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MTA1 (metastasis-associated gene 1)

Written2005-04Yasushi Toh, Garth L Nicolson
Department of Gastroenterological Surgery National Kyushu Cancer, Center Fukuoka, 811-1395, Japan

(Note : for Links provided by Atlas : click)

Identity

Other alias
HGNC (Hugo) MTA1
LocusID (NCBI) 9112
Atlas_Id 41443
Location 14q32.33  [Link to chromosome band 14q32]
Location_base_pair Starts at 105419849 and ends at 105470720 bp from pter ( according to hg19-Feb_2009)  [Mapping MTA1.png]
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRK2 (11q13.2) / MTA1 (14q32.33)MTA1 (14q32.33) / ABHD2 (15q26.1)MTA1 (14q32.33) / DPF3 (14q24.2)
MTA1 (14q32.33) / MTA1 (14q32.33)MTA1 (14q32.33) / PACS2 (14q32.33)
Note MTA1 gene was identified as a novel candidate metastasis-associated gene involved in cancer metastasis by differential cDNA library screening using the 13762NF rat mammary adenocarcinoma metastatic system. Its human homologue, MTA1 was also identified.

DNA/RNA

Transcription About 2.7 k mRNA; Protein coding region of 714 amino acid residues.

Protein

 
  Motifs in putative amino acid sequence of MTA1.
A leucine zipper motif and a GATA-type zinc finger motif are found near the mid-portion of the protein. Between them, a SANT domain is found which is homologous to the DNA binding domain of the myb oncogene family. In the amino terminal 200 amino acid residues, there are two highly acidic regions characteristic of the acidic activation domains of many transcription factors. At the carboxyl-terminus is a proline rich stretch whose sequence matches the consensus sequence of the src-homology 3-binding motif. Three putative nuclear localization signals are also present in the sequence.
Description 715 amino acids; about 80 kDa.
Expression Found in almost all tissues; most abundantly expressed in testis.
Localisation Nucleus.
Function MTA1 protein physically interacts with histone deacetylase 1 and is included in a protein nucleosome remodeling complex, NuRD (nucleosome remodeling and histone deacetylation). This protein complex, containing histone deacetylase, plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control.
Homology MTA2, MTA3.

Implicated in

Note
Disease Cancer invasion and metastasis as follows:
  • Overexpression of MTA1 mRNA is correlated with the depth of invasion and lymph node metastasis in gastric and colorectal carcinomas as well as in esophageal carcinomas. The correlation of overexpression of this gene is also reported in lung cancer, thymoma and prostate cancer.
  • Overexpression of MTA1 protein might be a useful predictor for poor prognosis of human esophageal squamous cell carcinomas.
  • Forced expression of the MTA1 protein in breast cancer cell line MCF-7 is accompanied by enhancement of the ability of cells to invade an artificial matrix and to grow in an anchorage-independent manner.
  • Increasing MTA1 expression enhances migration, invasion and anchorage-independent survival of immortalized human keratinocytes.
    •   

    Bibliography

    Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization.
    Cui Q, Takiguchi S, Matsusue K, Toh Y, Yoshida MA
    Cytogenetics and cell genetics. 2001 ; 93 (1-2) : 139-140.
    PMID 11474200
     
    MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.
    Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA
    Cell. 2003 ; 113 (2) : 207-219.
    PMID 12705869
     
    The role of metastasis-associated protein 1 in prostate cancer progression.
    Hofer MD, Kuefer R, Varambally S, Li H, Ma J, Shapiro GI, Gschwend JE, Hautmann RE, Sanda MG, Giehl K, Menke A, Chinnaiyan AM, Rubin MA
    Cancer research. 2004 ; 64 (3) : 825-829.
    PMID 14871807
     
    Emerging roles of MTA family members in human cancers.
    Kumar R, Wang RA, Bagheri-Yarmand R
    Seminars in oncology. 2003 ; 30 (5 Suppl 16) : 30-37.
    PMID 14613024
     
    Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes.
    Mahoney MG, Simpson A, Jost M, Noé M, Kari C, Pepe D, Choi YW, Uitto J, Rodeck U
    Oncogene. 2002 ; 21 (14) : 2161-2170.
    PMID 11948399
     
    Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor.
    Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M, Vadlamudi RK, Kumar R
    Nature cell biology. 2001 ; 3 (1) : 30-37.
    PMID 11146623
     
    Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides.
    Nawa A, Nishimori K, Lin P, Maki Y, Moue K, Sawada H, Toh Y, Fumitaka K, Nicolson GL
    Journal of cellular biochemistry. 2000 ; 79 (2) : 202-212.
    PMID 10967548
     
    Expression of the MTA1 mRNA in advanced lung cancer.
    Sasaki H, Moriyama S, Nakashima Y, Kobayashi Y, Yukiue H, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y
    Lung cancer (Amsterdam, Netherlands). 2002 ; 35 (2) : 149-154.
    PMID 11804687
     
    Expression of the MTA1 mRNA in thymoma patients.
    Sasaki H, Yukiue H, Kobayashi Y, Nakashima Y, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y
    Cancer letters. 2001 ; 174 (2) : 159-163.
    PMID 11689291
     
    Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1.
    Toh Y, Kuninaka S, Endo K, Oshiro T, Ikeda Y, Nakashima H, Baba H, Kohnoe S, Okamura T, Nicolson GL, Sugimachi K
    Journal of experimental & clinical cancer research : CR. 2000 ; 19 (1) : 105-111.
    PMID 10840944
     
    Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas.
    Toh Y, Kuwano H, Mori M, Nicolson GL, Sugimachi K
    British journal of cancer. 1999 ; 79 (11-12) : 1723-1726.
    PMID 10206283
     
    Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas.
    Toh Y, Ohga T, Endo K, Adachi E, Kusumoto H, Haraguchi M, Okamura T, Nicolson GL
    International journal of cancer. Journal international du cancer. 2004 ; 110 (3) : 362-367.
    PMID 15095300
     
    Overexpression of the MTA1 gene in gastrointestinal carcinomas: correlation with invasion and metastasis.
    Toh Y, Oki E, Oda S, Tokunaga E, Ohno S, Maehara Y, Nicolson GL, Sugimachi K
    International journal of cancer. Journal international du cancer. 1997 ; 74 (4) : 459-463.
    PMID 9291440
     
    A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses.
    Toh Y, Pencil SD, Nicolson GL
    The Journal of biological chemistry. 1994 ; 269 (37) : 22958-22963.
    PMID 8083195
     
    NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.
    Xue Y, Wong J, Moreno GT, Young MK, Côté J, Wang W
    Molecular cell. 1998 ; 2 (6) : 851-861.
    PMID 9885572
     

    Citation

    This paper should be referenced as such :
    Toh, Y ; Nicolson, GL
    MTA1 (metastasis-associated gene 1)
    Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):214-215.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Genes/MTA1ID41443ch14q32.html

    Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
      MTA1/PACS2 (14q32)

    External links

    Nomenclature
    HGNC (Hugo)MTA1   7410
    Cards
    AtlasMTA1ID41443ch14q32
    Entrez_Gene (NCBI)MTA1  9112  metastasis associated 1
    Aliases
    GeneCards (Weizmann)MTA1
    Ensembl hg19 (Hinxton)ENSG00000182979 [Gene_View]
    Ensembl hg38 (Hinxton)ENSG00000182979 [Gene_View]  ENSG00000182979 [Sequence]  chr14:105419849-105470720 [Contig_View]  MTA1 [Vega]
    ICGC DataPortalENSG00000182979
    TCGA cBioPortalMTA1
    AceView (NCBI)MTA1
    Genatlas (Paris)MTA1
    WikiGenes9112
    SOURCE (Princeton)MTA1
    Genetics Home Reference (NIH)MTA1
    Genomic and cartography
    GoldenPath hg38 (UCSC)MTA1  -     chr14:105419849-105470720 +  14q32.33   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)MTA1  -     14q32.33   [Description]    (hg19-Feb_2009)
    EnsemblMTA1 - 14q32.33 [CytoView hg19]  MTA1 - 14q32.33 [CytoView hg38]
    Mapping of homologs : NCBIMTA1 [Mapview hg19]  MTA1 [Mapview hg38]
    OMIM603526   
    Gene and transcription
    Genbank (Entrez)AB209348 AF508978 AW732089 BC006177 BC009443
    RefSeq transcript (Entrez)NM_001203258 NM_004689
    RefSeq genomic (Entrez)
    Consensus coding sequences : CCDS (NCBI)MTA1
    Cluster EST : UnigeneHs.525629 [ NCBI ]
    CGAP (NCI)Hs.525629
    Alternative Splicing GalleryENSG00000182979
    Gene ExpressionMTA1 [ NCBI-GEO ]   MTA1 [ EBI - ARRAY_EXPRESS ]   MTA1 [ SEEK ]   MTA1 [ MEM ]
    Gene Expression Viewer (FireBrowse)MTA1 [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)9112
    GTEX Portal (Tissue expression)MTA1
    Human Protein AtlasENSG00000182979-MTA1 [pathology]   [cell]   [tissue]
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtQ13330   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
    NextProtQ13330  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProQ13330
    Splice isoforms : SwissVarQ13330
    PhosPhoSitePlusQ13330
    Domaine pattern : Prosite (Expaxy)BAH (PS51038)    ELM2 (PS51156)    SANT (PS51293)   
    Domains : Interpro (EBI)BAH_dom    ELM2_dom    Homeobox-like_sf    MTA1_R1    SANT/Myb    SANT_dom    Znf_GATA   
    Domain families : Pfam (Sanger)BAH (PF01426)    ELM2 (PF01448)    GATA (PF00320)    MTA_R1 (PF17226)    Myb_DNA-binding (PF00249)   
    Domain families : Pfam (NCBI)pfam01426    pfam01448    pfam00320    pfam17226    pfam00249   
    Domain families : Smart (EMBL)BAH (SM00439)  ELM2 (SM01189)  SANT (SM00717)  ZnF_GATA (SM00401)  
    Conserved Domain (NCBI)MTA1
    DMDM Disease mutations9112
    Blocks (Seattle)MTA1
    PDB (SRS)4BKX    4PBY    4PBZ    4PC0    5FXY    5ICN   
    PDB (PDBSum)4BKX    4PBY    4PBZ    4PC0    5FXY    5ICN   
    PDB (IMB)4BKX    4PBY    4PBZ    4PC0    5FXY    5ICN   
    PDB (RSDB)4BKX    4PBY    4PBZ    4PC0    5FXY    5ICN   
    Structural Biology KnowledgeBase4BKX    4PBY    4PBZ    4PC0    5FXY    5ICN   
    SCOP (Structural Classification of Proteins)4BKX    4PBY    4PBZ    4PC0    5FXY    5ICN   
    CATH (Classification of proteins structures)4BKX    4PBY    4PBZ    4PC0    5FXY    5ICN   
    SuperfamilyQ13330
    Human Protein Atlas [tissue]ENSG00000182979-MTA1 [tissue]
    Peptide AtlasQ13330
    HPRD04633
    IPIIPI00012773   IPI00215764   IPI00879971   IPI01015920   IPI01022533   IPI01022811   IPI01022978   IPI00879374   IPI00879166   IPI00879521   IPI00879781   
    Protein Interaction databases
    DIP (DOE-UCLA)Q13330
    IntAct (EBI)Q13330
    FunCoupENSG00000182979
    BioGRIDMTA1
    STRING (EMBL)MTA1
    ZODIACMTA1
    Ontologies - Pathways
    QuickGOQ13330
    Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, transcription factor binding  core promoter sequence-specific DNA binding  RNA polymerase II repressing transcription factor binding  RNA polymerase II repressing transcription factor binding  chromatin binding  transcription coactivator activity  transcription coactivator activity  transcription corepressor activity  transcription corepressor activity  histone deacetylase activity  protein binding  nucleus  nucleus  nuclear envelope  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  microtubule  double-strand break repair  double-strand break repair  transcription, DNA-templated  regulation of transcription by RNA polymerase II  signal transduction  zinc ion binding  response to ionizing radiation  response to ionizing radiation  histone deacetylation  histone deacetylation  NuRD complex  NuRD complex  circadian regulation of gene expression  regulation of gene expression, epigenetic  histone deacetylase binding  entrainment of circadian clock by photoperiod  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  locomotor rhythm  positive regulation of protein autoubiquitination  negative regulation of nucleic acid-templated transcription  positive regulation of nucleic acid-templated transcription  
    Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, transcription factor binding  core promoter sequence-specific DNA binding  RNA polymerase II repressing transcription factor binding  RNA polymerase II repressing transcription factor binding  chromatin binding  transcription coactivator activity  transcription coactivator activity  transcription corepressor activity  transcription corepressor activity  histone deacetylase activity  protein binding  nucleus  nucleus  nuclear envelope  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  microtubule  double-strand break repair  double-strand break repair  transcription, DNA-templated  regulation of transcription by RNA polymerase II  signal transduction  zinc ion binding  response to ionizing radiation  response to ionizing radiation  histone deacetylation  histone deacetylation  NuRD complex  NuRD complex  circadian regulation of gene expression  regulation of gene expression, epigenetic  histone deacetylase binding  entrainment of circadian clock by photoperiod  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  locomotor rhythm  positive regulation of protein autoubiquitination  negative regulation of nucleic acid-templated transcription  positive regulation of nucleic acid-templated transcription  
    REACTOMEQ13330 [protein]
    REACTOME PathwaysR-HSA-8943724 [pathway]   
    NDEx NetworkMTA1
    Atlas of Cancer Signalling NetworkMTA1
    Wikipedia pathwaysMTA1
    Orthology - Evolution
    OrthoDB9112
    GeneTree (enSembl)ENSG00000182979
    Phylogenetic Trees/Animal Genes : TreeFamMTA1
    HOVERGENQ13330
    HOGENOMQ13330
    Homologs : HomoloGeneMTA1
    Homology/Alignments : Family Browser (UCSC)MTA1
    Gene fusions - Rearrangements
    Fusion : MitelmanMTA1/PACS2 [14q32.33/14q32.33]  
    Fusion PortalMTA1 14q32.33 PACS2 14q32.33 BRCA HNSC LUSC
    Fusion : QuiverMTA1
    Polymorphisms : SNP and Copy number variants
    NCBI Variation ViewerMTA1 [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)MTA1
    dbVarMTA1
    ClinVarMTA1
    1000_GenomesMTA1 
    Exome Variant ServerMTA1
    ExAC (Exome Aggregation Consortium)ENSG00000182979
    GNOMAD BrowserENSG00000182979
    Varsome BrowserMTA1
    Genetic variants : HAPMAP9112
    Genomic Variants (DGV)MTA1 [DGVbeta]
    DECIPHERMTA1 [patients]   [syndromes]   [variants]   [genes]  
    CONAN: Copy Number AnalysisMTA1 
    Mutations
    ICGC Data PortalMTA1 
    TCGA Data PortalMTA1 
    Broad Tumor PortalMTA1
    OASIS PortalMTA1 [ Somatic mutations - Copy number]
    Somatic Mutations in Cancer : COSMICMTA1  [overview]  [genome browser]  [tissue]  [distribution]  
    Mutations and Diseases : HGMDMTA1
    LOVD (Leiden Open Variation Database)Whole genome datasets
    LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
    LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
    BioMutasearch MTA1
    DgiDB (Drug Gene Interaction Database)MTA1
    DoCM (Curated mutations)MTA1 (select the gene name)
    CIViC (Clinical Interpretations of Variants in Cancer)MTA1 (select a term)
    intoGenMTA1
    NCG5 (London)MTA1
    Cancer3DMTA1(select the gene name)
    Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
    Diseases
    OMIM603526   
    Orphanet
    DisGeNETMTA1
    MedgenMTA1
    Genetic Testing Registry MTA1
    NextProtQ13330 [Medical]
    TSGene9112
    GENETestsMTA1
    Target ValidationMTA1
    Huge Navigator MTA1 [HugePedia]
    snp3D : Map Gene to Disease9112
    BioCentury BCIQMTA1
    ClinGenMTA1
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD9112
    Chemical/Pharm GKB GenePA31218
    Clinical trialMTA1
    Miscellaneous
    canSAR (ICR)MTA1 (select the gene name)
    Probes
    Litterature
    PubMed234 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    CoreMineMTA1
    EVEXMTA1
    GoPubMedMTA1
    iHOPMTA1
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

    Search in all EBI   NCBI

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