI554317 AJ001589 AK024103 |
| RefSeq transcript (Entrez) | NM_001455 NM_201559 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | FOXO3 |
| Cluster EST : Unigene | Hs.220950 [ NCBI ] |
| CGAP (NCI) | Hs.220950 |
| Alternative Splicing Gallery | ENSG00000118689 |
| Gene Expression | FOXO3 [ NCBI-GEO ] FOXO3 [ EBI - ARRAY_EXPRESS ]
FOXO3 [ SEEK ] FOXO3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FOXO3 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 2309 |
| GTEX Portal (Tissue expression) | FOXO3 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O43524 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O43524 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O43524 |
| Splice isoforms : SwissVar | O43524 |
| PhosPhoSitePlus | O43524 |
| Domaine pattern : Prosite (Expaxy) | FORK_HEAD_2 (PS00658) FORK_HEAD_3 (PS50039) |
| Domains : Interpro (EBI) | Fork_head_dom FOXO-TAD FOXO_KIX-bd TF_fork_head_CS_2 WHTH_DNA-bd_dom |
| Domain families : Pfam (Sanger) | Forkhead (PF00250) FOXO-TAD (PF16676) FOXO_KIX_bdg (PF16675) |
| Domain families : Pfam (NCBI) | pfam00250 pfam16676 pfam16675 |
| Domain families : Smart (EMBL) | FH (SM00339) |
| Conserved Domain (NCBI) | FOXO3 |
| DMDM Disease mutations | 2309 |
| Blocks (Seattle) | FOXO3 |
| PDB (SRS) | 2K86 2LQH 2LQI 2UZK |
| PDB (PDBSum) | 2K86 2LQH 2LQI 2UZK |
| PDB (IMB) | 2K86 2LQH 2LQI 2UZK |
| PDB (RSDB) | 2K86 2LQH 2LQI 2UZK |
| Structural Biology KnowledgeBase | 2K86 2LQH 2LQI 2UZK |
| SCOP (Structural Classification of Proteins) | 2K86 2LQH 2LQI 2UZK |
| CATH (Classification of proteins structures) | 2K86 2LQH 2LQI 2UZK |
| Superfamily | O43524 |
| Human Protein Atlas | ENSG00000118689 |
| Peptide Atlas | O43524 |
| HPRD | 04061 |
| IPI | IPI00878632 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O43524 |
| IntAct (EBI) | O43524 |
| FunCoup | ENSG00000118689 |
| BioGRID | FOXO3 |
| STRING (EMBL) | FOXO3 |
| ZODIAC | FOXO3 |
| Ontologies - Pathways |
|---|
| QuickGO | O43524 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter core promoter binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nucleoplasm cytoplasm mitochondrion cytosol cytosol regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of translation aging beta-catenin binding membrane protein kinase binding DNA damage response, signal transduction by p53 class mediator chromatin DNA binding response to nutrient levels tumor necrosis factor-mediated signaling pathway cellular response to oxidative stress response to drug positive regulation of apoptotic process positive regulation of neuron apoptotic process sequence-specific DNA binding positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter brain morphogenesis cellular response to glucose stimulus cellular response to corticosterone stimulus cellular response to hypoxia response to dexamethasone negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of reactive oxygen species biosynthetic process cellular response to beta-amyloid cellular response to nerve growth factor stimulus response to water-immersion restraint stress regulation of neural precursor cell proliferation positive regulation of endothelial cell apoptotic process |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter core promoter binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nucleoplasm cytoplasm mitochondrion cytosol cytosol regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of translation aging beta-catenin binding membrane protein kinase binding DNA damage response, signal transduction by p53 class mediator chromatin DNA binding response to nutrient levels tumor necrosis factor-mediated signaling pathway cellular response to oxidative stress response to drug positive regulation of apoptotic process positive regulation of neuron apoptotic process sequence-specific DNA binding positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter brain morphogenesis cellular response to glucose stimulus cellular response to corticosterone stimulus cellular response to hypoxia response to dexamethasone negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of reactive oxygen species biosynthetic process cellular response to beta-amyloid cellular response to nerve growth factor stimulus response to water-immersion restraint stress regulation of neural precursor cell proliferation positive regulation of endothelial cell apoptotic process |
| Pathways : BIOCARTA | Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Genes] PTEN dependent cell cycle arrest and apoptosis [Genes] The IGF-1 Receptor and Longevity [Genes] AKT Signaling Pathway [Genes] |
| Pathways : KEGG | Chemokine signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Neurotrophin signaling pathway Prolactin signaling pathway Endometrial cancer Non-small cell lung cancer |
| NDEx Network | FOXO3 |
| Atlas of Cancer Signalling Network | FOXO3 |
| Wikipedia pathways | FOXO3 |
| Orthology - Evolution |
|---|
| OrthoDB | 2309 |
| GeneTree (enSembl) | ENSG00000118689 |
| Phylogenetic Trees/Animal Genes : TreeFam | FOXO3 |
| HOVERGEN | O43524 |
| HOGENOM | O43524 |
| Homologs : HomoloGene | FOXO3 |
| Homology/Alignments : Family Browser (UCSC) | FOXO3 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | FOXO3/CHD7 [6q21/8q12.1] |
| Fusion : COSMIC | KMT2A [11q23.3] - FOXO3 [6q21] [fusion_1795] [fusion_1796] [fusion_1813] [fusion_1814] |
| Fusion: TCGA | FOXO3 6q21 CHD7 8q12.1 BRCA |
| Fusion : TICdb | KMT2A [11q23.3] - FOXO3 [6q21] |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | FOXO3 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | FOXO3 |
| dbVar | FOXO3 |
| ClinVar | FOXO3 |
| 1000_Genomes | FOXO3 |
| Exome Variant Server | FOXO3 |
| ExAC (Exome Aggregation Consortium) | FOXO3 (select the gene name) |
| Genetic variants : HAPMAP | 2309 |
| Genomic Variants (DGV) | FOXO3 [DGVbeta] |
| DECIPHER | FOXO3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | FOXO3 |
| Mutations |
|---|
| ICGC Data Portal | FOXO3 |
| TCGA Data Portal | FOXO3 |
| Broad Tumor Portal | FOXO3 |
| OASIS Portal | FOXO3 [ Somatic mutations - Copy number] |
| Cancer Gene: Census | FOXO3 |
| Somatic Mutations in Cancer : COSMIC | FOXO3 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | FOXO3 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search FOXO3 |
| DgiDB (Drug Gene Interaction Database) | FOXO3 |
| DoCM (Curated mutations) | FOXO3 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FOXO3 (select a term) |
| intoGen | FOXO3 |
| NCG5 (London) | FOXO3 |
| Cancer3D | FOXO3(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602681 |
| Orphanet | |
| Medgen | FOXO3 |
| Genetic Testing Registry | FOXO3
|
| NextProt | O43524 [Medical] |
| TSGene | 2309 |
| GENETests | FOXO3 |
| Target Validation | FOXO3 |
| Huge Navigator |
FOXO3 [HugePedia] |
| snp3D : Map Gene to Disease | 2309 |
| BioCentury BCIQ | FOXO3 |
| ClinGen | FOXO3 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 2309 |
| Chemical/Pharm GKB Gene | PA28239 |
| Clinical trial | FOXO3 |
| Miscellaneous |
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| canSAR (ICR) | FOXO3 (select the gene name) |
| Probes |
|---|
| Litterature |
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| PubMed | 448 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | FOXO3 |
| EVEX | FOXO3 |
| GoPubMed | FOXO3 |
| iHOP | FOXO3 |
