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ELAC2 (elaC homolog 2 (E. coli))

Written2008-02Yang Chen, Sean Tavtigian, Donna Shattuck
Myriad Genetics, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USA

(Note : for Links provided by Atlas : click)


Other aliasHPC2
TRZ1 (tRNaseZL)
LocusID (NCBI) 60528
Atlas_Id 40437
Location 17p12  [Link to chromosome band 17p12]
Location_base_pair Starts at and ends at bp from pter
Local_order Telomeric to HS3ST3A1 and centromeric to KIAA0672.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DLST (14q24.3) / ELAC2 (17p12)ELAC2 (17p12) / COX10 (17p12)RPSAP52 (12q14.3) / ELAC2 (17p12)
Note There is a human paralog of this gene on chromosome 18 called ELAC1 that is homologous to the C-terminal half of ELAC2.


Note Ubiquitously expressed in a variety of tissues, tumors and developmental stages.
Description The genomic size of ELAC2 gene is about 25.6 kb representing a mRNA of 2966 bp with 26 exons.
Transcription There is no evidence of alternative splicing of the transcript.
Pseudogene No known pseudogenes.


Description ELAC2 gene encodes a protein of 826 amino acids. Orthologs are found in Eukaryotes including M. musculus, R. norvegicus, C. elegans, D. melanogaster, S. cerevisiae, S. pombe and A. thaliana.
Expression Not determined.
Localisation Not determined. But is implicated in nucleus upon overexpression in cell lines. Yeast ortholog (TRZ1p) is detected in cytosol, nucleus and mitochondria via large-scale analysis with GFP tagged gene product.
Function ELAC2 has tRNA processing activity as detected by in vitro biochemistry assays. The N-terminus of ELAC2 is required for the Rnase 65 activity. The C-terminus (481-826 aa) of ELAC2, which is homologous to ELAC1, possesses tRNA 3' processing endoribonuclease acitivity (tRNaseZ). Overexpressed ELAC2 binds gamma-tubulin complex and is involved in cell cycle regulation. ELAC2 has also been shown to potentiate TGF-beta-induced growth arrest of prostate cells via over-expression upon transfection and down-regulation via siRNA.


Germinal One pedigree-specific insertion/frameshift, 1641insG, resulting in frameshift after L547, and leading to termination after the miscoding of 67 residues. Four missense variants, S217L, A541T, E622V and R781H.
Somatic Not determined.

Implicated in

Entity Prostate Cancer
Note TGF-beta signaling mediated growth arrest via physical interactions with Smad2 / Smad3 and FAST-1, and potentiation of Smad2-driven (ARE)2-Luciferease reporter activity. Also implicated in RNA processing.
Disease Hereditary prostate cancer and sporadic prostate cancer.


Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z.
Chen Y, Beck A, Davenport C, Chen Y, Shattuck D, Tavtigian SV
BMC molecular biology. 2005 ; 6 (1) : page 12.
PMID 15892892
Association of common missense changes in ELAC2 ( HPC2) with prostate cancer in a Japanese case-control series.
Fujiwara H, Emi M, Nagai H, Nishimura T, Konishi N, Kubota Y, Ichikawa T, Takahashi S, Shuin T, Habuchi T, Ogawa O, Inoue K, Skolnick MH, Swensen J, Camp NJ, Tavtigian SV
Journal of human genetics. 2002 ; 47 (12) : 641-648.
PMID 12522685
Assigning function to yeast proteins by integration of technologies.
Hazbun TR, Malmström L, Anderson S, Graczyk BJ, Fox B, Riffle M, Sundin BA, Aranda JD, McDonald WH, Chiu CH, Snydsman BE, Bradley P, Muller EG, Fields S, Baker D, Yates JR 3rd, Davis TN
Molecular cell. 2003 ; 12 (6) : 1353-1365.
PMID 14690591
Global analysis of protein localization in budding yeast.
Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK
Nature. 2003 ; 425 (6959) : 686-691.
PMID 14562095
The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the gamma-tubulin complex.
Korver W, Guevara C, Chen Y, Neuteboom S, Bookstein R, Tavtigian S, Lees E
International journal of cancer. Journal international du cancer. 2003 ; 104 (3) : 283-288.
PMID 12569551
ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells.
Noda D, Itoh S, Watanabe Y, Inamitsu M, Dennler S, Itoh F, Koike S, Danielpour D, ten Dijke P, Kato M
Oncogene. 2006 ; 25 (41) : 5591-5600.
PMID 16636667
ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer.
Rökman A, Ikonen T, Mononen N, Autio V, Matikainen MP, Koivisto PA, Tammela TL, Kallioniemi OP, Schleutker J
Cancer research. 2001 ; 61 (16) : 6038-6041.
PMID 11507049
Polymorphisms in the prostate cancer susceptibility gene HPC2/ELAC2 in multiplex families and healthy controls.
Suarez BK, Gerhard DS, Lin J, Haberer B, Nguyen L, Kesterson NK, Catalona WJ
Cancer research. 2001 ; 61 (13) : 4982-4984.
PMID 11431329
The N-terminal half-domain of the long form of tRNase Z is required for the RNase 65 activity.
Takaku H, Minagawa A, Takagi M, Nashimoto M
Nucleic acids research. 2004 ; 32 (15) : 4429-4438.
PMID 15317868
A candidate prostate cancer susceptibility gene at chromosome 17p.
Tavtigian SV, Simard J, Teng DH, Abtin V, Baumgard M, Beck A, Camp NJ, Carillo AR, Chen Y, Dayananth P, Desrochers M, Dumont M, Farnham JM, Frank D, Frye C, Ghaffari S, Gupte JS, Hu R, Iliev D, Janecki T, Kort EN, Laity KE, Leavitt A, Leblanc G, McArthur-Morrison J, Pederson A, Penn B, Peterson KT, Reid JE, Richards S, Schroeder M, Smith R, Snyder SC, Swedlund B, Swensen J, Thomas A, Tranchant M, Woodland AM, Labrie F, Skolnick MH, Neuhausen S, Rommens J, Cannon-Albright LA
Nature genetics. 2001 ; 27 (2) : 172-180.
PMID 11175785
Role of HPC2/ELAC2 in hereditary prostate cancer.
Wang L, McDonnell SK, Elkins DA, Slager SL, Christensen E, Marks AF, Cunningham JM, Peterson BJ, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN
Cancer research. 2001 ; 61 (17) : 6494-6499.
PMID 11522646


This paper should be referenced as such :
Chen, Y ; Tavtigian, S ; Shattuck, D. ELAC2 (elaC homolog 2 (E
Atlas Genet Cytogenet Oncol Haematol. 2008;12(6):430-431.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary prostate cancer

External links

Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)60528
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
canSAR (ICR) (select the gene name)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 18 17:34:58 CEST 2018

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