Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MYBL2 (v-myb myeloblastosis viral oncogene homolog (avian)-like 2)

Written2008-10Olesya Chayka, Arturo Sala
Institute of Child Health Molecular Haematology, Cancer Biology Unit 30 Guilford street London, WC1N 1EH UK

(Note : for Links provided by Atlas : click)


Alias_namesv-myb avian myeloblastosis viral oncogene homolog-like 2
Alias_symbol (synonym)BMYB
Other aliasB-Myb
LocusID (NCBI) 4605
Atlas_Id 41469
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 42295659 and ends at 42345136 bp from pter ( according to hg19-Feb_2009)  [Mapping MYBL2.png]
Fusion genes
(updated 2016)
ASRGL1 (11q12.3) / MYBL2 (20q13.12)MYBL2 (20q13.12) / MYBL2 (20q13.12)


  red boxes: untranslated regions; green boxes: coding regions.
Description 49,415 bases DNA with 14 exons.
Transcription 2,731 bases mRNA.


  R1, R2 and R3 form DNA-binding domain, TA - transactivation domain, CR - conserved region (the area of homology with c-Myb), RD - regulatory domain.
Description 704 amino acids, 93kDa protein.
R1, R2, R3 - three repeats 50 amino acids long, R2 and R3 contain HTH (helix-turn-helix) motives with unconventional turns required for DNA-binding activity, R1 serves as a DNA/protein complex stabilizer; TA contains acidic amino acids and is responsible for transcriptional activation; RD is responsible for repression of transactivation function of B-MYB.
Expression Widely expressed, expression is very high in proliferative cells, embryonic cells, haematopoietic progenitor cells.
Localisation Nucleus.
Function Transcription factor required for cell proliferation, cell cycle progression, chromosomal stability and differentiation. B-MYB knockout mice die at E4.5-E6.5 due to early developmental arrest.
Homology B-MYB is a member of MYB transcription factors family, which includes C-MYB and A-MYB, with high homology within TA and RD regions. DNA-binding domain is almost identical with that of A-MYB and C-MYB and conserved between mouse, human, chicken and drosophila.

Implicated in

Entity Neuroblastoma
Prognosis Overexpression is thought to be associated with a poor outcome of the disease.
Oncogenesis Was reported to be necessary for survival and differentiation of neuroblastoma cells.
Entity Hepatocellular carcinoma (HCC)
Oncogenesis B-MYB is reported to be a probable target of E2F1 transcription factor, which is dramatically overexpressed in HCC. There is a clear correlation between expression level of these two proteins. B-MYB overexpression in HCC causes the deregulation of apoptosis and cell cycle.
Entity Various cancer
Disease Amplification of B-MYB was described in breast carcinomas, liver carcinomas, ovarian carcinomas and in cutaneous T lymphoma. B-MYB expression was shown also to be increased in prostate and testicular malignancies. Moreover, B-MYB expression is notably increased in metastatic compared to localised prostate tumours.
The presence of B-MYB polymorphisms rs2070235 and rs11556379 is associated with a significant reduction of cancer risk.
Oncogenesis B-MYB overexpression may result in promotion of cancer cells survival and proliferation.
Polimorphisms can induce changes in protein conformation and therefore may in part deactivate B-MYB functions.


Activation of B-Myb by E2F1 in hepatocellular carcinoma.
Nakajima T, Yasui K, Zen K, Inagaki Y, Fujii H, Minami M, Tanaka S, Taniwaki M, Itoh Y, Arii S, Inazawa J, Okanoue T.
Hepatol Res. 2008; 38(9): 886-95.
PMID 18624722
Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q13.1.
Noben-Trauth K, Copeland NG, Gilbert DJ, Jenkins NA, Sonoda G, Testa JR, Klempnauer KH.
Genomics. 1996 Aug 1;35(3):610-2.
PMID 8812502
The myb gene family in cell growth, differentiation and apoptosis.
Oh IH, Reddy EP.
Oncogene. 1999 May 13;18(19):3017-33.(Review).
PMID 10378697
Requirement of b-myb function for survival and differentiative potential of human neuroblastoma cells.
Raschell G, Negroni A, Sala A, Pucci S, Romeo A, Calabretta B.
J Biol Chem. 1995 Apr 14;270(15):8540-5.
PMID 7721753
Expression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification.
Raschella G, Cesi V, Amendola R, Negroni A, Tanno B, Altavista P, Tonni GP, De Bernardi B, Calabretta B.
Cancer Res. 1999 Jul 15;59(14):3365-8.
PMID 10416595
B-Myb protein in cellular proliferation, transcription control, and cancer: latest developments.
Sala A, Watson R.
J Cell Physiol. 1999 Jun;179(3):245-50.(Review).
PMID 10228942
Isolation and functional assessment of common, polymorphic variants of the B-MYB proto-oncogene associated with a reduced cancer risk.
Schwab R, Bussolari R, Corvetta D, Chayka O, Santilli G, Kwok JM-M, Amorotti GF, Tonini P, Iacoviello L, Bertorelle R, Menin C, Hubank M, Calabretta B, Sala A.
Oncogene 2008; 27(20): 2929-33.
PMID 18026132
B-MYB is hypophosphorylated and resistant to degradation in neuroblastoma: implications for cell survival.
Schwab R, Caccamo A, Bettuzzi S, Anderson J, Sala A.
Blood Cells Mol Dis 2007; 39(3):263-71. Epub 2007 Jun 27.
PMID 17588787
B-myb is required for inner cell mass formation at an early stage of development.
Tanaka Y, Patestos NP, Maekawa T, Ishii S.
J Biol Chem. 1999 Oct 1;274(40):28067-70.
PMID 10497154


This paper should be referenced as such :
Chayka, O ; Sala, A
MYBL2 (v-myb myeloblastosis viral oncogene homolog (avian)-like 2)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(9):652-653.
Free journal version : [ pdf ]   [ DOI ]
On line version :

External links

HGNC (Hugo)MYBL2   7548
Entrez_Gene (NCBI)MYBL2  4605  MYB proto-oncogene like 2
AliasesB-MYB; BMYB
GeneCards (Weizmann)MYBL2
Ensembl hg19 (Hinxton)ENSG00000101057 [Gene_View]  chr20:42295659-42345136 [Contig_View]  MYBL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000101057 [Gene_View]  chr20:42295659-42345136 [Contig_View]  MYBL2 [Vega]
ICGC DataPortalENSG00000101057
TCGA cBioPortalMYBL2
Genatlas (Paris)MYBL2
SOURCE (Princeton)MYBL2
Genetics Home Reference (NIH)MYBL2
Genomic and cartography
GoldenPath hg19 (UCSC)MYBL2  -     chr20:42295659-42345136 +  20q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MYBL2  -     20q13.1   [Description]    (hg38-Dec_2013)
EnsemblMYBL2 - 20q13.1 [CytoView hg19]  MYBL2 - 20q13.1 [CytoView hg38]
Mapping of homologs : NCBIMYBL2 [Mapview hg19]  MYBL2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA586734 AK223482 AK303249 AK314791 BC007585
RefSeq transcript (Entrez)NM_001278610 NM_002466
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)MYBL2
Cluster EST : UnigeneHs.179718 [ NCBI ]
CGAP (NCI)Hs.179718
Alternative Splicing GalleryENSG00000101057
Gene ExpressionMYBL2 [ NCBI-GEO ]   MYBL2 [ EBI - ARRAY_EXPRESS ]   MYBL2 [ SEEK ]   MYBL2 [ MEM ]
Gene Expression Viewer (FireBrowse)MYBL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4605
GTEX Portal (Tissue expression)MYBL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10244   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10244  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10244
Splice isoforms : SwissVarP10244
Domaine pattern : Prosite (Expaxy)HTH_MYB (PS51294)   
Domains : Interpro (EBI)C-myb_C    Homeodomain-like    Myb_dom    MYBL2    SANT/Myb   
Domain families : Pfam (Sanger)Cmyb_C (PF09316)    Myb_DNA-binding (PF00249)   
Domain families : Pfam (NCBI)pfam09316    pfam00249   
Domain families : Smart (EMBL)SANT (SM00717)  
Conserved Domain (NCBI)MYBL2
DMDM Disease mutations4605
Blocks (Seattle)MYBL2
Human Protein AtlasENSG00000101057
Peptide AtlasP10244
IPIIPI00019993   IPI01015657   
Protein Interaction databases
IntAct (EBI)P10244
Ontologies - Pathways
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  transcription from RNA polymerase II promoter  Myb complex  positive regulation of transcription from RNA polymerase II promoter  regulation of cell cycle  mitotic spindle assembly  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  transcription from RNA polymerase II promoter  Myb complex  positive regulation of transcription from RNA polymerase II promoter  regulation of cell cycle  mitotic spindle assembly  
Pathways : KEGGHTLV-I infection   
REACTOMEP10244 [protein]
REACTOME Pathways1538133 [pathway]   156711 [pathway]   8869496 [pathway]   
NDEx NetworkMYBL2
Atlas of Cancer Signalling NetworkMYBL2
Wikipedia pathwaysMYBL2
Orthology - Evolution
GeneTree (enSembl)ENSG00000101057
Phylogenetic Trees/Animal Genes : TreeFamMYBL2
Homologs : HomoloGeneMYBL2
Homology/Alignments : Family Browser (UCSC)MYBL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYBL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYBL2
Exome Variant ServerMYBL2
ExAC (Exome Aggregation Consortium)MYBL2 (select the gene name)
Genetic variants : HAPMAP4605
Genomic Variants (DGV)MYBL2 [DGVbeta]
DECIPHER (Syndromes)20:42295659-42345136  ENSG00000101057
CONAN: Copy Number AnalysisMYBL2 
ICGC Data PortalMYBL2 
TCGA Data PortalMYBL2 
Broad Tumor PortalMYBL2
OASIS PortalMYBL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYBL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYBL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYBL2
DgiDB (Drug Gene Interaction Database)MYBL2
DoCM (Curated mutations)MYBL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYBL2 (select a term)
NCG5 (London)MYBL2
Cancer3DMYBL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry MYBL2
NextProtP10244 [Medical]
Huge Navigator MYBL2 [HugePedia]
snp3D : Map Gene to Disease4605
BioCentury BCIQMYBL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4605
Chemical/Pharm GKB GenePA31348
Clinical trialMYBL2
canSAR (ICR)MYBL2 (select the gene name)
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Apr 12 11:35:56 CEST 2017

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