MTA3 functions as a transcriptional repressor through interacting with histone deacetylases and nucleosome remodelling complexes such as Mi-2\/NuRD. Since MTA3 inhibits expression of SNAIL, a transcriptional repressor of the cell adhesion protein E-cadherin, downregulation of MTA3 was found to be associated with reduced E-cadherin levels and advanced cancer stages. Recent data also revealed upregulation of MTA3 in non-small lung cancer cells and highly aggressive subtypes of endometrial cancer, additionally indicating cancer-promoting effects of MTA3.
Ansgar Brüning ; Ioannis Mylonas
MTA3 (metastasis associated 1 family, member 3 )
Atlas Genet Cytogenet Oncol Haematol. 2014-06-01
Online version: http://atlasgeneticsoncology.org/gene/41445/mta3-(metastasis-associated-1-family-member-3-)
2010-11-01 MTA3 (metastasis associated 1 family, member 3 ) by Ansgar Brüning,Ioannis Mylonas