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CIP29 (cytokine induced protein 29 kDa)

Identity

Other namesHCC-1
HGNC (Hugo)
Location 12q13
Location_base_pair Starts at 54437325 and ends at 54497807 bp from pter ( according to hg18-Mar_2006)  [Mapping]
Note HCC-1 is an alias for CIP29 (12q13), but also for CCL14 (17q11.2)

Protein

Description 210 amino acids, 29 kDa;contains from N term to C term a SAP domain and 2 nuclear localization domains, and also 3 possible N-glycosylation sites and 9 potential phosphorylation sites. A SAP domain is a putative DNA binding motif involved in chromosomal organization and may regulate transcription, DNA repair, RNA processing.
Expression Widely expressed in fetal and adult tissues, as well as cancer cell lines; upregulated by EPO (erythropoietin), TPO (thrombopoietin), FL (FLT3 Ligand), and SCF (stem cell factor). Associated with cell cycle progression
Localisation Nucleus but some staining was also found in the cytoplasm.

Implicated in

Entity M4 acute non lymphocytic leukaemia (ANLL) with t(11;12)(q23;q13) --> (MLL/CIP29)
Note only one case to date
Prognosis unknown
Hybrid/Mutated Gene 5' MLL - 3' CIP29 including the 9 first exons of MLL, and nearly the entire CIP29
Abnormal Protein The fusion protein includes from N term to C term the AT hooks and the methyltransferase domain of MLL and the SAP domain and the C term nuclear localization domains of CIP29.
  

External links

Nomenclature
HGNC (Hugo)-   -
Entrez_Gene (NCBI)CIP29  84324  cytokine induced protein 29 kDa
Cards
AtlasCIP29ID42967ch12q13
GeneCards (Weizmann)CIP29
Ensembl (Hinxton)ENSG00000205323 [Gene_View]  CIP29 [Vega]
AceView (NCBI)CIP29
Genatlas (Paris)CIP29
euGene (Indiana)84324
SOURCE (Stanford)NM_033082
Genomic and cartography
GoldenPath (UCSC)CIP29  -  12q13   chr12:54437325-54497807 -  12q13.2   [Description]    (hg18-Mar_2006)
EnsemblCIP29 - 12q13.2 [CytoView]
Mapping of homologs : NCBICIP29 [Mapview]
OMIM610049   
Gene and transcription
Gene : Genbank (Entrez)AF161434 AF486281 AK222719 AK290508 BC007099
Reference sequence (RefSeq transcript) :SRSNM_033082
Reference transcript : EntrezNM_033082
RefSeq genomic : SRSAC_000055 AC_000144 NC_000012 NT_029419 NW_001838059 NW_925395
RefSeq genomic : EntrezAC_000055 AC_000144 NC_000012 NT_029419 NW_001838059 NW_925395
Consensus coding sequences : CCDS NCBICIP29
Cluster EST : UnigeneHs.505676 [ SRS ] Hs.505676 [ NCBI ]
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP82979 (SRS) P82979 (Expasy) P82979 (Uniprot)
With graphics : InterProP82979
Splice isoforms : VarSplice FASTAP82979(VarSplice FASTA)
Domaine pattern : Prosite (SRS)SAP (PS50800)   
Domain pattern : Prosite (Expaxy)SAP (PS50800)   
Domains : Interpro (SRS)SAP_DNA_bd   
Domains : Interpro (EBI)SAP_DNA_bd   
Related proteins : CluSTrP82979
Domain families : Pfam SRSSAP (PF02037)   
Domain families : Pfam SangerSAP (PF02037)   
Domain families : Pfam NCBIpfam02037   
Domain families : Smart EMBLSAP (SM00513)
Blocks (Seattle)P82979
Crystal structure of protein : PDB SRS2DO1   
Crystal structure of protein : PDBSum2DO1   
Crystal structure of protein : IMB2DO1   
Crystal structure of protein : PDB RSDB2DO1   
HPRD16716
Protein Interaction databases
DIP (DOE-UCLA)P82979
IntAct (EBI)P82979
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBICIP29
SNP : GeneSNP UtahCIP29
SNP : HGBaseCIP29
Genetic variants : HAPMAPCIP29
Mutations and Diseases : HGMD-
Hereditary diseases : OMIM610049   
Hereditary diseases : GENETests610049   
Diseases : Genetic Association-
General knowledge
Homologs : HomoloGeneCIP29
Homology/Alignments : Family Browser UCSCCIP29
Phylogenetic Trees/Animal Genes : TreeFam-
Chemical/Protein Interactions : CTD84324
Keywords Ontology : AmiGODNA binding  protein binding  nucleus  transcription  regulation of transcription, DNA-dependent  regulation of translation  
Keywords Ontology : EGO-EBIDNA binding  protein binding  nucleus  transcription  regulation of transcription, DNA-dependent  regulation of translation  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Literature
PubMed16 Pubmed reference(s) in Entrez
PubGeneCIP29

Bibliography

Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29.
Fukuda S, Wu DW, Stark K, Pelus LM
Biochemical and biophysical research communications. 2002 ; 292 (3) : 593-600.
PMID 11922608
 
A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia.
Hashii Y, Kim JY, Sawada A, Tokimasa S, Hiroyuki F, Ohta H, Makiko K, Takihara Y, Ozono K, Hara J
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2004 ; 18 (9) : 1546-1548.
PMID 15284855
 
Growth inhibitory effect of Hcc-1/CIP29 is associated with induction of apoptosis, not just with G2/M arrest.
Fukuda S, Pelus LM
Cellular and molecular life sciences : CMLS. 2005 ; 62 (13) : 1526-1527.
PMID 15924260
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written08-2005Jean Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :
Huret JL, Senon S . CIP29 (cytokine induced protein 29 kDa). Atlas Genet Cytogenet Oncol Haematol. August 2005 .
URL : http://AtlasGeneticsOncology.org/Genes/CIP29ID42967ch12q13.html

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indexed on : Sat Jun 27 16:38:37 CEST 2009
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