| | FOXO3 (6q21) / CHD7 (8q12.2) | FOXO3 (6q21) / FOXN3 (14q31.3) | FOXO3 (6q21) / KMT2A (11q23.3) |
| |
FOXO3 (6q21) / SEPT1 (16p11.2) | GSN (9q33.2) / FOXO3 (6q21) | KMT2A (11q23.3) / FOXO3 (6q21) |
| |
NEMF (14q21.3) / FOXO3 (6q21) | PPM1G (2p23.3) / FOXO3 (6q21) | TAT (16q22.2) / FOXO3 (6q21) |
| |
| Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. |
| Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC |
| Genomics. 1998 ; 47 (2) : 187-199. |
| PMID 9479491 |
| |
| AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. |
| Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA |
| Blood. 1997 ; 90 (9) : 3714-3719. |
| PMID 9345057 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | FOXO3 3821 |
| Cards |
|---|
| Atlas | AF6q21ID125 |
| Entrez_Gene (NCBI) | FOXO3 2309 forkhead box O3 |
| Aliases | AF6q21; FKHRL1; FKHRL1P2; FOXO2; |
| FOXO3A |
| GeneCards (Weizmann) | FOXO3 |
| Ensembl hg19 (Hinxton) | ENSG00000118689 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000118689 [Gene_View] ENSG00000118689 [Sequence] chr6:108559823-108684768 [Contig_View] FOXO3 [Vega] |
| ICGC DataPortal | ENSG00000118689 |
| TCGA cBioPortal | FOXO3 |
| AceView (NCBI) | FOXO3 |
| Genatlas (Paris) | FOXO3 |
| WikiGenes | 2309 |
| SOURCE (Princeton) | FOXO3 |
| Genetics Home Reference (NIH) | FOXO3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | FOXO3 - chr6:108559823-108684768 + 6q21 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | FOXO3 - 6q21 [Description] (hg19-Feb_2009) |
| GoldenPath | FOXO3 - 6q21 [CytoView hg19] FOXO3 - 6q21 [CytoView hg38] |
| ImmunoBase | ENSG00000118689 |
| Mapping of homologs : NCBI | FOXO3 [Mapview hg19] FOXO3 [Mapview hg38] |
| OMIM | 602681 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB072905 AF032886 AI554317 AJ001589 AK024103 |
| RefSeq transcript (Entrez) | NM_001455 NM_201559 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | FOXO3 |
| Cluster EST : Unigene | Hs.220950 [ NCBI ] |
| CGAP (NCI) | Hs.220950 |
| Alternative Splicing Gallery | ENSG00000118689 |
| Gene Expression | FOXO3 [ NCBI-GEO ] FOXO3 [ EBI - ARRAY_EXPRESS ]
FOXO3 [ SEEK ] FOXO3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FOXO3 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 2309 |
| GTEX Portal (Tissue expression) | FOXO3 |
| Human Protein Atlas | ENSG00000118689-FOXO3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O43524 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O43524 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O43524 |
| Splice isoforms : SwissVar | O43524 |
| PhosPhoSitePlus | O43524 |
| Domaine pattern : Prosite (Expaxy) | FORK_HEAD_2 (PS00658) FORK_HEAD_3 (PS50039) |
| Domains : Interpro (EBI) | Fork_head_dom FOXO-TAD FOXO_KIX-bd TF_fork_head_CS_2 WH-like_DNA-bd_sf WH_DNA-bd_sf |
| Domain families : Pfam (Sanger) | Forkhead (PF00250) FOXO-TAD (PF16676) FOXO_KIX_bdg (PF16675) |
| Domain families : Pfam (NCBI) | pfam00250 pfam16676 pfam16675 |
| Domain families : Smart (EMBL) | FH (SM00339) |
| Conserved Domain (NCBI) | FOXO3 |
| DMDM Disease mutations | 2309 |
| Blocks (Seattle) | FOXO3 |
| PDB (RSDB) | 2K86 2LQH 2LQI 2UZK |
| PDB Europe | 2K86 2LQH 2LQI 2UZK |
| PDB (PDBSum) | 2K86 2LQH 2LQI 2UZK |
| PDB (IMB) | 2K86 2LQH 2LQI 2UZK |
| Structural Biology KnowledgeBase | 2K86 2LQH 2LQI 2UZK |
| SCOP (Structural Classification of Proteins) | 2K86 2LQH 2LQI 2UZK |
| CATH (Classification of proteins structures) | 2K86 2LQH 2LQI 2UZK |
| Superfamily | O43524 |
| Human Protein Atlas [tissue] | ENSG00000118689-FOXO3 [tissue] |
| Peptide Atlas | O43524 |
| HPRD | 04061 |
| IPI | IPI00878632 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O43524 |
| IntAct (EBI) | O43524 |
| FunCoup | ENSG00000118689 |
| BioGRID | FOXO3 |
| STRING (EMBL) | FOXO3 |
| ZODIAC | FOXO3 |
| Ontologies - Pathways |
|---|
| QuickGO | O43524 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription cofactor binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm mitochondrion mitochondrial outer membrane mitochondrial matrix cytosol cytosol regulation of transcription by RNA polymerase II mitochondrial transcription regulation of translation aging beta-catenin binding transcription factor binding insulin receptor signaling pathway positive regulation of autophagy positive regulation of muscle atrophy cytokine-mediated signaling pathway protein kinase binding DNA damage response, signal transduction by p53 class mediator negative regulation of cell migration chromatin DNA binding protein-containing complex tumor necrosis factor-mediated signaling pathway mitochondrial sequence-specific DNA-binding transcription factor activity cellular response to oxidative stress glucose homeostasis response to starvation positive regulation of apoptotic process positive regulation of neuron apoptotic process sequence-specific DNA binding sequence-specific DNA binding positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II brain morphogenesis cellular response to glucose stimulus cellular response to corticosterone stimulus cellular response to hypoxia response to dexamethasone negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of reactive oxygen species biosynthetic process cellular response to amyloid-beta cellular response to nerve growth factor stimulus response to water-immersion restraint stress regulation of neural precursor cell proliferation positive regulation of endothelial cell apoptotic process |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription cofactor binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm mitochondrion mitochondrial outer membrane mitochondrial matrix cytosol cytosol regulation of transcription by RNA polymerase II mitochondrial transcription regulation of translation aging beta-catenin binding transcription factor binding insulin receptor signaling pathway positive regulation of autophagy positive regulation of muscle atrophy cytokine-mediated signaling pathway protein kinase binding DNA damage response, signal transduction by p53 class mediator negative regulation of cell migration chromatin DNA binding protein-containing complex tumor necrosis factor-mediated signaling pathway mitochondrial sequence-specific DNA-binding transcription factor activity cellular response to oxidative stress glucose homeostasis response to starvation positive regulation of apoptotic process positive regulation of neuron apoptotic process sequence-specific DNA binding sequence-specific DNA binding positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II brain morphogenesis cellular response to glucose stimulus cellular response to corticosterone stimulus cellular response to hypoxia response to dexamethasone negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of reactive oxygen species biosynthetic process cellular response to amyloid-beta cellular response to nerve growth factor stimulus response to water-immersion restraint stress regulation of neural precursor cell proliferation positive regulation of endothelial cell apoptotic process |
| Pathways : KEGG | Chemokine signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Neurotrophin signaling pathway Prolactin signaling pathway Endometrial cancer Non-small cell lung cancer |
| NDEx Network | FOXO3 |
| Atlas of Cancer Signalling Network | FOXO3 |
| Wikipedia pathways | FOXO3 |
| Orthology - Evolution |
|---|
| OrthoDB | 2309 |
| GeneTree (enSembl) | ENSG00000118689 |
| Phylogenetic Trees/Animal Genes : TreeFam | FOXO3 |
| HOGENOM | O43524 |
| Homologs : HomoloGene | FOXO3 |
| Homology/Alignments : Family Browser (UCSC) | FOXO3 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | FOXO3/CHD7 [6q21/8q12.1] |
| Fusion : COSMIC | KMT2A [11q23.3] - FOXO3 [6q21] [fusion_1795] [fusion_1796] [fusion_1813] [fusion_1814] |
| Fusion Portal | FOXO3 6q21 CHD7 8q12.1 BRCA |
| Fusion : TICdb | KMT2A [11q23.3] - FOXO3 [6q21] |
| Fusion : FusionGDB | 13821 13822 13823 13824 15559 24038 28241 28388 |
| Fusion : Fusion_Hub | FOXO3--ARID1B FOXO3--ARMC2 FOXO3--CAMTA1 FOXO3--CHD7 FOXO3--FOXN3 FOXO3--FXR1 FOXO3--FYN FOXO3--GPR133 FOXO3--GPR6 FOXO3--IMMP2L FOXO3--IPCEF1 FOXO3--KMT2A FOXO3--LACE1 FOXO3--LINC00222 FOXO3--LYZ |
| FOXO3--MICAL1 FOXO3--MLL FOXO3--MORF4L2 FOXO3--MYC FOXO3--NT5DC1 FOXO3--PDSS2 FOXO3--PPP1R9A FOXO3--PSMB1 FOXO3--RERE FOXO3--RNF146 FOXO3--SEPT1 FOXO3--SESN1 FOXO3--SNX3 FOXO3--ZNF462 GSN--FOXO3 |
| HSPH1--FOXO3 ISCU--FOXO3 KMT2A--FOXO3 MLL--FOXO3 NEMF--FOXO3 PPM1G--FOXO3 REPS1--FOXO3 SSH1--FOXO3 |
| Fusion : Quiver | FOXO3 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | FOXO3 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | FOXO3 |
| dbVar | FOXO3 |
| ClinVar | FOXO3 |
| 1000_Genomes | FOXO3 |
| Exome Variant Server | FOXO3 |
| ExAC (Exome Aggregation Consortium) | ENSG00000118689 |
| GNOMAD Browser | ENSG00000118689 |
| Varsome Browser | FOXO3 |
| Genetic variants : HAPMAP | 2309 |
| Genomic Variants (DGV) | FOXO3 [DGVbeta] |
| DECIPHER | FOXO3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | FOXO3 |
| Mutations |
|---|
| ICGC Data Portal | FOXO3 |
| TCGA Data Portal | FOXO3 |
| Broad Tumor Portal | FOXO3 |
| OASIS Portal | FOXO3 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | FOXO3 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | FOXO3 |
| Mutations and Diseases : HGMD | FOXO3 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search FOXO3 |
| DgiDB (Drug Gene Interaction Database) | FOXO3 |
| DoCM (Curated mutations) | FOXO3 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FOXO3 (select a term) |
| intoGen | FOXO3 |
| NCG5 (London) | FOXO3 |
| Cancer3D | FOXO3(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602681 |
| Orphanet | |
| DisGeNET | FOXO3 |
| Medgen | FOXO3 |
| Genetic Testing Registry | FOXO3
|
| NextProt | O43524 [Medical] |
| TSGene | 2309 |
| GENETests | FOXO3 |
| Target Validation | FOXO3 |
| Huge Navigator |
FOXO3 [HugePedia] |
| snp3D : Map Gene to Disease | 2309 |
| BioCentury BCIQ | FOXO3 |
| ClinGen | FOXO3 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 2309 |
| Chemical/Pharm GKB Gene | PA28239 |
| Clinical trial | FOXO3 |
| Miscellaneous |
|---|
| canSAR (ICR) | FOXO3 (select the gene name) |
| DataMed Index | FOXO3 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | FOXO3 |
| EVEX | FOXO3 |
| GoPubMed | FOXO3 |
| iHOP | FOXO3 |
