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DEK (DEK proto-oncogene)

Written1998-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Alias_namesDEK oncogene (DNA binding)
DEK oncogene
Alias_symbol (synonym)D6S231E
Other alias
LocusID (NCBI) 7913
Atlas_Id 23
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 18224169 and ends at 18264568 bp from pter ( according to hg19-Feb_2009)  [Mapping DEK.png]
  DEK (6p23) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
  DEK (DEK proto-oncogene) Hybridization with DEK / NUP214 t(6;9) probe (Kreatech, Leica Biosystems Inc., US) showing DEK gene on 6p22.3 (green signals - Courtesy Adriana Zamecnikova.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CABIN1 (22q11.23) / DEK (6p22.3)DEK (6p22.3) / CABIN1 (22q11.23)DEK (6p22.3) / CD164 (6q21)
DEK (6p22.3) / DEK (6p22.3)DEK (6p22.3) / EIF5B (2q11.2)DEK (6p22.3) / NUP214 (9q34.13)
EYS (6q12) / DEK (6p22.3)GRN (17q21.31) / DEK (6p22.3)LUC7L3 (17q21.33) / DEK (6p22.3)
NUP214 (9q34.13) / DEK (6p22.3)STAU2 (8q21.11) / DEK (6p22.3)


Description spans on a 40 kb genomic segment
Transcription 2.7 kb mRNA; coding sequence: 1.1 kb


Description 375 amino acids; 43 kDa; contains numerous acidic domains (Asp/Glu rich) and a nuclear localisation signal
Expression wide
Localisation potentially nuclear
Function site specific DNA binding protein involved in transcriptional regulation and signal transduction

Implicated in

Entity t(6;9)(p23;q34)/AML or MDS --> DEK-CAN
Disease M2, M4 AML or MDS
Prognosis remission difficult to obtain
Cytogenetics this chromosome anomaly may be over loocked
Hybrid/Mutated Gene 5' DEK - 3' CAN; chromosome 6 breakpoint clusters in a single intron
Abnormal Protein head to tail DEK/CAN fusion protein (the alternative SET/CAN is exceptional); almost the entire DEK protein fused to the C-terminal two-thirds of the CAN protein; nuclear localization


Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN.
Fornerod M, Boer J, van Baal S, Morreau H, Grosveld G
Oncogene. 1996 ; 13 (8) : 1801-1808.
PMID 8895527
DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer.
Fu GK, Grosveld G, Markovitz DM
Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (5) : 1811-1815.
PMID 9050861
The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.
von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G
Molecular and cellular biology. 1992 ; 12 (4) : 1687-1697.
PMID 1549122


This paper should be referenced as such :
Jean-Loup Huret
DEK (DEK oncogene)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):5-5.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;9)(p22;q34) DEK/NUP214
t(6;9)(p22;q34) DEK/NUP214 in Childhood

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(6;6)(p22;q12) EYS/DEK

External links

HGNC (Hugo)DEK   2768
Entrez_Gene (NCBI)DEK  7913  DEK proto-oncogene
GeneCards (Weizmann)DEK
Ensembl hg19 (Hinxton)ENSG00000124795 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124795 [Gene_View]  ENSG00000124795 [Sequence]  chr6:18224169-18264568 [Contig_View]  DEK [Vega]
ICGC DataPortalENSG00000124795
TCGA cBioPortalDEK
Genatlas (Paris)DEK
SOURCE (Princeton)DEK
Genetics Home Reference (NIH)DEK
Genomic and cartography
GoldenPath hg38 (UCSC)DEK  -     chr6:18224169-18264568 -  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DEK  -     6p22.3   [Description]    (hg19-Feb_2009)
GoldenPathDEK - 6p22.3 [CytoView hg19]  DEK - 6p22.3 [CytoView hg38]
Mapping of homologs : NCBIDEK [Mapview hg19]  DEK [Mapview hg38]
Gene and transcription
Genbank (Entrez)AJ270688 AJ420539 AK294079 AK297749 AK298089
RefSeq transcript (Entrez)NM_001134709 NM_003472
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DEK
Cluster EST : UnigeneHs.484813 [ NCBI ]
CGAP (NCI)Hs.484813
Alternative Splicing GalleryENSG00000124795
Gene ExpressionDEK [ NCBI-GEO ]   DEK [ EBI - ARRAY_EXPRESS ]   DEK [ SEEK ]   DEK [ MEM ]
Gene Expression Viewer (FireBrowse)DEK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7913
GTEX Portal (Tissue expression)DEK
Human Protein AtlasENSG00000124795-DEK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35659   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35659  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35659
Splice isoforms : SwissVarP35659
Domains : Interpro (EBI)DEK_C    SAP_dom    SAP_dom_sf   
Domain families : Pfam (Sanger)DEK_C (PF08766)   
Domain families : Pfam (NCBI)pfam08766   
Domain families : Smart (EMBL)SAP (SM00513)  
Conserved Domain (NCBI)DEK
DMDM Disease mutations7913
Blocks (Seattle)DEK
PDB (RSDB)1Q1V    2JX3   
PDB Europe1Q1V    2JX3   
PDB (PDBSum)1Q1V    2JX3   
PDB (IMB)1Q1V    2JX3   
Structural Biology KnowledgeBase1Q1V    2JX3   
SCOP (Structural Classification of Proteins)1Q1V    2JX3   
CATH (Classification of proteins structures)1Q1V    2JX3   
Human Protein Atlas [tissue]ENSG00000124795-DEK [tissue]
Peptide AtlasP35659
IPIIPI00020021   IPI00425937   IPI00942944   IPI00909779   IPI00967473   IPI00968273   IPI00966422   
Protein Interaction databases
IntAct (EBI)P35659
Ontologies - Pathways
Ontology : AmiGODNA binding  RNA binding  nucleus  nucleus  nucleoplasm  chromatin organization  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  signal transduction  viral genome replication  histone binding  histone binding  positive regulation of gene expression, epigenetic  regulation of double-strand break repair  regulation of double-strand break repair  
Ontology : EGO-EBIDNA binding  RNA binding  nucleus  nucleus  nucleoplasm  chromatin organization  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  signal transduction  viral genome replication  histone binding  histone binding  positive regulation of gene expression, epigenetic  regulation of double-strand break repair  regulation of double-strand break repair  
REACTOMEP35659 [protein]
REACTOME PathwaysR-HSA-8864260 [pathway]   
NDEx NetworkDEK
Atlas of Cancer Signalling NetworkDEK
Wikipedia pathwaysDEK
Orthology - Evolution
GeneTree (enSembl)ENSG00000124795
Phylogenetic Trees/Animal Genes : TreeFamDEK
Homologs : HomoloGeneDEK
Homology/Alignments : Family Browser (UCSC)DEK
Gene fusions - Rearrangements
Fusion : MitelmanDEK/NUP214 [6p22.3/9q34.13]  
Fusion : MitelmanEYS/DEK [6q12/6p22.3]  [t(6;6)(p22;q12)]  
Fusion : TICdbNUP214 [9q34.13]  -  DEK [6p22.3]
Fusion : FusionGDB15480    36420    9700    9701    9702    9703   
Fusion : Fusion_HubABCC5--DEK    ABL1--DEK    ADI1--DEK    C1QBP--DEK    C9ORF142--DEK    CABIN1--DEK    CAN--DEK    CDKAL1--DEK    CRBN--DEK    DEK--ASCC2    DEK--ATP5C1    DEK--CABIN1    DEK--CAN    DEK--CD164    DEK--CDK14   
DEK--CDKAL1    DEK--CLEC2B    DEK--CMIP    DEK--COL21A1    DEK--COX6C    DEK--DEK    DEK--DPYSL3    DEK--EEF2    DEK--EIF5B    DEK--GPR116    DEK--KIF25    DEK--MLIP    DEK--NDUFS1    DEK--NSD1    DEK--NUP210L   
DEK--NUP214    DEK--PRRC2B    DEK--RFWD2    DEK--RNF217    DEK--RPS20    DEK--SET    DEK--SRPK1    EEF2--DEK    EIF4B--DEK    ERC1--DEK    GRN--DEK    KDM1B--DEK    KIF13A--DEK    LUC7L3--DEK    NUP214--DEK   
RCAN2--DEK    RNF144B--DEK    STAU2--DEK   
Fusion : QuiverDEK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDEK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DEK
Exome Variant ServerDEK
ExAC (Exome Aggregation Consortium)ENSG00000124795
GNOMAD BrowserENSG00000124795
Varsome BrowserDEK
Genetic variants : HAPMAP7913
Genomic Variants (DGV)DEK [DGVbeta]
DECIPHERDEK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDEK 
ICGC Data PortalDEK 
TCGA Data PortalDEK 
Broad Tumor PortalDEK
OASIS PortalDEK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDEK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDEK
Mutations and Diseases : HGMDDEK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DEK
DgiDB (Drug Gene Interaction Database)DEK
DoCM (Curated mutations)DEK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DEK (select a term)
NCG5 (London)DEK
Cancer3DDEK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry DEK
NextProtP35659 [Medical]
Target ValidationDEK
Huge Navigator DEK [HugePedia]
snp3D : Map Gene to Disease7913
BioCentury BCIQDEK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7913
Chemical/Pharm GKB GenePA27251
Clinical trialDEK
canSAR (ICR)DEK (select the gene name)
DataMed IndexDEK
PubMed158 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 21:14:25 CET 2019

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