DEK (DEK proto-oncogene)

1998-01-01 Jean-Loup Huret Affiliation

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC

DEK

LOCATION

6p22.3

IMAGE

LEGEND

DEK (6p23) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.

IMAGE

LEGEND

DEK (DEK proto-oncogene) Hybridization with DEK / NUP214 t(6;9) probe (Kreatech, Leica Biosystems Inc., US) showing DEK gene on 6p22.3 (green signals - Courtesy Adriana Zamecnikova.

LOCUSID

7913

ALIAS

D6S231E

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

spans on a 40 kb genomic segment

Transcription

2.7 kb mRNA; coding sequence: 1.1 kb

Proteins

Description

375 amino acids; 43 kDa; contains numerous acidic domains (Asp/Glu rich) and a nuclear localisation signal

Expression

wide

Localisation

potentially nuclear

Function

site specific DNA binding protein involved in transcriptional regulation and signal transduction

Implicated in

Entity name

t(6;9)(p23;q34)/AML or MDS --> DEK-CAN

Disease

M2, M4 AML or MDS

Prognosis

remission difficult to obtain

Cytogenetics

this chromosome anomaly may be over loocked

Hybrid gene

5 DEK - 3 CAN; chromosome 6 breakpoint clusters in a single intron

Fusion protein

head to tail DEK/CAN fusion protein (the alternative SET/CAN is exceptional); almost the entire DEK protein fused to the C-terminal two-thirds of the CAN protein; nuclear localization

Other Information

Locus ID:

NCBI: 7913
MIM: 125264
HGNC: 2768
Ensembl: ENSG00000124795

Variants:

dbSNP: 7913
ClinVar: 7913
TCGA: ENSG00000124795
COSMIC: DEK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000124795	ENST00000244776	P35659
ENSG00000124795	ENST00000503715	D6RDA2
ENSG00000124795	ENST00000505224	B4DFG0
ENSG00000124795	ENST00000507591	H0Y993
ENSG00000124795	ENST00000515742	D6R9L5
ENSG00000124795	ENST00000515770	H0Y8X0
ENSG00000124795	ENST00000651624	A0A494C198
ENSG00000124795	ENST00000651992	A0A494C028
ENSG00000124795	ENST00000652576	P35659
ENSG00000124795	ENST00000652689	P35659

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
B-WICH complex positively regulates rRNA expression	REACTOME	R-HSA-5250924
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	REACTOME	R-HSA-8864260

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12388720	2002	Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes.	122
12140263	2002	Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.	113
16809543	2006	Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.	74
19679545	2009	Melanoma proliferation and chemoresistance controlled by the DEK oncogene.	60
20040570	2010	A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor.	60
16254365	2005	The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7.	59
16894028	2006	Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions.	57
16721057	2006	DEK Expression is controlled by E2F and deregulated in diverse tumor types.	53
18332104	2008	DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress.	49
19223548	2009	Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.	49

Citation

Jean-Loup Huret

DEK (DEK proto-oncogene)

Atlas Genet Cytogenet Oncol Haematol. 1998-01-01

Online version: http://atlasgeneticsoncology.org/gene/23/dek