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LIN28B (lin-28 homolog B (C. elegans))

Written2011-07Yung-Ming Jeng
Department of Biochemistry, Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan

(Note : for Links provided by Atlas : click)


HGNC (Hugo) LIN28B
HGNC Alias symbFLJ16517
HGNC Previous namelin-28 homolog B (C. elegans)
LocusID (NCBI) 389421
Atlas_Id 45723
Location 6q16.3  [Link to chromosome band 6q16]
Location_base_pair Starts at 104957107 and ends at 105083332 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping LIN28B.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LIN28B (6q16.3)::STX7 (6q23.2)
Note Size: 146,72 kb. Orientation: plus strand.


Description The gene spans over 125 kb on plus strand; 4 exons.
Transcription The gene is mainly expressed in fetal tissues and not expressed in adult tissue and reexpressed in cancer tissue.


Description Lin28B is an oncofetal RNA-binding protein. Lin-28B protein consists of two domains that contain RNA-binding motif: the N-terminal cold shock domain and a pair of retroviral-type CCHC zinc fingers. It inhibits biosynthesis of let-7 microRNA through binding to the 5'-GGAG-3' motif in the terminal loop of pre-let-7 and promoting terminal uridylation of let-7 precusor by . Uridylated pre-let-7 miRNAs fail to be processed by and undergo degradation.
Expression Cytoplasm.
Function It inhibits biosynthesis of let-7 microRNA through promoting terminal uridylation of let-7 precusor by TUTase4.


Note No somatic mutation of Lin28B was identified in cancer.

Implicated in

Entity Hepatocellular carcinoma
Note Lin28B expression is more frequently noted in high-grade hepatocellular carcinoma with high alpha-fetoprotein levels. Knockdown of Lin28B by RNA interference in the HCC cell line suppressed proliferation in vitro and reduced in vivo tumor growth in NOD/SCID mice. In contrast, overexpression of Lin28B in the HCC cell line enhanced tumorigenicity. Overexpression of Lin28B also induced epithelial-mesenchymal transition in HA22T cells and hence, invasion capacity.
Entity Colorectal cancer
Note Lin28B is overexpressed in colorectal cancer. It promotes cell migration, invasion and transforms immortalized colonic epithelial cells. In addition, constitutive LIN28B expression increases expression of intestinal stem cell markers LGR5 and PROM1 in the presence of let-7 restoration.
Entity Ovarian cancer
Note Lin28B is overexpressed in high grade serous ovarian cancer. Pleomorphism in Lin28B promoter region is associated with susceptibility to epithelium ovarian cancer. Patients with high Lin28B ovarian cancer had shorter progression-free and overall survival than those with low Lin28B ovarian cancer.
Entity Age at menarche
Note A sequence variation in Lin28B is identified as the SNP most significant associated with age at menarche in one genome wide study. Besides, a meta-analysis of 32 genome-wide association studies in 87802 women found polymorphism of Lin28B is strongly associated with age at menarche. Knockout mice of Lin28B also show delay in puberty onset.
Entity Body height
Note A LIN28B SNP, rs314277, is associated with final body height.


Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
He C, Kraft P, Chen C, Buring JE, Pare G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI.
Nat Genet. 2009 Jun;41(6):724-8. Epub 2009 May 17.
PMID 19448621
Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.
Helland A, Anglesio MS, George J, Cowin PA, Johnstone CN, House CM, Sheppard KE, Etemadmoghadam D, Melnyk N, Rustgi AK, Phillips WA, Johnsen H, Holm R, Kristensen GB, Birrer MJ; Australian Ovarian Cancer Study Group, Pearson RB, Borresen-Dale AL, Huntsman DG, deFazio A, Creighton CJ, Smyth GK, Bowtell DD.
PLoS One. 2011 Apr 13;6(4):e18064.
PMID 21533284
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.
Heo I, Joo C, Cho J, Ha M, Han J, Kim VN.
Mol Cell. 2008 Oct 24;32(2):276-84.
PMID 18951094
LIN28B promotes colon cancer progression and metastasis.
King CE, Cuatrecasas M, Castells A, Sepulveda AR, Lee JS, Rustgi AK.
Cancer Res. 2011 Jun 15;71(12):4260-8. Epub 2011 Apr 21.
PMID 21512136
LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms.
King CE, Wang L, Winograd R, Madison BB, Mongroo PS, Johnstone CN, Rustgi AK.
Oncogene. 2011 May 30. [Epub ahead of print]
PMID 21625210
Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II.
Lu L, Katsaros D, Shaverdashvili K, Qian B, Wu Y, de la Longrais IA, Preti M, Menato G, Yu H.
Eur J Cancer. 2009 Aug;45(12):2212-8. Epub 2009 May 26.
PMID 19477633
Lin28 promotes transformation and is associated with advanced human malignancies.
Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O'Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ.
Nat Genet. 2009 Jul;41(7):843-8. Epub 2009 May 31.
PMID 19483683


This paper should be referenced as such :
Jeng, YM. LIN28B (lin-28 homolog B (C
Atlas Genet Cytogenet Oncol Haematol. 2012;16(1):20-21.
Free journal version : [ pdf ]   [ DOI ]

External links


HGNC (Hugo)LIN28B   32207
Entrez_Gene (NCBI)LIN28B    lin-28 homolog B
GeneCards (Weizmann)LIN28B
Ensembl hg19 (Hinxton)ENSG00000187772 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187772 [Gene_View]  ENSG00000187772 [Sequence]  chr6:104957107-105083332 [Contig_View]  LIN28B [Vega]
ICGC DataPortalENSG00000187772
TCGA cBioPortalLIN28B
AceView (NCBI)LIN28B
Genatlas (Paris)LIN28B
SOURCE (Princeton)LIN28B
Genetics Home Reference (NIH)LIN28B
Genomic and cartography
GoldenPath hg38 (UCSC)LIN28B  -     chr6:104957107-105083332 +  6q16.3-q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LIN28B  -     6q16.3-q21   [Description]    (hg19-Feb_2009)
GoldenPathLIN28B - 6q16.3-q21 [CytoView hg19]  LIN28B - 6q16.3-q21 [CytoView hg38]
Genome Data Viewer NCBILIN28B [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK131411 AW674597 BC127712 BC127713 BC137526
RefSeq transcript (Entrez)NM_001004317
Consensus coding sequences : CCDS (NCBI)LIN28B
Gene ExpressionLIN28B [ NCBI-GEO ]   LIN28B [ EBI - ARRAY_EXPRESS ]   LIN28B [ SEEK ]   LIN28B [ MEM ]
Gene Expression Viewer (FireBrowse)LIN28B [ Firebrowse - Broad ]
GenevisibleExpression of LIN28B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)389421
GTEX Portal (Tissue expression)LIN28B
Human Protein AtlasENSG00000187772-LIN28B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZN17   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZN17  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZN17
Domaine pattern : Prosite (Expaxy)CSD_2 (PS51857)    ZF_CCHC (PS50158)   
Domains : Interpro (EBI)CSD    CSP_DNA-bd    NA-bd_OB-fold    Znf_CCHC    Znf_CCHC_sf   
Domain families : Pfam (Sanger)CSD (PF00313)    zf-CCHC (PF00098)   
Domain families : Pfam (NCBI)pfam00313    pfam00098   
Domain families : Smart (EMBL)CSP (SM00357)  ZnF_C2HC (SM00343)  
Conserved Domain (NCBI)LIN28B
PDB Europe4A4I   
PDB (PDBSum)4A4I   
PDB (IMB)4A4I   
Structural Biology KnowledgeBase4A4I   
SCOP (Structural Classification of Proteins)4A4I   
CATH (Classification of proteins structures)4A4I   
AlphaFold pdb e-kbQ6ZN17   
Human Protein Atlas [tissue]ENSG00000187772-LIN28B [tissue]
Protein Interaction databases
IntAct (EBI)Q6ZN17
Ontologies - Pathways
Ontology : AmiGORNA binding  RNA binding  protein binding  nucleoplasm  nucleolus  cytosol  zinc ion binding  miRNA catabolic process  pre-miRNA processing  RNA 3'-end processing  RNA destabilization  sequence-specific double-stranded DNA binding  positive regulation of miRNA catabolic process  negative regulation of pre-miRNA processing  negative regulation of primary miRNA processing  
Ontology : EGO-EBIRNA binding  RNA binding  protein binding  nucleoplasm  nucleolus  cytosol  zinc ion binding  miRNA catabolic process  pre-miRNA processing  RNA 3'-end processing  RNA destabilization  sequence-specific double-stranded DNA binding  positive regulation of miRNA catabolic process  negative regulation of pre-miRNA processing  negative regulation of primary miRNA processing  
NDEx NetworkLIN28B
Atlas of Cancer Signalling NetworkLIN28B
Wikipedia pathwaysLIN28B
Orthology - Evolution
GeneTree (enSembl)ENSG00000187772
Phylogenetic Trees/Animal Genes : TreeFamLIN28B
Homologs : HomoloGeneLIN28B
Homology/Alignments : Family Browser (UCSC)LIN28B
Gene fusions - Rearrangements
Fusion : MitelmanLIN28B::STX7 [6q16.3/6q23.2]  
Fusion : QuiverLIN28B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIN28B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIN28B
Exome Variant ServerLIN28B
GNOMAD BrowserENSG00000187772
Varsome BrowserLIN28B
ACMGLIN28B variants
Genomic Variants (DGV)LIN28B [DGVbeta]
DECIPHERLIN28B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLIN28B 
ICGC Data PortalLIN28B 
TCGA Data PortalLIN28B 
Broad Tumor PortalLIN28B
OASIS PortalLIN28B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIN28B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLIN28B
Mutations and Diseases : HGMDLIN28B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)LIN28B
DoCM (Curated mutations)LIN28B
CIViC (Clinical Interpretations of Variants in Cancer)LIN28B
NCG (London)LIN28B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry LIN28B
NextProtQ6ZN17 [Medical]
Target ValidationLIN28B
Huge Navigator LIN28B [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDLIN28B
Pharm GKB GenePA142671543
Clinical trialLIN28B
DataMed IndexLIN28B
PubMed164 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:21:17 CEST 2021

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