Fusion genes
(updated 2016) | BACE2 (21q22.2) / LASP1 (17q12) | CTTN (11q13.3) / LASP1 (17q12) | KMT2A (11q23.3) / LASP1 (17q12) |
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LASP1 (17q12) / BCL2L2-PABPN1 (14q11.2) | LASP1 (17q12) / CPXM1 (20p13) | LASP1 (17q12) / EEF1A1 (6q13) |
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LASP1 (17q12) / KMT2A (11q23.3) | LASP1 (17q12) / LASP1 (17q12) | LASP1 (17q12) / LINC00672 (17q12) |
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LASP1 (17q12) / MTMR1 (Xq28) | LASP1 (17q12) / PPP1R1B (17q12) | LASP1 (17q12) / RHBDL3 (17q11.2) |
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RPL28 (19q13.42) / LASP1 (17q12) | TRPS1 (8q23.3) / LASP1 (17q12) | UBA1 (Xp11.23) / LASP1 (17q12) |
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| Description | 261 amino acids; 29 kDa. LASP1 encodes a member of a LIM (Lin-11, Isl-1 and Mec-3) protein subfamily and is characterized by a LIM motif (cysteine-rich LIM/double zinc finger motif) at the N-terminus, an SH3 domain (Src homology region 3) at the C-terminus, and two actin-binding domains in the core of the protein |
| Expression | ubiquitous |
| Localisation | intracellular, cytoplasmic; associated with the F-actin rich cortical cytoskeleton |
| Function | LASP1 plays an important role in the regulation of dynamic actin-based, cytoskeletal activities and cell motility. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types. Together, (LIM-) nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions. |
| Homology | LASP family of proteins: actin-binding repeats similar to those in LASP1 are also present in other nebulin-related proteins such as NEBL (nebulette, 107 kD actin-binding Z-disk protein) and NRAP (nebulin-related anchoring protein); NRAP also contains an N-terminal LIM domain and NEB (nebulin) a C-terminal SH3 domain, both of which are highly homologous to the respective domains of LASP1. |
| Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer. |
| Bièche I, Tomasetto C, Régnier CH, Moog-Lutz C, Rio MC, Lidereau R |
| Cancer research. 1996 ; 56 (17) : 3886-3890. |
| PMID 8752152 |
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| Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146. |
| Butt E, Gambaryan S, Göttfert N, Galler A, Marcus K, Meyer HE |
| The Journal of biological chemistry. 2003 ; 278 (18) : 15601-15607. |
| PMID 12571245 |
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| Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo. |
| Chew CS, Chen X, Parente JA Jr, Tarrer S, Okamoto C, Qin HY |
| Journal of cell science. 2002 ; 115 (Pt 24) : 4787-4799. |
| PMID 12432067 |
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| The LIM and SH3 domain-containing protein, lasp-1, may link the cAMP signaling pathway with dynamic membrane restructuring activities in ion transporting epithelia. |
| Chew CS, Parente JA Jr, Chen X, Chaponnier C, Cameron RS |
| Journal of cell science. 2000 ; 113 ( Pt 11) : 2035-2045. |
| PMID 10806114 |
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| Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. |
| Keicher C, Gambaryan S, Schulze E, Marcus K, Meyer HE, Butt E |
| Biochemical and biophysical research communications. 2004 ; 324 (1) : 308-316. |
| PMID 15465019 |
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| Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. |
| Li B, Zhuang L, Trueb B |
| The Journal of biological chemistry. 2004 ; 279 (19) : 20401-20410. |
| PMID 15004028 |
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| Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. |
| Lin YH, Park ZY, Lin D, Brahmbhatt AA, Rio MC, Yates JR 3rd, Klemke RL |
| The Journal of cell biology. 2004 ; 165 (3) : 421-432. |
| PMID 15138294 |
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| Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines. |
| Phillips GR, Anderson TR, Florens L, Gudas C, Magda G, Yates JR 3rd, Colman DR |
| Journal of neuroscience research. 2004 ; 78 (1) : 38-48. |
| PMID 15372503 |
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| Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. |
| Schreiber V, Moog-Lutz C, Régnier CH, Chenard MP, Boeuf H, Vonesch JL, Tomasetto C, Rio MC |
| Molecular medicine (Cambridge, Mass.). 1998 ; 4 (10) : 675-687. |
| PMID 9848085 |
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| The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21). |
| Strehl S, Borkhardt A, Slany R, Fuchs UE, König M, Haas OA |
| Oncogene. 2003 ; 22 (1) : 157-160. |
| PMID 12527918 |
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| Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |
| Tomasetto C, Régnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC |
| Genomics. 1995 ; 28 (3) : 367-376. |
| PMID 7490069 |
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