CIP29 (cytokine induced protein 29 kDa)

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CIP29 (cytokine induced protein 29 kDa)

Identity

Other names	HCC-1
HGNC (Hugo)
Location	12q13
Location_base_pair	Starts at 56151054 and ends at 56211540 bp from pter ( according to hg19-Feb_2009)
Note	HCC-1 is an alias for CIP29 (12q13), but also for CCL14 (17q11.2)

Protein

Description	210 amino acids, 29 kDa;contains from N term to C term a SAP domain and 2 nuclear localization domains, and also 3 possible N-glycosylation sites and 9 potential phosphorylation sites. A SAP domain is a putative DNA binding motif involved in chromosomal organization and may regulate transcription, DNA repair, RNA processing.
Expression	Widely expressed in fetal and adult tissues, as well as cancer cell lines; upregulated by EPO (erythropoietin), TPO (thrombopoietin), FL (FLT3 Ligand), and SCF (stem cell factor). Associated with cell cycle progression
Localisation	Nucleus but some staining was also found in the cytoplasm.

Implicated in

Entity	M4 acute non lymphocytic leukaemia (ANLL) with t(11;12)(q23;q13) --> (MLL/CIP29)
Note	only one case to date
Prognosis	unknown
Hybrid/Mutated Gene	5' MLL - 3' CIP29 including the 9 first exons of MLL, and nearly the entire CIP29
Abnormal Protein	The fusion protein includes from N term to C term the AT hooks and the methyltransferase domain of MLL and the SAP domain and the C term nuclear localization domains of CIP29.

External links

	Nomenclature
HGNC (Hugo)	SARNP 24432
Entrez_Gene (NCBI)	SARNP 84324 SAP domain containing ribonucleoprotein
	Cards
Atlas	CIP29ID42967ch12q13
GeneCards (Weizmann)	SARNP
Ensembl (Hinxton)	ENSG00000205323 [Gene_View] chr12:56151054-56211540 [Contig_View] SARNP [Vega]
AceView (NCBI)	SARNP
Genatlas (Paris)	SARNP
euGene (Indiana)	84324
SOURCE (Stanford)	NM_033082
	Genomic and cartography
GoldenPath (UCSC)	SARNP - 12q13 chr12:56151054-56211540 - 12q13.2 [Description] (hg19-Feb_2009)
Ensembl	SARNP - 12q13.2 [CytoView]
Mapping of homologs : NCBI	SARNP [Mapview]
OMIM	610049
	Gene and transcription
Genbank (Entrez)	AF161434 AF486281 AK222719 AK290508 BC007099
RefSeq transcript (SRS)	NM_033082
RefSeq transcript (Entrez)	NM_033082
RefSeq genomic (SRS)	AC_000144 NC_000012 NT_029419 NW_001838059
RefSeq genomic (Entrez)	AC_000144 NC_000012 NT_029419 NW_001838059
Consensus coding sequences : CCDS (NCBI)	SARNP
Cluster EST : Unigene	Hs.505676 [ SRS ] Hs.505676 [ NCBI ]
Alternative Splicing Gallery	ENSG00000205323
Gene Expression	SARNP [ NCBI-GEO ] SARNP [ EBI - ARRAY_EXPRESS ]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P82979 (SRS) P82979 (Uniprot)
With graphics : InterPro	P82979
Splice isoforms : SwissVar	P82979(Swissvar)
Domaine pattern : Prosite (SRS)	SAP (PS50800)
Domaine pattern : Prosite (Expaxy)	SAP (PS50800)
Domains : Interpro (SRS)	SAP_DNA-bd
Domains : Interpro (EBI)	SAP_DNA-bd
Related proteins : CluSTr	P82979
Domain families : Pfam (SRS)	SAP (PF02037)
Domain families : Pfam (Sanger)	SAP (PF02037)
Domain families : Pfam (NCBI)	pfam02037
Domain families : Smart (EMBL)	SAP (SM00513)
Blocks (Seattle)	P82979
PDB (SRS)	2DO1
PDB (PDBSum)	2DO1
PDB (IMB)	2DO1
PDB (RSDB)	2DO1
Human Protein Atlas	ENSG00000205323
HPRD	16716
IPI	IPI00014938 IPI01015600 IPI01022436 IPI01021985
dbDEPC	IPI00014938
	Protein Interaction databases
DIP (DOE-UCLA)	P82979
IntAct (EBI)	P82979
FunCoup	ENSG00000205323
REACTOME	SARNP
BioGRID	SARNP
InParanoid	P82979
Interologous Interaction database	P82979
	Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)	SARNP
SNP (GeneSNP Utah)	SARNP
SNP : HGBase	SARNP
Genetic variants : HAPMAP	SARNP
Somatic Mutations in Cancer : COSMIC	SARNP
CONAN: Copy Number Analysis	SARNP
Mutations and Diseases : HGMD	SARNP
OMIM	610049
GENETests	610049
Disease Genetic Association	SARNP
Huge Navigator	SARNP [HugePedia] SARNP [HugeCancerGEM]
Genomic Variants	SARNP
snp3D : Map Gene to Disease
	General knowledge
Homologs : HomoloGene	SARNP
Homology/Alignments : Family Browser (UCSC)	SARNP
Phylogenetic Trees/Animal Genes : TreeFam	SARNP
Chemical/Protein Interactions : CTD	84324
Chemical/Pharm GKB Gene	PA165513309
Clinical trial	SARNP
Cancer Resource (Charite)	ENSG00000205323
Ontology : AmiGO	nucleic acid binding DNA binding RNA binding nucleus nucleus nucleolus regulation of transcription, DNA-dependent regulation of translation protein C-terminus binding RS domain binding
Ontology : EGO-EBI	nucleic acid binding DNA binding RNA binding nucleus nucleus nucleolus regulation of transcription, DNA-dependent regulation of translation protein C-terminus binding RS domain binding
	Other databases
	Probes
	Litterature
PubMed	23 Pubmed reference(s) in Entrez
PubGene	SARNP
iHOP	SARNP

Bibliography

Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29.

Fukuda S, Wu DW, Stark K, Pelus LM

Biochemical and biophysical research communications. 2002 ; 292 (3) : 593-600.

PMID 11922608

A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia.

Hashii Y, Kim JY, Sawada A, Tokimasa S, Hiroyuki F, Ohta H, Makiko K, Takihara Y, Ozono K, Hara J

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2004 ; 18 (9) : 1546-1548.

PMID 15284855

Growth inhibitory effect of Hcc-1/CIP29 is associated with induction of apoptosis, not just with G2/M arrest.

Fukuda S, Pelus LM

Cellular and molecular life sciences : CMLS. 2005 ; 62 (13) : 1526-1527.

PMID 15924260

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	08-2005	Jean Loup Huret, Sylvie Senon

Citation
This paper should be referenced as such :
Huret JL, Senon S . CIP29 (cytokine induced protein 29 kDa). Atlas Genet Cytogenet Oncol Haematol. August 2005 .
URL : http://AtlasGeneticsOncology.org/Genes/CIP29ID42967ch12q13.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/38245/1/08-2005-CIP29ID42967ch12q13.pdf [ Bibliographic record ]

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 28 15:02:43 CEST 2012

Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

For comments and suggestions or contributions, please contact us
jlhuret@AtlasGeneticsOncology.org.