Atlas of Genetics and Cytogenetics in Oncology and Haematology
FOXO3 (forkhead box O3A)
| Identity |
| Other names | AF6q21 (ALL1 fused gene from chromosome 6q21) |
| FKHRL1 (forkhead homolog rhabdomyosarcoma like 1) | |
| HGNC (Hugo) | FOXO3 |
| LocusID (NCBI) | 2309 |
| Location | 6q21 |
| Location_base_pair | Starts at 108882069 and ends at 109005971 bp from pter ( according to hg19-Feb_2009) [Mapping] |
 | |
| Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics | |
| DNA/RNA |
| Transcription | 6 kb transcript with a 3.2 kb mRNA complete cds; coding sequence: CDS 925..2946 |
| Protein |
| Description | 673 amino acids; NH2 -- similarity region with AFX and FKHR -- Forkhead motif -- COOH |
| Expression | wide |
| Localisation | nuclear (potential) |
| Function | may be a transcription regulator |
| Homology | AFX, involved in the t(X;11)(q13;q23), and FHKR, involved in rabdomyosarcoma; with also a similar breakpoint location within the forkhead motif |
| Implicated in |
| Entity | t(6;11)(q21;q23)/ANLL --> MLL - AF6q21 |
| Disease | treatment related ANLL, M5 type |
| Hybrid/Mutated Gene | 5' MLL - 3' AF6q2 |
| Abnormal Protein | 240 kDa protein with about 1400 amino acids from N-term MLL fused to 446 amino acids from AF6q21 C-term; the reciprocal may be expressed |
| Other Leukemias implicated (Data extracted from papers in the Atlas) |
| Leukemias | t0817q24q22ID1494 | t1119q23p13ID1540 |
| External links |
| Bibliography |
| AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. |
| Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA |
| Blood. 1997 ; 90 (9) : 3714-3719. |
| PMID 9345057 |
| Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. |
| Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC |
| Genomics. 1998 ; 47 (2) : 187-199. |
| PMID 9479491 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 04-1998 | Olivier Bernard |
| Citation |
| This paper should be referenced as such : |
| Bernard, O |
| FOXO3A (forkhead box O3A) |
| Atlas Genet Cytogenet Oncol Haematol. 1998;2(3):73-73. |
| Free online version Free pdf version [Bibliographic record ] |
| URL : http://AtlasGeneticsOncology.org/Genes/AF6q21ID125.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Jul 21 11:31:21 CEST 2014 |
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