| Identity |
| Other names | HCC-1 |
| Location | 12q13 |
| Location_base_pair | Starts at and ends at bp from pter |
| Note | HCC-1 is an alias for CIP29 (12q13), but also for CCL14 (17q11.2) |
| Protein |
| Description | 210 amino acids, 29 kDa;contains from N term to C term a SAP domain and 2 nuclear localization domains, and also 3 possible N-glycosylation sites and 9 potential phosphorylation sites. A SAP domain is a putative DNA binding motif involved in chromosomal organization and may regulate transcription, DNA repair, RNA processing. |
| Expression | Widely expressed in fetal and adult tissues, as well as cancer cell lines; upregulated by EPO (erythropoietin), TPO (thrombopoietin), FL (FLT3 Ligand), and SCF (stem cell factor). Associated with cell cycle progression |
| Localisation | Nucleus but some staining was also found in the cytoplasm. |
| Implicated in |
| Entity | M4 acute non lymphocytic leukaemia (ANLL) with t(11;12)(q23;q13) --> (MLL/CIP29) |
| Note | only one case to date |
| Prognosis | unknown |
| Hybrid/Mutated Gene | 5' MLL - 3' CIP29 including the 9 first exons of MLL, and nearly the entire CIP29 |
| Abnormal Protein | The fusion protein includes from N term to C term the AT hooks and the methyltransferase domain of MLL and the SAP domain and the C term nuclear localization domains of CIP29. |
| External links |
| Nomenclature | |
|---|---|
| Cards | |
| SOURCE (Stanford) | |
| Genomic and cartography | |
| OMIM | |
| Gene and transcription | |
| Reference sequence (RefSeq transcript) :SRS | |
| Reference transcript : Entrez | |
| RefSeq genomic : SRS | |
| RefSeq genomic : Entrez | |
| Protein : pattern, domain, 3D structure | |
| Domain families : Pfam SRS | |
| Domain families : Pfam Sanger | |
| Domain families : Pfam NCBI | |
| Crystal structure of protein : PDB SRS | |
| Crystal structure of protein : PDBSum | |
| Crystal structure of protein : IMB | |
| Crystal structure of protein : PDB RSDB | |
| Protein Interaction databases | |
| Polymorphism : SNP, mutations, diseases | |
| Hereditary diseases : OMIM | |
| Hereditary diseases : GENETests | |
| General knowledge | |
| Keywords Ontology : AmiGO | |
| Keywords Ontology : EGO-EBI | |
| Pathways : BIOCARTA | |
| Pathways : KEGG | |
| Other databases | |
| Probes | |
| Literature |
| Bibliography |
| Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29. |
| Fukuda S, Wu DW, Stark K, Pelus LM |
| Biochemical and biophysical research communications. 2002 ; 292 (3) : 593-600. |
| PMID 11922608 |
| A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia. |
| Hashii Y, Kim JY, Sawada A, Tokimasa S, Hiroyuki F, Ohta H, Makiko K, Takihara Y, Ozono K, Hara J |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2004 ; 18 (9) : 1546-1548. |
| PMID 15284855 |
| Growth inhibitory effect of Hcc-1/CIP29 is associated with induction of apoptosis, not just with G2/M arrest. |
| Fukuda S, Pelus LM |
| Cellular and molecular life sciences : CMLS. 2005 ; 62 (13) : 1526-1527. |
| PMID 15924260 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 08-2005 | Jean Loup Huret, Sylvie Senon |
| Citation |
| This paper should be referenced as such : |
| Huret JL, Senon S . CIP29 (cytokine induced protein 29 kDa). Atlas Genet Cytogenet Oncol Haematol. August 2005 . URL : http://AtlasGeneticsOncology.org/Genes/CIP29ID42967ch12q13.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Aug 31 20:06:52 CEST 2010 |
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