Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MXI1 (MAX interactor 1)

Written1999-12Niels B Atkin
Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, UK

(Note : for Links provided by Atlas : click)

Identity

Other alias
LocusID (NCBI) 4601
Atlas_Id 209
Location 10q25.2  [Link to chromosome band 10q25]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM107B (10p13) / MXI1 (10q25.2)MPG (16p13.3) / MXI1 (10q25.2)MXI1 (10q25.2) / HIF1A (14q23.2)
MXI1 (10q25.2) / MXI1 (10q25.2)MXI1 (10q25.2) / PEPD (19q13.11)PMEL (12q13.2) / MXI1 (10q25.2)
WDR6 (3p21.31) / MXI1 (10q25.2)

DNA/RNA

Description the gene spans approximately 60 kb; 6 exons
Transcription 2.6 kb mRNA; two transcription initiation sites

Protein

Description 228 amino acids; 26 kDa; contains a basic region/helix-loop-helix/leucine zipper (B-HLH-LZ) motif that is similar to that found in Myc family
Expression tissue specific; induced during cells terminal differentiation
Localisation nuclear
Function Mxil, discovered in 1993, is, with Mad, one of the proteins that can regulate Max, a human protein containing a basic helix-loop-helix leucine zipper (bHLH-zip) that allows the formation of cMyc-Max heterodimers and that activates transcription; Mad and Mxil may be involved in tumour suppression since they can compete with Myc proteins for the interaction with Max; Mxil normally functions to suppress cell growth: experimental induction of the gene resulted in the accumulation of cells in G2-M phase
Homology belongs to the basic helix-loop-helix (bhlh) family of transcription factors

Mutations

Somatic mutations have been described in some sporadic prostate cancers but no germline mutations were found in a study of 38 families with possible predisposition to this disease; a correlation between a polymorphic repeat in the 3' untranslated region in Mxil mRNA and regulation of its transcription and degradation has been suggested

Implicated in

Note
  
Entity implicated in some sporadic cases of prostate cancer and glioblastoma as a tumour suppressor gene
  

Bibliography

Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas.
Albarosa R, DiDonato S, Finocchiaro G
Human genetics. 1995 ; 95 (6) : 709-711.
PMID 7789959
 
Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2.
Benson LQ, Coon MR, Krueger LM, Han GC, Sarnaik AA, Wechsler DS
The Journal of biological chemistry. 1999 ; 274 (40) : 28794-28802.
PMID 10497252
 
Mutation of the MXI1 gene in prostate cancer.
Eagle LR, Yin X, Brothman AR, Williams BJ, Atkin NB, Prochownik EV
Nature genetics. 1995 ; 9 (3) : 249-255.
PMID 7773287
 
No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters. The CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group.
Edwards SM, Dearnaley DP, Ardern-Jones A, Hamoudi RA, Easton DF, Ford D, Shearer R, Dowe A, Eeles RA
British journal of cancer. 1997 ; 76 (8) : 992-1000.
PMID 9376279
 
Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network.
Foley KP, Eisenman RN
Biochimica et biophysica acta. 1999 ; 1423 (3) : M37-M47.
PMID 10382539
 
Point mutations of the Mxil gene are rare in prostate cancers.
Kawamata N, Park D, Wilczynski S, Yokota J, Koeffler HP
The Prostate. 1996 ; 29 (3) : 191-193.
PMID 8827088
 
Microsatellite instability and deletion analysis of chromosome 10 in human prostate cancer.
Lacombe L, Orlow I, Reuter VE, Fair WR, Dalbagni G, Zhang ZF, Cordon-Cardo C
International journal of cancer. Journal international du cancer. 1996 ; 69 (2) : 110-113.
PMID 8608977
 
Mxi1 is a repressor of the c-Myc promoter and reverses activation by USF.
Lee TC, Ziff EB
The Journal of biological chemistry. 1999 ; 274 (2) : 595-606.
PMID 9872993
 
Repression by the Mad(Mxi1)-Sin3 complex.
Schreiber-Agus N, DePinho RA
BioEssays : news and reviews in molecular, cellular and developmental biology. 1998 ; 20 (10) : 808-818.
PMID 9819568
 
Expression, regulation and polymorphism of the mxi1 genes.
Shimizu E, Shirasawa H, Kodama K, Sato T, Simizu B
Gene. 1996 ; 176 (1-2) : 45-48.
PMID 8918230
 
MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells.
Wechsler DS, Shelly CA, Petroff CA, Dang CV
Cancer research. 1997 ; 57 (21) : 4905-4912.
PMID 9354456
 
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites.
Zervos AS, Gyuris J, Brent R
Cell. 1993 ; 72 (2) : 223-232.
PMID 8425219
 

Citation

This paper should be referenced as such :
Atkin, NB
MXI1 (MAX interactor 1)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(4):185-186.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/MXI1ID209.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Nervous system: Astrocytic tumors


External links

Nomenclature
Cards
AtlasMXI1ID209.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4601
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Oct 18 17:44:32 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.