MYBL2 (v-myb myeloblastosis viral oncogene homolog (avian)-like 2)
2008-10-01 Olesya Chayka , Arturo Sala AffiliationInstitute of Child Health Molecular Haematology, Cancer Biology Unit 30 Guilford street London, WC1N 1EH UK
DNA/RNA
red boxes: untranslated regions; green boxes: coding regions.
Description
49,415 bases DNA with 14 exons.
Transcription
2,731 bases mRNA.
Proteins
R1, R2 and R3 form DNA-binding domain, TA - transactivation domain, CR - conserved region (the area of homology with c-Myb), RD - regulatory domain.
Description
704 amino acids, 93kDa protein.
R1, R2, R3 - three repeats 50 amino acids long, R2 and R3 contain HTH (helix-turn-helix) motives with unconventional turns required for DNA-binding activity, R1 serves as a DNA/protein complex stabilizer; TA contains acidic amino acids and is responsible for transcriptional activation; RD is responsible for repression of transactivation function of B-MYB.
R1, R2, R3 - three repeats 50 amino acids long, R2 and R3 contain HTH (helix-turn-helix) motives with unconventional turns required for DNA-binding activity, R1 serves as a DNA/protein complex stabilizer; TA contains acidic amino acids and is responsible for transcriptional activation; RD is responsible for repression of transactivation function of B-MYB.
Expression
Widely expressed, expression is very high in proliferative cells, embryonic cells, haematopoietic progenitor cells.
Localisation
Nucleus.
Function
Transcription factor required for cell proliferation, cell cycle progression, chromosomal stability and differentiation. B-MYB knockout mice die at E4.5-E6.5 due to early developmental arrest.
Implicated in
Entity name
Neuroblastoma
Prognosis
Overexpression is thought to be associated with a poor outcome of the disease.
Oncogenesis
Was reported to be necessary for survival and differentiation of neuroblastoma cells.
Entity name
Hepatocellular carcinoma (HCC)
Oncogenesis
B-MYB is reported to be a probable target of E2F1 transcription factor, which is dramatically overexpressed in HCC. There is a clear correlation between expression level of these two proteins. B-MYB overexpression in HCC causes the deregulation of apoptosis and cell cycle.
Entity name
Various cancer
Disease
Amplification of B-MYB was described in breast carcinomas, liver carcinomas, ovarian carcinomas and in cutaneous T lymphoma. B-MYB expression was shown also to be increased in prostate and testicular malignancies. Moreover, B-MYB expression is notably increased in metastatic compared to localised prostate tumours.
The presence of B-MYB polymorphisms rs2070235 and rs11556379 is associated with a significant reduction of cancer risk.
The presence of B-MYB polymorphisms rs2070235 and rs11556379 is associated with a significant reduction of cancer risk.
Oncogenesis
B-MYB overexpression may result in promotion of cancer cells survival and proliferation.
Polimorphisms can induce changes in protein conformation and therefore may in part deactivate B-MYB functions.
Polimorphisms can induce changes in protein conformation and therefore may in part deactivate B-MYB functions.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 18624722 | 2008 | Activation of B-Myb by E2F1 in hepatocellular carcinoma. | Nakajima T et al |
| 8812502 | 1996 | Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. | Noben-Trauth K et al |
| 10378697 | 1999 | The myb gene family in cell growth, differentiation and apoptosis. | Oh IH et al |
| 7721753 | 1995 | Requirement of b-myb function for survival and differentiative potential of human neuroblastoma cells. | Raschellà G et al |
| 10416595 | 1999 | Expression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification. | Raschellà G et al |
| 10228942 | 1999 | B-Myb protein in cellular proliferation, transcription control, and cancer: latest developments. | Sala A et al |
| 18026132 | 2008 | Isolation and functional assessment of common, polymorphic variants of the B-MYB proto-oncogene associated with a reduced cancer risk. | Schwab R et al |
| 17588787 | 2007 | B-MYB is hypophosphorylated and resistant to degradation in neuroblastoma: implications for cell survival. | Schwab R et al |
| 10497154 | 1999 | B-myb is required for inner cell mass formation at an early stage of development. | Tanaka Y et al |
Other Information
Locus ID:
NCBI: 4605
MIM: 601415
HGNC: 7548
Ensembl: ENSG00000101057
Variants:
dbSNP: 4605
ClinVar: 4605
TCGA: ENSG00000101057
COSMIC: MYBL2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000101057 | ENST00000217026 | P10244 |
| ENSG00000101057 | ENST00000396863 | P10244 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38182898 | 2024 | Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers. | 0 |
| 38336287 | 2024 | Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation. | 0 |
| 38182898 | 2024 | Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers. | 0 |
| 38336287 | 2024 | Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation. | 0 |
| 36812959 | 2023 | Transcription factor B-MYB activates lncRNA CCAT1 and upregulates SOCS3 to promote chemoresistance in colorectal cancer. | 6 |
| 36854682 | 2023 | Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer. | 3 |
| 37030434 | 2023 | Up-regulation of ABCG2 by MYBL2 deletion drives Chlorin e6-mediated photodynamic therapy resistance in colorectal cancer. | 3 |
| 36812959 | 2023 | Transcription factor B-MYB activates lncRNA CCAT1 and upregulates SOCS3 to promote chemoresistance in colorectal cancer. | 6 |
| 36854682 | 2023 | Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer. | 3 |
| 37030434 | 2023 | Up-regulation of ABCG2 by MYBL2 deletion drives Chlorin e6-mediated photodynamic therapy resistance in colorectal cancer. | 3 |
| 35135230 | 2022 | Elevated expression of the MYB proto-oncogene like 2 (MYBL2)-encoding gene as a prognostic and predictive biomarker in human cancers. | 7 |
| 35176941 | 2022 | MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression. | 4 |
| 35341461 | 2022 | Actin-binding Rho activating C-terminal like (ABRACL) transcriptionally regulated by MYB proto-oncogene like 2 (MYBL2) promotes the proliferation, invasion, migration and epithelial-mesenchymal transition of breast cancer cells. | 3 |
| 35557985 | 2022 | LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis. | 8 |
| 36071275 | 2022 | MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3. | 12 |
Citation
Olesya Chayka ; Arturo Sala
MYBL2 (v-myb myeloblastosis viral oncogene homolog (avian)-like 2)
Atlas Genet Cytogenet Oncol Haematol. 2008-10-01
Online version: http://atlasgeneticsoncology.org/gene/41469/mybl2
