LASP1 (LIM and SH3 protein)
2005-08-01 Sabine Strehl AffiliationChildrens Cancer Research Institute, Kinderspitalgasse 6, A-1090 Vienna, Austria
DNA/RNA
Description
LASP1 encompasses 51.65 kb on the genomic level and consists of 7 exons
Transcription
3845 bp mRNA, 783 bp coding sequence
Proteins
Description
261 amino acids; 29 kDa. LASP1 encodes a member of a LIM (Lin-11, Isl-1 and Mec-3) protein subfamily and is characterized by a LIM motif (cysteine-rich LIM/double zinc finger motif) at the N-terminus, an SH3 domain (Src homology region 3) at the C-terminus, and two actin-binding domains in the core of the protein
Expression
ubiquitous
Localisation
intracellular, cytoplasmic; associated with the F-actin rich cortical cytoskeleton
Function
LASP1 plays an important role in the regulation of dynamic actin-based, cytoskeletal activities and cell motility. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types. Together, (LIM-) nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions.
Homology
LASP family of proteins: actin-binding repeats similar to those in LASP1 are also present in other nebulin-related proteins such as NEBL (nebulette, 107 kD actin-binding Z-disk protein) and NRAP (nebulin-related anchoring protein); NRAP also contains an N-terminal LIM domain and NEB (nebulin) a C-terminal SH3 domain, both of which are highly homologous to the respective domains of LASP1.
Implicated in
Entity name
Disease
infant AML-M4; only one case described so far
Fusion protein
the MLL-LASP1 chimeric protein consists of the AT-hook DNA-binding domain and the methyltransferase motif including the CXXC zinc-finger domain of MLL and the SH3 domain of LASP1
Entity name
breast carcinomas
Disease
17q11-q21 amplification is found in about 25% of primary breast carcinomas; simultaneous amplification and overexpression of LASP1 and ERBB2
Prognosis
poor clinical outcome; increase risk of relapse
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8752152 | 1996 | Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer. | Bièche I et al |
| 12571245 | 2003 | Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146. | Butt E et al |
| 12432067 | 2002 | Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo. | Chew CS et al |
| 10806114 | 2000 | The LIM and SH3 domain-containing protein, lasp-1, may link the cAMP signaling pathway with dynamic membrane restructuring activities in ion transporting epithelia. | Chew CS et al |
| 15465019 | 2004 | Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. | Keicher C et al |
| 15004028 | 2004 | Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. | Li B et al |
| 15138294 | 2004 | Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. | Lin YH et al |
| 15372503 | 2004 | Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines. | Phillips GR et al |
| 9848085 | 1998 | Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. | Schreiber V et al |
| 12527918 | 2003 | The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21). | Strehl S et al |
| 7490069 | 1995 | Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. | Tomasetto C et al |
Other Information
Locus ID:
NCBI: 3927
MIM: 602920
HGNC: 6513
Ensembl: ENSG00000002834
Variants:
dbSNP: 3927
ClinVar: 3927
TCGA: ENSG00000002834
COSMIC: LASP1
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38713618 | 2024 | Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway. | 0 |
| 38713618 | 2024 | Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway. | 0 |
| 36394255 | 2023 | Circular RNA hsa_circ_0003892 promotes the development of papillary thyroid carcinoma by regulating the miR-326/LASP1 axis. | 2 |
| 36670097 | 2023 | TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs. | 2 |
| 36394255 | 2023 | Circular RNA hsa_circ_0003892 promotes the development of papillary thyroid carcinoma by regulating the miR-326/LASP1 axis. | 2 |
| 36670097 | 2023 | TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs. | 2 |
| 34024023 | 2022 | Circular RNA circ_0006948 Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating microRNA-3612/LASP1 Axis. | 6 |
| 34875555 | 2022 | MiR-665 suppresses the progression of diffuse large B cell lymphoma (DLBCL) through targeting LIM and SH3 protein 1 (LASP1). | 4 |
| 34881777 | 2022 | LASP-1 interacts with ErbB2 in ovarian cancer cells. | 1 |
| 35081873 | 2022 | Long non-coding RNA (lncRNA) CYTOR promotes hepatocellular carcinoma proliferation by targeting the microRNA-125a-5p/LASP1 axis. | 12 |
| 35285372 | 2022 | Circ_0075804 Regulates the Expression of LASP1 by Targeting miR-1287-5p and Thus Affects the Biological Process of Retinoblastoma. | 0 |
| 35312115 | 2022 | Hsa_circ_0007142 contributes to cisplatin resistance in esophageal squamous cell carcinoma via miR-494-3p/LASP1 axis. | 9 |
| 35379225 | 2022 | miR-218-5p in endometrial microenvironment prevents the migration of ectopic endometrial stromal cells by inhibiting LASP1. | 1 |
| 35507100 | 2022 | LIM and SH3 protein 1 (LASP1) differentiates malignant chordomas from less malignant chondrosarcomas. | 1 |
| 35777805 | 2022 | CERS6-AS1 Facilitates Oncogenesis and Restrains Ferroptosis in Papillary Thyroid Carcinoma by Serving as a ceRNA through miR-497-5p/LASP1 Axis. | 4 |
Citation
Sabine Strehl
LASP1 (LIM and SH3 protein)
Atlas Genet Cytogenet Oncol Haematol. 2005-08-01
Online version: http://atlasgeneticsoncology.org/gene/203/lasp1-(lim-and-sh3-protein)
Historical Card
2000-03-01 LASP1 (LIM and SH3 protein) by Marie-Christine Rio Affiliation
I.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France
