MTA1 (metastasis-associated gene 1)
2005-04-01 Yasushi Toh , Garth L Nicolson AffiliationDepartment of Gastroenterological Surgery National Kyushu Cancer, Center Fukuoka, 811-1395, Japan
DNA/RNA
Transcription
About 2.7 k mRNA; Protein coding region of 714 amino acid residues.
Proteins
Motifs in putative amino acid sequence of MTA1.
A leucine zipper motif and a GATA-type zinc finger motif are found near the mid-portion of the protein. Between them, a SANT domain is found which is homologous to the DNA binding domain of the myb oncogene family. In the amino terminal 200 amino acid residues, there are two highly acidic regions characteristic of the acidic activation domains of many transcription factors. At the carboxyl-terminus is a proline rich stretch whose sequence matches the consensus sequence of the src-homology 3-binding motif. Three putative nuclear localization signals are also present in the sequence.
Description
715 amino acids; about 80 kDa.
Expression
Found in almost all tissues; most abundantly expressed in testis.
Localisation
Nucleus.
Function
MTA1 protein physically interacts with histone deacetylase 1 and is included in a protein nucleosome remodeling complex, NuRD (nucleosome remodeling and histone deacetylation). This protein complex, containing histone deacetylase, plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control.
Implicated in
Disease
Cancer invasion and metastasis as follows:
Overexpression of MTA1 mRNA is correlated with the depth of invasion and lymph node metastasis in gastric and colorectal carcinomas as well as in esophageal carcinomas. The correlation of overexpression of this gene is also reported in lung cancer, thymoma and prostate cancer.
Overexpression of MTA1 protein might be a useful predictor for poor prognosis of human esophageal squamous cell carcinomas.
Forced expression of the MTA1 protein in breast cancer cell line MCF-7 is accompanied by enhancement of the ability of cells to invade an artificial matrix and to grow in an anchorage-independent manner.
Increasing MTA1 expression enhances migration, invasion and anchorage-independent survival of immortalized human keratinocytes.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11474200 | 2001 | Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization. | Cui Q et al |
| 12705869 | 2003 | MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. | Fujita N et al |
| 14871807 | 2004 | The role of metastasis-associated protein 1 in prostate cancer progression. | Hofer MD et al |
| 14613024 | 2003 | Emerging roles of MTA family members in human cancers. | Kumar R et al |
| 11948399 | 2002 | Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes. | Mahoney MG et al |
| 11146623 | 2001 | Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. | Mazumdar A et al |
| 10967548 | 2000 | Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. | Nawa A et al |
| 11804687 | 2002 | Expression of the MTA1 mRNA in advanced lung cancer. | Sasaki H et al |
| 11689291 | 2001 | Expression of the MTA1 mRNA in thymoma patients. | Sasaki H et al |
| 10840944 | 2000 | Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1. | Toh Y et al |
| 10206283 | 1999 | Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas. | Toh Y et al |
| 15095300 | 2004 | Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. | Toh Y et al |
| 9291440 | 1997 | Overexpression of the MTA1 gene in gastrointestinal carcinomas: correlation with invasion and metastasis. | Toh Y et al |
| 8083195 | 1994 | A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. | Toh Y et al |
| 9885572 | 1998 | NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. | Xue Y et al |
Other Information
Locus ID:
NCBI: 9112
MIM: 603526
HGNC: 7410
Ensembl: ENSG00000182979
Variants:
dbSNP: 9112
ClinVar: 9112
TCGA: ENSG00000182979
COSMIC: MTA1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36689059 | 2023 | MTA1 as negative prognostic marker in vulvar carcinoma. | 0 |
| 36689059 | 2023 | MTA1 as negative prognostic marker in vulvar carcinoma. | 0 |
| 32126261 | 2022 | Metastasis-associated protein 1-mediated antitumor and anticancer activity of dietary stilbenes for prostate cancer chemoprevention and therapy. | 12 |
| 35369814 | 2022 | Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity. | 4 |
| 35490918 | 2022 | RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma. | 7 |
| 35642705 | 2022 | miR-30 inhibits the progression of osteosarcoma by targeting MTA1. | 2 |
| 35792131 | 2022 | MTA1: A Vital Modulator in Prostate Cancer. | 1 |
| 35951452 | 2022 | Correlation between metastasis-associated gene 1 expression and tumor-associated macrophages in non-small cell lung cancer. | 1 |
| 36041657 | 2022 | RNAi Screen Identifies MTA1 as an Epigenetic Modifier of Differentiation Commitment in Human HSPCs. | 2 |
| 36164698 | 2022 | [The role and mechanism of tumor metastasis-associated gene 1 in radiosensitivity of HeLa cells]. | 0 |
| 36210748 | 2022 | Metastasis-associated protein 1: A potential driver and regulator of the hallmarks of cancer. | 0 |
| 32126261 | 2022 | Metastasis-associated protein 1-mediated antitumor and anticancer activity of dietary stilbenes for prostate cancer chemoprevention and therapy. | 12 |
| 35369814 | 2022 | Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity. | 4 |
| 35490918 | 2022 | RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma. | 7 |
| 35642705 | 2022 | miR-30 inhibits the progression of osteosarcoma by targeting MTA1. | 2 |
Citation
Yasushi Toh ; Garth L Nicolson
MTA1 (metastasis-associated gene 1)
Atlas Genet Cytogenet Oncol Haematol. 2005-04-01
Online version: http://atlasgeneticsoncology.org/gene/41443/mta1
