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| | R1, R2 and R3 form DNA-binding domain, TA - transactivation domain, CR - conserved region (the area of homology with c-Myb), RD - regulatory domain. |
| |
| Description | 704 amino acids, 93kDa protein.
R1, R2, R3 - three repeats 50 amino acids long, R2 and R3 contain HTH (helix-turn-helix) motives with unconventional turns required for DNA-binding activity, R1 serves as a DNA/protein complex stabilizer; TA contains acidic amino acids and is responsible for transcriptional activation; RD is responsible for repression of transactivation function of B-MYB. |
| Expression | Widely expressed, expression is very high in proliferative cells, embryonic cells, haematopoietic progenitor cells. |
| Localisation | Nucleus. |
| Function | Transcription factor required for cell proliferation, cell cycle progression, chromosomal stability and differentiation. B-MYB knockout mice die at E4.5-E6.5 due to early developmental arrest. |
| Homology | B-MYB is a member of MYB transcription factors family, which includes C-MYB and A-MYB, with high homology within TA and RD regions. DNA-binding domain is almost identical with that of A-MYB and C-MYB and conserved between mouse, human, chicken and drosophila. |
| Activation of B-Myb by E2F1 in hepatocellular carcinoma. |
| Nakajima T, Yasui K, Zen K, Inagaki Y, Fujii H, Minami M, Tanaka S, Taniwaki M, Itoh Y, Arii S, Inazawa J, Okanoue T. |
| Hepatol Res. 2008; 38(9): 886-95. |
| PMID 18624722 |
| |
| Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q13.1. |
| Noben-Trauth K, Copeland NG, Gilbert DJ, Jenkins NA, Sonoda G, Testa JR, Klempnauer KH. |
| Genomics. 1996 Aug 1;35(3):610-2. |
| PMID 8812502 |
| |
| The myb gene family in cell growth, differentiation and apoptosis. |
| Oh IH, Reddy EP. |
| Oncogene. 1999 May 13;18(19):3017-33.(Review). |
| PMID 10378697 |
| |
| Requirement of b-myb function for survival and differentiative potential of human neuroblastoma cells. |
| Raschell G, Negroni A, Sala A, Pucci S, Romeo A, Calabretta B. |
| J Biol Chem. 1995 Apr 14;270(15):8540-5. |
| PMID 7721753 |
| |
| Expression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification. |
| Raschella G, Cesi V, Amendola R, Negroni A, Tanno B, Altavista P, Tonni GP, De Bernardi B, Calabretta B. |
| Cancer Res. 1999 Jul 15;59(14):3365-8. |
| PMID 10416595 |
| |
| B-Myb protein in cellular proliferation, transcription control, and cancer: latest developments. |
| Sala A, Watson R. |
| J Cell Physiol. 1999 Jun;179(3):245-50.(Review). |
| PMID 10228942 |
| |
| Isolation and functional assessment of common, polymorphic variants of the B-MYB proto-oncogene associated with a reduced cancer risk. |
| Schwab R, Bussolari R, Corvetta D, Chayka O, Santilli G, Kwok JM-M, Amorotti GF, Tonini P, Iacoviello L, Bertorelle R, Menin C, Hubank M, Calabretta B, Sala A. |
| Oncogene 2008; 27(20): 2929-33. |
| PMID 18026132 |
| |
| B-MYB is hypophosphorylated and resistant to degradation in neuroblastoma: implications for cell survival. |
| Schwab R, Caccamo A, Bettuzzi S, Anderson J, Sala A. |
| Blood Cells Mol Dis 2007; 39(3):263-71. Epub 2007 Jun 27. |
| PMID 17588787 |
| |
| B-myb is required for inner cell mass formation at an early stage of development. |
| Tanaka Y, Patestos NP, Maekawa T, Ishii S. |
| J Biol Chem. 1999 Oct 1;274(40):28067-70. |
| PMID 10497154 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | MYBL2 7548 |
| Cards |
|---|
| Atlas | MYBL2ID41469ch20q13 |
| Entrez_Gene (NCBI) | MYBL2 4605 MYB proto-oncogene like 2 |
| Aliases | B-MYB; BMYB |
| GeneCards (Weizmann) | MYBL2 |
| Ensembl hg19 (Hinxton) | ENSG00000101057 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000101057 [Gene_View] chr20:43667019-43716496 [Contig_View] MYBL2 [Vega] |
| ICGC DataPortal | ENSG00000101057 |
| TCGA cBioPortal | MYBL2 |
| AceView (NCBI) | MYBL2 |
| Genatlas (Paris) | MYBL2 |
| WikiGenes | 4605 |
| SOURCE (Princeton) | MYBL2 |
| Genetics Home Reference (NIH) | MYBL2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MYBL2 - chr20:43667019-43716496 + 20q13.12 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MYBL2 - 20q13.12 [Description] (hg19-Feb_2009) |
| Ensembl | MYBL2 - 20q13.12 [CytoView hg19] MYBL2 - 20q13.12 [CytoView hg38] |
| Mapping of homologs : NCBI | MYBL2 [Mapview hg19] MYBL2 [Mapview hg38] |
| OMIM | 601415 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA586734 AK223482 AK303249 AK314791 BC007585 |
| RefSeq transcript (Entrez) | NM_001278610 NM_002466 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | MYBL2 |
| Cluster EST : Unigene | Hs.179718 [ NCBI ] |
| CGAP (NCI) | Hs.179718 |
| Alternative Splicing Gallery | ENSG00000101057 |
| Gene Expression | MYBL2 [ NCBI-GEO ] MYBL2 [ EBI - ARRAY_EXPRESS ]
MYBL2 [ SEEK ] MYBL2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MYBL2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4605 |
| GTEX Portal (Tissue expression) | MYBL2 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P10244 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P10244 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P10244 |
| Splice isoforms : SwissVar | P10244 |
| PhosPhoSitePlus | P10244 |
| Domaine pattern : Prosite (Expaxy) | HTH_MYB (PS51294) |
| Domains : Interpro (EBI) | C-myb_C Homeobox-like Myb_dom SANT/Myb |
| Domain families : Pfam (Sanger) | Cmyb_C (PF09316) Myb_DNA-binding (PF00249) |
| Domain families : Pfam (NCBI) | pfam09316 pfam00249 |
| Domain families : Smart (EMBL) | SANT (SM00717) |
| Conserved Domain (NCBI) | MYBL2 |
| DMDM Disease mutations | 4605 |
| Blocks (Seattle) | MYBL2 |
| Superfamily | P10244 |
| Human Protein Atlas | ENSG00000101057 |
| Peptide Atlas | P10244 |
| HPRD | 03247 |
| IPI | IPI00019993 IPI01015657 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P10244 |
| IntAct (EBI) | P10244 |
| FunCoup | ENSG00000101057 |
| BioGRID | MYBL2 |
| STRING (EMBL) | MYBL2 |
| ZODIAC | MYBL2 |
| Ontologies - Pathways |
|---|
| QuickGO | P10244 |
| Ontology : AmiGO | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, RNA polymerase II transcription factor recruiting transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nucleoplasm regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell differentiation Myb complex positive regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter regulation of cell cycle mitotic spindle assembly |
| Ontology : EGO-EBI | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, RNA polymerase II transcription factor recruiting transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nucleoplasm regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell differentiation Myb complex positive regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter regulation of cell cycle mitotic spindle assembly |
| Pathways : KEGG | HTLV-I infection |
| REACTOME | P10244 [protein] |
| REACTOME Pathways | R-HSA-8869496 [pathway] |
| NDEx Network | MYBL2 |
| Atlas of Cancer Signalling Network | MYBL2 |
| Wikipedia pathways | MYBL2 |
| Orthology - Evolution |
|---|
| OrthoDB | 4605 |
| GeneTree (enSembl) | ENSG00000101057 |
| Phylogenetic Trees/Animal Genes : TreeFam | MYBL2 |
| HOVERGEN | P10244 |
| HOGENOM | P10244 |
| Homologs : HomoloGene | MYBL2 |
| Homology/Alignments : Family Browser (UCSC) | MYBL2 |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MYBL2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MYBL2 |
| dbVar | MYBL2 |
| ClinVar | MYBL2 |
| 1000_Genomes | MYBL2 |
| Exome Variant Server | MYBL2 |
| ExAC (Exome Aggregation Consortium) | MYBL2 (select the gene name) |
| Genetic variants : HAPMAP | 4605 |
| Genomic Variants (DGV) | MYBL2 [DGVbeta] |
| DECIPHER | MYBL2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MYBL2 |
| Mutations |
|---|
| ICGC Data Portal | MYBL2 |
| TCGA Data Portal | MYBL2 |
| Broad Tumor Portal | MYBL2 |
| OASIS Portal | MYBL2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | MYBL2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | MYBL2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search MYBL2 |
| DgiDB (Drug Gene Interaction Database) | MYBL2 |
| DoCM (Curated mutations) | MYBL2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MYBL2 (select a term) |
| intoGen | MYBL2 |
| NCG5 (London) | MYBL2 |
| Cancer3D | MYBL2(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 601415 |
| Orphanet | |
| Medgen | MYBL2 |
| Genetic Testing Registry | MYBL2
|
| NextProt | P10244 [Medical] |
| TSGene | 4605 |
| GENETests | MYBL2 |
| Target Validation | MYBL2 |
| Huge Navigator |
MYBL2 [HugePedia] |
| snp3D : Map Gene to Disease | 4605 |
| BioCentury BCIQ | MYBL2 |
| ClinGen | MYBL2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 4605 |
| Chemical/Pharm GKB Gene | PA31348 |
| Clinical trial | MYBL2 |
| Miscellaneous |
|---|
| canSAR (ICR) | MYBL2 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 93 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | MYBL2 |
| EVEX | MYBL2 |
| GoPubMed | MYBL2 |
| iHOP | MYBL2 |
