MXI1 (MAX interactor 1)
1999-12-01 Niels B Atkin AffiliationDepartment of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, UK
Identity
HGNC
LOCATION
10q25.2
LOCUSID
ALIAS
MAD2,MXD2,MXI,bHLHc11
FUSION GENES
DNA/RNA
Description
the gene spans approximately 60 kb; 6 exons
Transcription
2.6 kb mRNA; two transcription initiation sites
Proteins
Description
228 amino acids; 26 kDa; contains a basic region/helix-loop-helix/leucine zipper (B-HLH-LZ) motif that is similar to that found in Myc family
Expression
tissue specific; induced during cells terminal differentiation
Localisation
nuclear
Function
Mxil, discovered in 1993, is, with Mad, one of the proteins that can regulate Max, a human protein containing a basic helix-loop-helix leucine zipper (bHLH-zip) that allows the formation of cMyc-Max heterodimers and that activates transcription; Mad and Mxil may be involved in tumour suppression since they can compete with Myc proteins for the interaction with Max; Mxil normally functions to suppress cell growth: experimental induction of the gene resulted in the accumulation of cells in G2-M phase
Homology
belongs to the basic helix-loop-helix (bhlh) family of transcription factors
Mutations
Somatic
mutations have been described in some sporadic prostate cancers but no germline mutations were found in a study of 38 families with possible predisposition to this disease; a correlation between a polymorphic repeat in the 3 untranslated region in Mxil mRNA and regulation of its transcription and degradation has been suggested
Implicated in
Entity name
implicated in some sporadic cases of prostate cancer and glioblastoma as a tumour suppressor gene
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7789959 | 1995 | Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. | Albarosa R et al |
| 10497252 | 1999 | Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2. | Benson LQ et al |
| 7773287 | 1995 | Mutation of the MXI1 gene in prostate cancer. | Eagle LR et al |
| 9376279 | 1997 | No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters. The CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group. | Edwards SM et al |
| 10382539 | 1999 | Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network. | Foley KP et al |
| 8827088 | 1996 | Point mutations of the Mxil gene are rare in prostate cancers. | Kawamata N et al |
| 8608977 | 1996 | Microsatellite instability and deletion analysis of chromosome 10 in human prostate cancer. | Lacombe L et al |
| 9872993 | 1999 | Mxi1 is a repressor of the c-Myc promoter and reverses activation by USF. | Lee TC et al |
| 9819568 | 1998 | Repression by the Mad(Mxi1)-Sin3 complex. | Schreiber-Agus N et al |
| 8918230 | 1996 | Expression, regulation and polymorphism of the mxi1 genes. | Shimizu E et al |
| 9354456 | 1997 | MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells. | Wechsler DS et al |
| 8425219 | 1993 | Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. | Zervos AS et al |
Other Information
Locus ID:
NCBI: 4601
MIM: 600020
HGNC: 7534
Ensembl: ENSG00000119950
Variants:
dbSNP: 4601
ClinVar: 4601
TCGA: ENSG00000119950
COSMIC: MXI1
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35501353 | 2022 | Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis. | 2 |
| 35501353 | 2022 | Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis. | 2 |
| 32901121 | 2021 | UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance. | 36 |
| 32901121 | 2021 | UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance. | 36 |
| 29507620 | 2018 | S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. | 25 |
| 30118760 | 2018 | FOXO3a-dependent up-regulation of Mxi1-0 promotes hypoxia-induced apoptosis in endothelial cells. | 8 |
| 29507620 | 2018 | S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. | 25 |
| 30118760 | 2018 | FOXO3a-dependent up-regulation of Mxi1-0 promotes hypoxia-induced apoptosis in endothelial cells. | 8 |
| 28065785 | 2017 | A positive feedback loop between ROS and Mxi1-0 promotes hypoxia-induced VEGF expression in human hepatocellular carcinoma cells. | 10 |
| 28575053 | 2017 | Mxi1-0 regulates the growth of human umbilical vein endothelial cells through extracellular signal-regulated kinase 1/2 (ERK1/2) and interleukin-8 (IL-8)-dependent pathways. | 4 |
| 28065785 | 2017 | A positive feedback loop between ROS and Mxi1-0 promotes hypoxia-induced VEGF expression in human hepatocellular carcinoma cells. | 10 |
| 28575053 | 2017 | Mxi1-0 regulates the growth of human umbilical vein endothelial cells through extracellular signal-regulated kinase 1/2 (ERK1/2) and interleukin-8 (IL-8)-dependent pathways. | 4 |
| 24685915 | 2014 | MYC and MXI1 protein expression: potential prognostic significance in women with breast cancer in China. | 2 |
| 24685915 | 2014 | MYC and MXI1 protein expression: potential prognostic significance in women with breast cancer in China. | 2 |
| 23254855 | 2013 | miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1. | 69 |
Citation
Niels B Atkin
MXI1 (MAX interactor 1)
Atlas Genet Cytogenet Oncol Haematol. 1999-12-01
Online version: http://atlasgeneticsoncology.org/gene/209/mxi1
