| Identity |
| Other names | OCIM |
| HGNC (Hugo) | MYEOV |
| Location | 11q13 |
| Location_base_pair | Starts at 69061622 and ends at 69064753 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| Local_order | 350 kb centromeric of cyclin D1 |
| Note | detected by application of the NIH/3T3 tumorigenicity assay. However MYEOV cDNA was not positive in NIH/3T3 assay. |
| DNA/RNA |
| Description | 2 exons; 3.5 kb transcript represents unspliced mRNA. |
| Transcription | main transcript 2.8 kb (broad band because of alternative splice products); minor transcript 3.5 kb.; coding sequence 313 or 255 amino acids. In normal tissues hardly any expression detectable. High expression in a subset of multiple myeloma cell lines with a t(11;14)(q13;q32) and in breast tumors and esophageal squamous cell carcinomas with or without 11q13 amplification. |
| Protein |
| Description | 313 or 255 amino acids; contains one RNP-1 motif and 6 regions that might function as a transmembrane domain. Leucine-rich stretch at C-terminal. |
| Expression | 5Ô UTR inhibits efficient translation of the protein |
| Localisation | in endoplasmic reticulum and mitochondria. |
| Implicated in |
| Entity | t(11;14)(q13;q32) |
| Disease | subset of multiple myeloma cell lines with t(11;14)(q13;q32) |
| Cytogenetics | myeov overexpression due to juxtaposition to the 5' enhancer or the most telomeric 3' enhancer of the immunoglobulin heavy chain (IgH). |
| Entity | 11q13 amplification and/or overexpression |
| Disease | breast cancer; esophageal squamous cell carcinomas. |
| Prognosis | MYEOV DNA amplification correlated with estrogen and progesterone receptor-positive cancer, invasive lobular carcinoma type and axillary nodal involvement. In contrast to Cyclin D1 amplification, no association with disease outcome could be found. |
| External links |
| Nomenclature | |
|---|---|
| HGNC (Hugo) | MYEOV 7563 |
| Entrez_Gene (NCBI) | MYEOV 26579 myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas) |
| Cards | |
| Atlas | MYEOVID395 |
| GeneCards (Weizmann) | MYEOV |
| Ensembl (Hinxton) | ENSG00000172927 [Gene_View] MYEOV [Vega] |
| AceView (NCBI) | MYEOV |
| Genatlas (Paris) | MYEOV |
| euGene (Indiana) | 26579 |
| SOURCE (Stanford) | NM_138768 |
| Gene Expression (Array Express) | ENSG00000172927 |
| Genomic and cartography | |
| GoldenPath (UCSC) | MYEOV - 11q13 chr11:69061622-69064753 + 11q13 [Description] (hg19-Feb_2009) |
| Ensembl | MYEOV - 11q13 [CytoView] |
| Mapping of homologs : NCBI | MYEOV [Mapview] |
| OMIM | 605625 |
| Gene and transcription | |
| Gene : Genbank (Entrez) | AJ223366 AJ223366 AK026148 AK290121 BC011815 |
| Reference sequence (RefSeq transcript) :SRS | NM_138768 |
| Reference transcript : Entrez | NM_138768 |
| RefSeq genomic : SRS | AC_000054 AC_000143 NC_000011 NT_167190 NW_001838026 NW_925106 |
| RefSeq genomic : Entrez | AC_000054 AC_000143 NC_000011 NT_167190 NW_001838026 NW_925106 |
| Consensus coding sequences : CCDS NCBI | MYEOV |
| Cluster EST : Unigene | Hs.523848 [ SRS ] Hs.523848 [ NCBI ] |
| Alternative Splicing : Fast-db (Paris) | 11061 |
| Protein : pattern, domain, 3D structure | |
| Protein : UniProt/SwissProt | Q96EZ4 (SRS) Q96EZ4 (Expasy) Q96EZ4 (Uniprot) |
| With graphics : InterPro | Q96EZ4 |
| Splice isoforms : VarSplice FASTA | Q96EZ4(VarSplice FASTA) |
| Related proteins : CluSTr | Q96EZ4 |
| Domain families : Pfam SRS | |
| Domain families : Pfam Sanger | |
| Domain families : Pfam NCBI | |
| Blocks (Seattle) | Q96EZ4 |
| Crystal structure of protein : PDB SRS | |
| Crystal structure of protein : PDBSum | |
| Crystal structure of protein : IMB | |
| Crystal structure of protein : PDB RSDB | |
| Human Protein Atlas | ENSG00000172927 |
| HPRD | 16130 |
| Protein Interaction databases | |
| DIP (DOE-UCLA) | Q96EZ4 |
| IntAct (EBI) | Q96EZ4 |
| FunCoup | ENSG00000172927 |
| Polymorphism : SNP, mutations, diseases | |
| Single Nucleotide Polymorphism (SNP) : dbSNP NCBI | MYEOV |
| SNP : GeneSNP Utah | MYEOV |
| SNP : HGBase | MYEOV |
| Genetic variants : HAPMAP | MYEOV |
| Somatic Mutations in Cancer : COSMIC | MYEOV |
| Mutations and Diseases : HGMD | MYEOV |
| Hereditary diseases : OMIM | 605625 |
| Hereditary diseases : GENETests | 605625 |
| Diseases : Genetic Association | MYEOV |
| General knowledge | |
| Homologs : HomoloGene | MYEOV |
| Homology/Alignments : Family Browser UCSC | MYEOV |
| Phylogenetic Trees/Animal Genes : TreeFam | MYEOV |
| Chemical/Protein Interactions : CTD | 26579 |
| Keywords Ontology : AmiGO | |
| Keywords Ontology : EGO-EBI | |
| Pathways : BIOCARTA | |
| Pathways : KEGG | |
| Other databases | |
| Probes | |
| Probes : Imagenes | MYEOV Related clones (RZPD - Berlin) |
| Literature | |
| PubMed | 12 Pubmed reference(s) in Entrez |
| PubGene | MYEOV |
| Bibliography |
| Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32). |
| Janssen JW, Vaandrager JW, Heuser T, Jauch A, Kluin PM, Geelen E, Bergsagel PL, Kuehl WM, Drexler HG, Otsuki T, Bartram CR, Schuuring E |
| Blood. 2000 ; 95 (8) : 2691-2698. |
| PMID 10753852 |
| MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas. |
| Janssen JW, Imoto I, Inoue J, Shimada Y, Ueda M, Imamura M, Bartram CR, Inazawa J |
| Journal of human genetics. 2002 ; 47 (9) : 460-464. |
| PMID 12202983 |
| MYEOV: a candidate gene for DNA amplification events occurring centromeric to CCND1 in breast cancer. |
| Janssen JW, Cuny M, Orsetti B, Rodriguez C, Vallˆ©s H, Bartram CR, Schuuring E, Theillet C |
| International journal of cancer. Journal international du cancer. 2002 ; 102 (6) : 608-614. |
| PMID 12448002 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 12-2002 | Johannes W.G. Janssen |
| Janssen Institut für Humangenetik Universitätsklinikum Heidelberg Im Neuenheimer Feld 328 D-69120 Heidelberg, Germany |
| Citation |
| This paper should be referenced as such : |
| Janssen JWG . MYEOV myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas). Atlas Genet Cytogenet Oncol Haematol. December 2002 . URL : http://AtlasGeneticsOncology.org/Genes/MYEOVID395.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Jul 15 14:43:27 CEST 2010 |
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