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SARNP (cytokine induced protein 29 kDa)

Written2005-08Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Other aliasCIP29
HCC-1
LocusID (NCBI) 84324
Atlas_Id 42967
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KMT2A (11q23.3) / SARNP (12q13.2)RBMS2 (12q13.3) / SARNP (12q13.2)RILPL1 (12q24.31) / SARNP (12q13.2)
SARNP (12q13.2) / HDLBP (2q37.3)SARNP (12q13.2) / KMT2A (11q23.3)SARNP (12q13.2) / STMP1 (7q33)
TOMM20 (1q42.3) / SARNP (12q13.2)
Note HCC-1 is an alias for CIP29 (12q13), but also for CCL14 (17q11.2)

Protein

Description 210 amino acids, 29 kDa;contains from N term to C term a SAP domain and 2 nuclear localization domains, and also 3 possible N-glycosylation sites and 9 potential phosphorylation sites. A SAP domain is a putative DNA binding motif involved in chromosomal organization and may regulate transcription, DNA repair, RNA processing.
Expression Widely expressed in fetal and adult tissues, as well as cancer cell lines; upregulated by EPO (erythropoietin), TPO (thrombopoietin), FL (FLT3 Ligand), and SCF (stem cell factor). Associated with cell cycle progression
Localisation Nucleus but some staining was also found in the cytoplasm.

Implicated in

Note
  
Entity M4 acute myeloid leukemia (AML) with t(11;12)(q23;q13) --> KMT2A/SARNP
Note only one case to date
Prognosis unknown
Hybrid/Mutated Gene 5' MLL - 3' CIP29 including the 9 first exons of MLL, and nearly the entire CIP29
Abnormal Protein The fusion protein includes from N term to C term the AT hooks and the methyltransferase domain of MLL and the SAP domain and the C term nuclear localization domains of CIP29.
  

Bibliography

Growth inhibitory effect of Hcc-1/CIP29 is associated with induction of apoptosis, not just with G2/M arrest.
Fukuda S, Pelus LM
Cellular and molecular life sciences : CMLS. 2005 ; 62 (13) : 1526-1527.
PMID 15924260
 
Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29.
Fukuda S, Wu DW, Stark K, Pelus LM
Biochemical and biophysical research communications. 2002 ; 292 (3) : 593-600.
PMID 11922608
 
A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia.
Hashii Y, Kim JY, Sawada A, Tokimasa S, Hiroyuki F, Ohta H, Makiko K, Takihara Y, Ozono K, Hara J
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2004 ; 18 (9) : 1546-1548.
PMID 15284855
 

Citation

This paper should be referenced as such :
Huret, JL ; Senon, S
CIP29 (cytokine induced protein 29 kDa)
Atlas Genet Cytogenet Oncol Haematol. 2005;9(4):305-305.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/CIP29ID42967ch12q13.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;12)(q23;q13) KMT2A/SARNP
t(11;12)(q23;q13) KMT2A/SARNP


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(q13;q24) RILPL1/SARNP


External links

Nomenclature
Cards
AtlasCIP29ID42967ch12q13.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)84324
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:32:04 CEST 2018

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jlhuret@AtlasGeneticsOncology.org.