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MAPK8 (mitogen-activated protein kinase 8)

Written2003-01Fei Chen
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)JNK1 (C-Jun N-terminal kinase 1)
Stress-activated protein kinase 1 (SAPK1)
HGNC (Hugo) MAPK8
HGNC Alias symbJNK
JNK1
SAPK1
HGNC Alias nameJUN N-terminal kinase
HGNC Previous namePRKM8
LocusID (NCBI) 5599
Atlas_Id 196
Location 10q11.22  [Link to chromosome band 10q11]
Location_base_pair Starts at 48306677 and ends at 48439359 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping MAPK8.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMN1 (12p11.21)::MAPK8 (10q11.22)COG6 (13q14.11)::MAPK8 (10q11.22)MAPK8 (10q11.22)::C10orf53 (10q11.23)
MAPK8 (10q11.22)::EEF1AKMT3 (12q14.1)MAPK8 (10q11.22)::KIRREL2 (19q13.12)

DNA/RNA

 
Description The JNK1 gene maps on chromosome 10q11.21 spanning 130089bp. It contains 22 confirmed introns, 20 of which are alternative.
Transcription By alternative splicing, JNK1 gene encodes 13 different transcripts that translate to 13 JNK1 isoforms. The predicted molecular weight of JNK1 protein is 44.2 kD.

Protein

Description All JNK proteins contain a protein kinase domain that belong to a very extensive family of eukaryotic serine/threonine proteins kinase. A number of conserved regions have been identified in the catalytic domain of JNKs. In the N-terminal extremity of the catalytic domain there is a glycine-rich motif in the vicinity of a lysine residue, which has been shown to be involved in ATP binding. A conserved aspartic acid reside that is critical for the catalytic activity of kinase has also been identified in the central part of the catalytic domain.
Expression JNK1 is ubiquitously expressed.
Localisation Cytoplasmic and nuclear
Function The members of JNK family act as an integration point for multiple intracellular biochemical signals governing a wide variety of cellular processes such as proliferation, differentiation, apoptosis, migration, transcriptional regulation, and development JNK targets specific transcription factors and thus mediates immediate-early gene expression in response to various stress signals including ultraviolet (UV) radiation, oxidative stress, protein malfolding in endoplasmic reticulum, osmotical shock, and inflammatory mediators. These transcription factors include AP-1, ATF-2, Elk-1, p53, etc... Several upstream dual specific protein kinases, such as MKK4/SEK1 and MKK7, can activate JNK through phosphorylation of the conversed Thr-Pro-Tyr motif on JNK proteins. In mammalian cells, activated JNK can phosphorylate the N-terminus of c-Jun, which contains both JNK docking site and JNK phosphorylation site (ser63 and ser73), orJunD, which lacks a JNK docking site but contains a JNK phosphorylation site. JNK is unable to phosphorylate JunB due to the lack of a JNK phosphorylation site inJunB, despite there is a functional JNK docking site. Comparison of the binding activity of JNK isoforms demonstrates that JNK2 bind c-Jun approximately 25 times more efficiently than did JNK1. Therefore, individual members of the JNK family may selectively target specific transcription factors in vivo. One of the most important functions of JNK is the regulation of apoptosis. Emerging evidence indicates that JNK activation is obligatory for apoptosis induced by both receptor-mediated "extrinsic" pathway or mitochondria-mediated "intrinsic" pathway. JNK activation may contribute to the initiation of Fas-induced apoptosis, possibly through the amplification of autocrine or paracrine Fas signaling by JNK-dependent Fas ligand (FasL) gene expression. In addition, JNK has been indicated in the apoptosis induced by Daxx, a Fas death domain (FADD) interaction protein. Through its serine/threonine kinase activity, JNK may contribute to mitochondria-mediated apoptosis by phosphorylating pro- or anti-apoptoticBcl-2 family proteins. Finally, JNK has also been indicated as an important kinase phosphorylating p53 and subsequently facilitating p53-dependent apoptotic responses. Sustained JNK activation may be responsible for the enhanced apoptosis observed in RelA-/- or Ikkb-/- mouse embryonic fibroblasts treated with TNFa. It was suggested that deficiency of RelA or IKKb caused a decreased expression of XIAP or GADD45b, which may antagonize the activation of JNK activation. However, such speculation contradicts the previous observations indicating that both GADD45b and XIAP are activators, rather than inhibitors for JNK activation. Moreover, gene profiling in our recent studies indicated no substantial difference of basal or inducible GADD45b and XIAP mRNA in wild type cells and Ikkb-/- cells.

Implicated in

Note
  
Entity Obesity, insulin resistance, neurodegenerative diseases, inflammation, cancer.
  

Bibliography

Signal transduction by the JNK group of MAP kinases.
Davis RJ
Cell. 2000 ; 103 (2) : 239-252.
PMID 11057897
 
Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.
De Smaele E, Zazzeroni F, Papa S, Nguyen DU, Jin R, Jones J, Cong R, Franzoso G
Nature. 2001 ; 414 (6861) : 308-313.
PMID 11713530
 
Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter.
Faris M, Latinis KM, Kempiak SJ, Koretzky GA, Nel A
Molecular and cellular biology. 1998 ; 18 (9) : 5414-5424.
PMID 9710625
 
JNK targets p53 ubiquitination and degradation in nonstressed cells.
Fuchs SY, Adler V, Buschmann T, Yin Z, Wu X, Jones SN, Ronai Z
Genes & development. 1998 ; 12 (17) : 2658-2663.
PMID 9732264
 
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase.
Jacobs D, Glossip D, Xing H, Muslin AJ, Kornfeld K
Genes & development. 1999 ; 13 (2) : 163-175.
PMID 9925641
 
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death.
Suzuki Y, Nakabayashi Y, Takahashi R
Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8662-8667.
PMID 11447297
 
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.
Takekawa M, Saito H
Cell. 1998 ; 95 (4) : 521-530.
PMID 9827804
 
Inhibition of JNK activation through NF-kappaB target genes.
Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A
Nature. 2001 ; 414 (6861) : 313-317.
PMID 11713531
 
Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
Yang X, Khosravi-Far R, Chang HY, Baltimore D
Cell. 1997 ; 89 (7) : 1067-1076.
PMID 9215629
 

Citation

This paper should be referenced as such :
Chen, F
MAPK8 (mitogen-activated protein kinase 8)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(2):88-89.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 15 ]
  dic(9;17)(p13;q11) PAX5::TAOK1
inv(3)(p12q26) ?::MECOM
inv(3)(q23q26) ?::MECOM
t(1;9)(p13;p12) PAX5::HIPK1
t(2;9)(p23;q33) TRAF1::ALK
t(3;3)(p24;q26) ?::MECOM
t(3;5)(q26;q34) ?::MECOM
t(3;6)(q25;q26) ?::MECOM
t(3;9)(q26;p23) ?::MECOM
t(3;11)(q26;p15) ?::MECOM
t(3;12)(q26;q21) ?::MECOM
t(3;17)(q26;q22) ?::MECOM
t(3;18)(q26;q11) ?::MECOM
t(4;10)(q12;p11) KIF5B::PDGFRA
t(5;9)(q33;q22) ITK::SYK


External links

 

Nomenclature
HGNC (Hugo)MAPK8   6881
Cards
AtlasJNK1ID196
Atlas Explorer : (Salamanque)MAPK8
Entrez_Gene (NCBI)MAPK8    mitogen-activated protein kinase 8
AliasesJNK; JNK-46; JNK1; JNK1A2; 
JNK21B1/2; PRKM8; SAPK1; SAPK1c
GeneCards (Weizmann)MAPK8
Ensembl hg19 (Hinxton)ENSG00000107643 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107643 [Gene_View]  ENSG00000107643 [Sequence]  chr10:48306677-48439359 [Contig_View]  MAPK8 [Vega]
ICGC DataPortalENSG00000107643
TCGA cBioPortalMAPK8
AceView (NCBI)MAPK8
Genatlas (Paris)MAPK8
SOURCE (Princeton)MAPK8
Genetics Home Reference (NIH)MAPK8
Genomic and cartography
GoldenPath hg38 (UCSC)MAPK8  -     chr10:48306677-48439359 +  10q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAPK8  -     10q11.22   [Description]    (hg19-Feb_2009)
GoldenPathMAPK8 - 10q11.22 [CytoView hg19]  MAPK8 - 10q11.22 [CytoView hg38]
ImmunoBaseENSG00000107643
Genome Data Viewer NCBIMAPK8 [Mapview hg19]  
OMIM601158   
Gene and transcription
Genbank (Entrez)AA808177 AB074280 AB451231 AB451271 AB451354
RefSeq transcript (Entrez)NM_001278547 NM_001278548 NM_001323302 NM_001323320 NM_001323321 NM_001323322 NM_001323323 NM_001323324 NM_001323325 NM_001323326 NM_001323327 NM_001323328 NM_001323329 NM_001323330 NM_001323331 NM_002750 NM_139046 NM_139049
Consensus coding sequences : CCDS (NCBI)MAPK8
Gene ExpressionMAPK8 [ NCBI-GEO ]   MAPK8 [ EBI - ARRAY_EXPRESS ]   MAPK8 [ SEEK ]   MAPK8 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPK8 [ Firebrowse - Broad ]
GenevisibleExpression of MAPK8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5599
GTEX Portal (Tissue expression)MAPK8
Human Protein AtlasENSG00000107643-MAPK8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP45983   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP45983  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP45983
PhosPhoSitePlusP45983
Domaine pattern : Prosite (Expaxy)MAPK (PS01351)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    MAP_kinase_CS    MAPK_JNK    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAPK8
PDB (RSDB)1UKH    1UKI    2G01    2GMX    2H96    2NO3    2XRW    2XS0    3ELJ    3O17    3O2M    3PZE    3V3V    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4AWI    4E73    4G1W    4HYS    4HYU    4IZY    4L7F    4QTD    4UX9    4YR8    5LW1    6F5E   
PDB Europe1UKH    1UKI    2G01    2GMX    2H96    2NO3    2XRW    2XS0    3ELJ    3O17    3O2M    3PZE    3V3V    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4AWI    4E73    4G1W    4HYS    4HYU    4IZY    4L7F    4QTD    4UX9    4YR8    5LW1    6F5E   
PDB (PDBSum)1UKH    1UKI    2G01    2GMX    2H96    2NO3    2XRW    2XS0    3ELJ    3O17    3O2M    3PZE    3V3V    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4AWI    4E73    4G1W    4HYS    4HYU    4IZY    4L7F    4QTD    4UX9    4YR8    5LW1    6F5E   
PDB (IMB)1UKH    1UKI    2G01    2GMX    2H96    2NO3    2XRW    2XS0    3ELJ    3O17    3O2M    3PZE    3V3V    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4AWI    4E73    4G1W    4HYS    4HYU    4IZY    4L7F    4QTD    4UX9    4YR8    5LW1    6F5E   
Structural Biology KnowledgeBase1UKH    1UKI    2G01    2GMX    2H96    2NO3    2XRW    2XS0    3ELJ    3O17    3O2M    3PZE    3V3V    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4AWI    4E73    4G1W    4HYS    4HYU    4IZY    4L7F    4QTD    4UX9    4YR8    5LW1    6F5E   
SCOP (Structural Classification of Proteins)1UKH    1UKI    2G01    2GMX    2H96    2NO3    2XRW    2XS0    3ELJ    3O17    3O2M    3PZE    3V3V    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4AWI    4E73    4G1W    4HYS    4HYU    4IZY    4L7F    4QTD    4UX9    4YR8    5LW1    6F5E   
CATH (Classification of proteins structures)1UKH    1UKI    2G01    2GMX    2H96    2NO3    2XRW    2XS0    3ELJ    3O17    3O2M    3PZE    3V3V    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4AWI    4E73    4G1W    4HYS    4HYU    4IZY    4L7F    4QTD    4UX9    4YR8    5LW1    6F5E   
SuperfamilyP45983
AlphaFold pdb e-kbP45983   
Human Protein Atlas [tissue]ENSG00000107643-MAPK8 [tissue]
HPRD03100
Protein Interaction databases
DIP (DOE-UCLA)P45983
IntAct (EBI)P45983
BioGRIDMAPK8
STRING (EMBL)MAPK8
ZODIACMAPK8
Ontologies - Pathways
QuickGOP45983
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  JUN kinase activity  JUN kinase activity  JUN kinase activity  MAP kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  protein phosphorylation  protein phosphorylation  response to oxidative stress  JNK cascade  JNK cascade  JUN phosphorylation  JUN phosphorylation  response to UV  response to mechanical stimulus  positive regulation of gene expression  regulation of macroautophagy  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-threonine phosphorylation  enzyme binding  protein phosphatase binding  axon  regulation of histone deacetylation  positive regulation of cyclase activity  positive regulation of cell killing  negative regulation of protein binding  regulation of protein localization  cellular response to amino acid starvation  cellular response to reactive oxygen species  histone deacetylase regulator activity  intracellular signal transduction  Fc-epsilon receptor signaling pathway  regulation of circadian rhythm  histone deacetylase binding  positive regulation of apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  synapse  rhythmic process  regulation of DNA-binding transcription factor activity  positive regulation of protein metabolic process  stress-activated MAPK cascade  cellular response to lipopolysaccharide  cellular response to mechanical stimulus  cellular response to cadmium ion  positive regulation of deacetylase activity  cellular senescence  basal dendrite  protein serine kinase activity  protein serine/threonine kinase binding  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of DNA replication origin binding  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  JUN kinase activity  JUN kinase activity  JUN kinase activity  MAP kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  protein phosphorylation  protein phosphorylation  response to oxidative stress  JNK cascade  JNK cascade  JUN phosphorylation  JUN phosphorylation  response to UV  response to mechanical stimulus  positive regulation of gene expression  regulation of macroautophagy  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-threonine phosphorylation  enzyme binding  protein phosphatase binding  axon  regulation of histone deacetylation  positive regulation of cyclase activity  positive regulation of cell killing  negative regulation of protein binding  regulation of protein localization  cellular response to amino acid starvation  cellular response to reactive oxygen species  histone deacetylase regulator activity  intracellular signal transduction  Fc-epsilon receptor signaling pathway  regulation of circadian rhythm  histone deacetylase binding  positive regulation of apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  synapse  rhythmic process  regulation of DNA-binding transcription factor activity  positive regulation of protein metabolic process  stress-activated MAPK cascade  cellular response to lipopolysaccharide  cellular response to mechanical stimulus  cellular response to cadmium ion  positive regulation of deacetylase activity  cellular senescence  basal dendrite  protein serine kinase activity  protein serine/threonine kinase binding  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of DNA replication origin binding  
Pathways : BIOCARTABIOCARTA_DSPPATHWAY    BIOCARTA_AGRPATHWAY    BIOCARTA_AT1RPATHWAY    BIOCARTA_ATMPATHWAY    BIOCARTA_BCRPATHWAY    BIOCARTA_BIOPEPTIDESPATHWAY    BIOCARTA_RANKLPATHWAY    BIOCARTA_CERAMIDEPATHWAY    BIOCARTA_EGFPATHWAY    BIOCARTA_EPOPATHWAY    BIOCARTA_FASPATHWAY    BIOCARTA_FCER1PATHWAY    BIOCARTA_HIVNEFPATHWAY    BIOCARTA_P53HYPOXIAPATHWAY    BIOCARTA_IGF1PATHWAY    BIOCARTA_IL2PATHWAY    BIOCARTA_IL12PATHWAY    BIOCARTA_GLEEVECPATHWAY    BIOCARTA_INSULINPATHWAY    BIOCARTA_INTEGRINPATHWAY    BIOCARTA_KERATINOCYTEPATHWAY    BIOCARTA_PYK2PATHWAY    BIOCARTA_MAPKPATHWAY    BIOCARTA_NGFPATHWAY    BIOCARTA_NFATPATHWAY    BIOCARTA_ARENRF2PATHWAY    BIOCARTA_PDGFPATHWAY    BIOCARTA_CCR5PATHWAY    BIOCARTA_MALPATHWAY    BIOCARTA_IL1RPATHWAY    BIOCARTA_METPATHWAY    BIOCARTA_TCRPATHWAY    BIOCARTA_TALL1PATHWAY    BIOCARTA_41BBPATHWAY    BIOCARTA_STRESSPATHWAY    BIOCARTA_TNFR1PATHWAY    BIOCARTA_TOLLPATHWAY   
Pathways : KEGGKEGG_MAPK_SIGNALING    KEGG_ERBB_SIGNALING    KEGG_WNT_SIGNALING    KEGG_FOCAL_ADHESION    KEGG_TOLL_LIKE_RECEPTOR_SIGNALING    KEGG_NOD_LIKE_RECEPTOR_SIGNALING    KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING    KEGG_FC_EPSILON_RI_SIGNALING    KEGG_NEUROTROPHIN_SIGNALING    KEGG_INSULIN_SIGNALING    KEGG_GNRH_SIGNALING    KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION    KEGG_ADIPOCYTOKINE_SIGNALING    KEGG_TYPE_II_DIABETES_MELLITUS    KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION    KEGG_PATHWAYS_IN_CANCER    KEGG_COLORECTAL_CANCER    KEGG_PANCREATIC_CANCER   
REACTOMEP45983 [protein]
REACTOME PathwaysR-HSA-9007892 [pathway]   
NDEx NetworkMAPK8
Atlas of Cancer Signalling NetworkMAPK8
Wikipedia pathwaysMAPK8
Orthology - Evolution
OrthoDB5599
GeneTree (enSembl)ENSG00000107643
Phylogenetic Trees/Animal Genes : TreeFamMAPK8
Homologs : HomoloGeneMAPK8
Homology/Alignments : Family Browser (UCSC)MAPK8
Gene fusions - Rearrangements
Fusion : MitelmanCOG6::MAPK8 [13q14.11/10q11.22]  
Fusion : MitelmanMAPK8::C10orf53 [10q11.22/10q11.23]  
Fusion : MitelmanMAPK8::KIRREL2 [10q11.22/19q13.12]  
Fusion : FusionGDB2.7.11.1   
Fusion : FusionHubADK--MAPK8    AMN1--MAPK8    ATAD1--MAPK8    BICC1--MAPK8    COG6--MAPK8    GOLIM4--MAPK8    LARGE--MAPK8    MAP3K4--MAPK8    MAPK10--MAPK8    MAPK8--APPBP2   
MAPK8--ARFIP1    MAPK8--C10ORF53    MAPK8--CADPS2    MAPK8--DYNC1I2    MAPK8--INPP5A    MAPK8--KIRREL2    MAPK8--LOC284998    MAPK8--MAP3K8    MAPK8--MAPK10    MAPK8--PRKG1   
MAPK8--PSMD1    MAPK8--RAP1B    MAPK8--RFX3    MAPK8--SGMS1    MLLT4--MAPK8    PHF20L1--MAPK8    SLC26A5--MAPK8    TOM1L2--MAPK8    USP10--MAPK8    ZNF37A--MAPK8   
Fusion : QuiverMAPK8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPK8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPK8
dbVarMAPK8
ClinVarMAPK8
MonarchMAPK8
1000_GenomesMAPK8 
Exome Variant ServerMAPK8
GNOMAD BrowserENSG00000107643
Varsome BrowserMAPK8
ACMGMAPK8 variants
VarityP45983
Genomic Variants (DGV)MAPK8 [DGVbeta]
DECIPHERMAPK8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAPK8 
Mutations
ICGC Data PortalMAPK8 
TCGA Data PortalMAPK8 
Broad Tumor PortalMAPK8
OASIS PortalMAPK8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAPK8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAPK8
Mutations and Diseases : HGMDMAPK8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAPK8
DgiDB (Drug Gene Interaction Database)MAPK8
DoCM (Curated mutations)MAPK8
CIViC (Clinical Interpretations of Variants in Cancer)MAPK8
Cancer3DMAPK8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601158   
Orphanet
DisGeNETMAPK8
MedgenMAPK8
Genetic Testing Registry MAPK8
NextProtP45983 [Medical]
GENETestsMAPK8
Target ValidationMAPK8
Huge Navigator MAPK8 [HugePedia]
ClinGenMAPK8
Clinical trials, drugs, therapy
MyCancerGenomeMAPK8
Protein Interactions : CTDMAPK8
Pharm GKB GenePA283
Pharm GKB PathwaysPA162356267   PA165985892   PA2032   
PharosP45983
Clinical trialMAPK8
Miscellaneous
canSAR (ICR)MAPK8
HarmonizomeMAPK8
ARCHS4MAPK8
DataMed IndexMAPK8
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAPK8
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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