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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
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ELAC2 (elaC homolog 2 (E. coli))


Other namesHPC2
TRZ1 (tRNaseZL)
LocusID (NCBI) 60528
Location 17p12
Location_base_pair Starts at 12894929 and ends at 12921381 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order Telomeric to HS3ST3A1 and centromeric to KIAA0672.
Note There is a human paralog of this gene on chromosome 18 called ELAC1 that is homologous to the C-terminal half of ELAC2.


Note Ubiquitously expressed in a variety of tissues, tumors and developmental stages.
Description The genomic size of ELAC2 gene is about 25.6 kb representing a mRNA of 2966 bp with 26 exons.
Transcription There is no evidence of alternative splicing of the transcript.
Pseudogene No known pseudogenes.


Description ELAC2 gene encodes a protein of 826 amino acids. Orthologs are found in Eukaryotes including M. musculus, R. norvegicus, C. elegans, D. melanogaster, S. cerevisiae, S. pombe and A. thaliana.
Expression Not determined.
Localisation Not determined. But is implicated in nucleus upon overexpression in cell lines. Yeast ortholog (TRZ1p) is detected in cytosol, nucleus and mitochondria via large-scale analysis with GFP tagged gene product.
Function ELAC2 has tRNA processing activity as detected by in vitro biochemistry assays. The N-terminus of ELAC2 is required for the Rnase 65 activity. The C-terminus (481-826 aa) of ELAC2, which is homologous to ELAC1, possesses tRNA 3' processing endoribonuclease acitivity (tRNaseZ). Overexpressed ELAC2 binds gamma-tubulin complex and is involved in cell cycle regulation. ELAC2 has also been shown to potentiate TGF-beta-induced growth arrest of prostate cells via over-expression upon transfection and down-regulation via siRNA.


Germinal One pedigree-specific insertion/frameshift, 1641insG, resulting in frameshift after L547, and leading to termination after the miscoding of 67 residues. Four missense variants, S217L, A541T, E622V and R781H.
Somatic Not determined.

Implicated in

Entity Prostate Cancer
Note TGF-beta signaling mediated growth arrest via physical interactions with Smad2 / Smad3 and FAST-1, and potentiation of Smad2-driven (ARE)2-Luciferease reporter activity. Also implicated in RNA processing.
Disease Hereditary prostate cancer and sporadic prostate cancer.

External links

HGNC (Hugo)ELAC2   14198
Entrez_Gene (NCBI)ELAC2  60528  elaC ribonuclease Z 2
GeneCards (Weizmann)ELAC2
Ensembl hg19 (Hinxton) [Gene_View]  chr17:12894929-12921381 [Contig_View]  ELAC2 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr17:12894929-12921381 [Contig_View]  ELAC2 [Vega]
Genatlas (Paris)ELAC2
SOURCE (Princeton)ELAC2
Genomic and cartography
GoldenPath hg19 (UCSC)ELAC2  -     chr17:12894929-12921381 -  17p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ELAC2  -     17p11.2   [Description]    (hg38-Dec_2013)
EnsemblELAC2 - 17p11.2 [CytoView hg19]  ELAC2 - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIELAC2 [Mapview hg19]  ELAC2 [Mapview hg38]
OMIM605367   614731   615440   
Gene and transcription
Genbank (Entrez)AA706335 AF304370 AK001392 AK074244 AK094012
RefSeq transcript (Entrez)NM_001165962 NM_018127 NM_173717
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_015808 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)ELAC2
Cluster EST : UnigeneHs.434232 [ NCBI ]
CGAP (NCI)Hs.434232
Alternative Splicing : Fast-db (Paris)GSHG0013114
Gene ExpressionELAC2 [ NCBI-GEO ]     ELAC2 [ SEEK ]   ELAC2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQ52 (Uniprot)
NextProtQ9BQ52  [Medical]
With graphics : InterProQ9BQ52
Splice isoforms : SwissVarQ9BQ52 (Swissvar)
Catalytic activity : Enzyme3.1.26.11 [ Enzyme-Expasy ] [ IntEnz-EBI ] [ BRENDA ] [ KEGG ]   
Domains : Interpro (EBI)Beta-lactamas-like    tRNase_Z_dom   
Related proteins : CluSTrQ9BQ52
Domain families : Pfam (Sanger)Lactamase_B_4 (PF13691)   
Domain families : Pfam (NCBI)pfam13691   
Domain families : Smart (EMBL)Lactamase_B (SM00849)  
DMDM Disease mutations60528
Blocks (Seattle)Q9BQ52
Peptide AtlasQ9BQ52
IPIIPI00396627   IPI00398822   IPI00398823   IPI00798145   IPI01011409   IPI00789842   
Protein Interaction databases
IntAct (EBI)Q9BQ52
Ontologies - Pathways
Ontology : AmiGOendonuclease activity  nucleus  nucleoplasm  mitochondrion  poly(A) RNA binding  metal ion binding  mitochondrial tRNA 3'-trailer cleavage, endonucleolytic  
Ontology : EGO-EBIendonuclease activity  nucleus  nucleoplasm  mitochondrion  poly(A) RNA binding  metal ion binding  mitochondrial tRNA 3'-trailer cleavage, endonucleolytic  
Pathways : KEGGRNA transport   
Protein Interaction DatabaseELAC2
DoCM (Curated mutations)ELAC2
Wikipedia pathwaysELAC2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerELAC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELAC2
Exome Variant ServerELAC2
Genetic variants : HAPMAPELAC2
Genomic Variants (DGV)ELAC2 [DGVbeta]
Somatic Mutations in Cancer : COSMICELAC2 
CONAN: Copy Number AnalysisELAC2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
DECIPHER (Syndromes)17:12894929-12921381
Mutations and Diseases : HGMDELAC2
OMIM605367    614731    615440   
NextProtQ9BQ52 [Medical]
Disease Genetic AssociationELAC2
Huge Navigator ELAC2 [HugePedia]  ELAC2 [HugeCancerGEM]
snp3D : Map Gene to Disease60528
DGIdb (Drug Gene Interaction db)ELAC2
General knowledge
Homologs : HomoloGeneELAC2
Homology/Alignments : Family Browser (UCSC)ELAC2
Phylogenetic Trees/Animal Genes : TreeFamELAC2
Chemical/Protein Interactions : CTD60528
Chemical/Pharm GKB GenePA27739
Clinical trialELAC2
Other databases
PubMed63 Pubmed reference(s) in Entrez


ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer.
Rˆkman A, Ikonen T, Mononen N, Autio V, Matikainen MP, Koivisto PA, Tammela TL, Kallioniemi OP, Schleutker J
Cancer research. 2001 ; 61 (16) : 6038-6041.
PMID 11507049
Polymorphisms in the prostate cancer susceptibility gene HPC2/ELAC2 in multiplex families and healthy controls.
Suarez BK, Gerhard DS, Lin J, Haberer B, Nguyen L, Kesterson NK, Catalona WJ
Cancer research. 2001 ; 61 (13) : 4982-4984.
PMID 11431329
A candidate prostate cancer susceptibility gene at chromosome 17p.
Tavtigian SV, Simard J, Teng DH, Abtin V, Baumgard M, Beck A, Camp NJ, Carillo AR, Chen Y, Dayananth P, Desrochers M, Dumont M, Farnham JM, Frank D, Frye C, Ghaffari S, Gupte JS, Hu R, Iliev D, Janecki T, Kort EN, Laity KE, Leavitt A, Leblanc G, McArthur-Morrison J, Pederson A, Penn B, Peterson KT, Reid JE, Richards S, Schroeder M, Smith R, Snyder SC, Swedlund B, Swensen J, Thomas A, Tranchant M, Woodland AM, Labrie F, Skolnick MH, Neuhausen S, Rommens J, Cannon-Albright LA
Nature genetics. 2001 ; 27 (2) : 172-180.
PMID 11175785
Role of HPC2/ELAC2 in hereditary prostate cancer.
Wang L, McDonnell SK, Elkins DA, Slager SL, Christensen E, Marks AF, Cunningham JM, Peterson BJ, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN
Cancer research. 2001 ; 61 (17) : 6494-6499.
PMID 11522646
Association of common missense changes in ELAC2 ( HPC2) with prostate cancer in a Japanese case-control series.
Fujiwara H, Emi M, Nagai H, Nishimura T, Konishi N, Kubota Y, Ichikawa T, Takahashi S, Shuin T, Habuchi T, Ogawa O, Inoue K, Skolnick MH, Swensen J, Camp NJ, Tavtigian SV
Journal of human genetics. 2002 ; 47 (12) : 641-648.
PMID 12522685
Assigning function to yeast proteins by integration of technologies.
Hazbun TR, Malmstrˆm L, Anderson S, Graczyk BJ, Fox B, Riffle M, Sundin BA, Aranda JD, McDonald WH, Chiu CH, Snydsman BE, Bradley P, Muller EG, Fields S, Baker D, Yates JR 3rd, Davis TN
Molecular cell. 2003 ; 12 (6) : 1353-1365.
PMID 14690591
Global analysis of protein localization in budding yeast.
Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK
Nature. 2003 ; 425 (6959) : 686-691.
PMID 14562095
The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the gamma-tubulin complex.
Korver W, Guevara C, Chen Y, Neuteboom S, Bookstein R, Tavtigian S, Lees E
International journal of cancer. Journal international du cancer. 2003 ; 104 (3) : 283-288.
PMID 12569551
A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.
Takaku H, Minagawa A, Takagi M, Nashimoto M
Nucleic acids research. 2003 ; 31 (9) : 2272-2278.
PMID 12711671
The N-terminal half-domain of the long form of tRNase Z is required for the RNase 65 activity.
Takaku H, Minagawa A, Takagi M, Nashimoto M
Nucleic acids research. 2004 ; 32 (15) : 4429-4438.
PMID 15317868
Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z.
Chen Y, Beck A, Davenport C, Chen Y, Shattuck D, Tavtigian SV
BMC molecular biology. 2005 ; 6 (1) : page 12.
PMID 15892892
ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells.
Noda D, Itoh S, Watanabe Y, Inamitsu M, Dennler S, Itoh F, Koike S, Danielpour D, ten Dijke P, Kato M
Oncogene. 2006 ; 25 (41) : 5591-5600.
PMID 16636667
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Written02-2008Yang Chen, Sean Tavtigian, Donna Shattuck
Myriad Genetics, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USA


This paper should be referenced as such :
Chen, Y ; Tavtigian, S ; Shattuck, D. ELAC2 (elaC homolog 2 (E
Atlas Genet Cytogenet Oncol Haematol. 2008;12(6):430-431.
Free journal version : [ pdf ]   [ DOI ]

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indexed on : Sat Mar 28 12:40:17 CET 2015

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