| CGNL1 (15q21.3) / TCF12 (15q21.3) | FMNL2 (2q23.3) / TCF12 (15q21.3) | KMT2A (11q23.3) / TCF12 (15q21.3) |
|
MAP3K5 (6q23.3) / TCF12 (15q21.3) | MIR548H3 (6q16.1) / TCF12 (15q21.3) | NR4A3 (9q22.33) / TCF12 (15q21.3) |
|
OSCP1 (1p34.3) / TCF12 (15q21.3) | RNF111 (15q22.1) / TCF12 (15q21.3) | RREB1 (6p24.3) / TCF12 (15q21.3) |
|
RUNX1 (21q22.12) / TCF12 (15q21.3) | TCF12 (15q21.3) / CMAS (12p12.1) | TCF12 (15q21.3) / DDX39B (6p21.33) |
|
TCF12 (15q21.3) / FTL (19q13.33) | TCF12 (15q21.3) / KMT2A (11q23.3) | TCF12 (15q21.3) / MGST2 (4q31.1) |
|
TCF12 (15q21.3) / NPAS1 (19q13.32) | TCF12 (15q21.3) / NR4A3 (9q22.33) | TCF12 (15q21.3) / NR4A3 (9q31.1) |
|
TCF12 (15q21.3) / OSCP1 (1p34.3) | TCF12 (15q21.3) / TCF12 (15q21.3) | TCF12 (15q21.3) / TEX9 (15q21.3) |
|
TCF12 (15q21.3) / TMEM255B (13q34) |
Muscle differentiation: more complexity to the network of myogenic regulators. |
Arnold HH, Winter B |
Current opinion in genetics & development. 1998 ; 8 (5) : 539-544. |
PMID 9794824 |
|
Distinguishable patterns of protein-DNA interactions involving complexes of basic helix-loop-helix proteins. |
Doyle K, Zhang Y, Baer R, Bina M |
The Journal of biological chemistry. 1994 ; 269 (16) : 12099-12105. |
PMID 8163514 |
|
Genomic organization of human TCF12 gene and spliced mRNA variants producing isoforms of transcription factor HTF4. |
Gan TI, Rowen L, Nesbitt R, Roe BA, Wu H, Hu P, Yao Z, Kim UJ, O'Sickey T, Bina M |
Cytogenetic and genome research. 2002 ; 98 (4) : 245-248. |
PMID 12826747 |
|
HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. |
Hu JS, Olson EN, Kingston RE |
Molecular and cellular biology. 1992 ; 12 (3) : 1031-1042. |
PMID 1312219 |
|
bHLH transcription factors and mammalian neuronal differentiation. |
Kageyama R, Ishibashi M, Takebayashi K, Tomita K |
The international journal of biochemistry & cell biology. 1997 ; 29 (12) : 1389-1399. |
PMID 9570134 |
|
Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. |
Labelle Y, Zucman J, Stenman G, Kindblom LG, Knight J, Turc-Carel C, Dockhorn-Dworniczak B, Mandahl N, Desmaze C, Peter M |
Human molecular genetics. 1995 ; 4 (12) : 2219-2226. |
PMID 8634690 |
|
Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth. |
Pagliuca A, Gallo P, De Luca P, Lania L |
Cancer research. 2000 ; 60 (5) : 1376-1382. |
PMID 10728702 |
|
A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. |
Sawada S, Littman DR |
Molecular and cellular biology. 1993 ; 13 (9) : 5620-5628. |
PMID 8355705 |
|
Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21). |
Sjögren H, Wedell B, Meis-Kindblom JM, Kindblom LG, Stenman G |
Cancer research. 2000 ; 60 (24) : 6832-6835. |
PMID 11156374 |
|
HTF4: a new human helix-loop-helix protein. |
Zhang Y, Babin J, Feldhaus AL, Singh H, Sharp PA, Bina M |
Nucleic acids research. 1991 ; 19 (16) : page 4555. |
PMID 1886779 |
|
The nucleotide sequence of the human transcription factor HTF4a cDNA. |
Zhang Y, Bina M |
DNA sequence : the journal of DNA sequencing and mapping. 1992 ; 2 (6) : 397-403. |
PMID 1446075 |
|
Localization of the human HTF4 transcription factors 4 gene (TCF12) to chromosome 15q21. |
Zhang Y, Flejter WL, Barcroft CL, Rivière M, Szpirer J, Szpirer C, Bina M |
Cytogenetics and cell genetics. 1995 ; 68 (3-4) : 235-238. |
PMID 7842744 |
|
| Nomenclature |
HGNC (Hugo) | TCF12 11623 |
| Cards |
Atlas | TCF12ID406 |
Entrez_Gene (NCBI) | TCF12 6938 transcription factor 12 |
Aliases | CRS3; HEB; HTF4; HsT17266; |
| TCF-12; bHLHb20; p64 |
GeneCards (Weizmann) | TCF12 |
Ensembl hg19 (Hinxton) | ENSG00000140262 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000140262 [Gene_View]  ENSG00000140262 [Sequence] chr15:57219457-57288516 [Contig_View] TCF12 [Vega] |
ICGC DataPortal | ENSG00000140262 |
TCGA cBioPortal | TCF12 |
AceView (NCBI) | TCF12 |
Genatlas (Paris) | TCF12 |
WikiGenes | 6938 |
SOURCE (Princeton) | TCF12 |
Genetics Home Reference (NIH) | TCF12 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | TCF12 - chr15:57219457-57288516 + 15q21.3 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | TCF12 - 15q21.3 [Description] (hg19-Feb_2009) |
GoldenPath | TCF12 - 15q21.3 [CytoView hg19] TCF12 - 15q21.3 [CytoView hg38] |
ImmunoBase | ENSG00000140262 |
Mapping of homologs : NCBI | TCF12 [Mapview hg19] TCF12 [Mapview hg38] |
OMIM | 600480 615314 |
| Gene and transcription |
Genbank (Entrez) | AI269491 AK022018 AK056961 AK294617 AK294991 |
RefSeq transcript (Entrez) | NM_001306219 NM_001306220 NM_001322151 NM_001322152 NM_001322154 NM_001322156 NM_001322157 NM_001322158 NM_001322159 NM_001322161 NM_001322162 NM_001322164 NM_001322165 NM_003205 NM_207036 NM_207037 NM_207038 NM_207040 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | TCF12 |
Cluster EST : Unigene | Hs.511504 [ NCBI ] |
CGAP (NCI) | Hs.511504 |
Alternative Splicing Gallery | ENSG00000140262 |
Gene Expression | TCF12 [ NCBI-GEO ] TCF12 [ EBI - ARRAY_EXPRESS ]
TCF12 [ SEEK ] TCF12 [ MEM ] |
Gene Expression Viewer (FireBrowse) | TCF12 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 6938 |
GTEX Portal (Tissue expression) | TCF12 |
Human Protein Atlas | ENSG00000140262-TCF12 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q99081 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q99081 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q99081 |
Splice isoforms : SwissVar | Q99081 |
PhosPhoSitePlus | Q99081 |
Domaine pattern : Prosite (Expaxy) | BHLH (PS50888) |
Domains : Interpro (EBI) | bHLH_dom HLH_DNA-bd_sf |
Domain families : Pfam (Sanger) | HLH (PF00010) |
Domain families : Pfam (NCBI) | pfam00010 |
Domain families : Smart (EMBL) | HLH (SM00353) |
Conserved Domain (NCBI) | TCF12 |
DMDM Disease mutations | 6938 |
Blocks (Seattle) | TCF12 |
PDB (RSDB) | 2KNH 4JOL |
PDB Europe | 2KNH 4JOL |
PDB (PDBSum) | 2KNH 4JOL |
PDB (IMB) | 2KNH 4JOL |
Structural Biology KnowledgeBase | 2KNH 4JOL |
SCOP (Structural Classification of Proteins) | 2KNH 4JOL |
CATH (Classification of proteins structures) | 2KNH 4JOL |
Superfamily | Q99081 |
Human Protein Atlas [tissue] | ENSG00000140262-TCF12 [tissue] |
Peptide Atlas | Q99081 |
HPRD | 02725 |
IPI | IPI00012966 IPI00384979 IPI00384333 IPI01010229 IPI01013422 IPI01018775 IPI00940466 IPI01009406 IPI00883875 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q99081 |
IntAct (EBI) | Q99081 |
FunCoup | ENSG00000140262 |
BioGRID | TCF12 |
STRING (EMBL) | TCF12 |
ZODIAC | TCF12 |
| Ontologies - Pathways |
QuickGO | Q99081 |
Ontology : AmiGO | nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription factor complex cytoplasm regulation of transcription by RNA polymerase II immune response muscle organ development transcription factor binding nuclear speck enhancer binding cAMP response element binding protein homodimerization activity intracellular membrane-bounded organelle bHLH transcription factor binding bHLH transcription factor binding transcription regulatory region DNA binding positive regulation of neuron differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II SMAD binding protein heterodimerization activity E-box binding HMG box domain binding RNA polymerase II transcription factor complex regulation of hematopoietic stem cell differentiation |
Ontology : EGO-EBI | nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription factor complex cytoplasm regulation of transcription by RNA polymerase II immune response muscle organ development transcription factor binding nuclear speck enhancer binding cAMP response element binding protein homodimerization activity intracellular membrane-bounded organelle bHLH transcription factor binding bHLH transcription factor binding transcription regulatory region DNA binding positive regulation of neuron differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II SMAD binding protein heterodimerization activity E-box binding HMG box domain binding RNA polymerase II transcription factor complex regulation of hematopoietic stem cell differentiation |
REACTOME | Q99081 [protein] |
REACTOME Pathways | R-HSA-8939236 [pathway] |
NDEx Network | TCF12 |
Atlas of Cancer Signalling Network | TCF12 |
Wikipedia pathways | TCF12 |
| Orthology - Evolution |
OrthoDB | 6938 |
GeneTree (enSembl) | ENSG00000140262 |
Phylogenetic Trees/Animal Genes : TreeFam | TCF12 |
HOGENOM | Q99081 |
Homologs : HomoloGene | TCF12 |
Homology/Alignments : Family Browser (UCSC) | TCF12 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | CGNL1/TCF12 [15q21.3/15q21.3]  [t(15;15)(q21;q21)] |
Fusion : Mitelman | MAP3K5/TCF12 [6q23.3/15q21.3]  [t(6;15)(q23;q21)] |
Fusion : Mitelman | RNF111/TCF12 [15q22.1/15q21.3]  [t(15;15)(q21;q22)] |
Fusion : Mitelman | TCF12/MGST2 [15q21.3/4q31.1]  [t(4;15)(q31;q21)] |
Fusion : Mitelman | TCF12/NPAS1 [15q21.3/19q13.32]  [t(15;19)(q21;q13)] |
Fusion : Mitelman | TCF12/NR4A3 [15q21.3/9q22.33]  [t(9;15)(q31;q21)] |
Fusion : Mitelman | TCF12/TEX9 [15q21.3/15q21.3]  [t(15;15)(q21;q21)] |
Fusion : Mitelman | TCF12/TMEM255B [15q21.3/13q34]  [t(13;15)(q34;q21)] |
Fusion : COSMIC | TCF12 [15q21.3] - NR4A3 [9q31.1] [fusion_754] |
Fusion Portal | CGNL1 15q21.3 TCF12 15q21.3 BRCA |
Fusion Portal | RNF111 15q22.1 TCF12 15q21.3 BRCA |
Fusion Portal | TCF12 15q21.3 FAM70B BRCA |
Fusion Portal | TCF12 15q21.3 MGST2 4q31.1 BRCA |
Fusion Portal | TCF12 15q21.3 NPAS1 19q13.32 PRAD |
Fusion Portal | TCF12 15q21.3 TEX9 15q21.3 BRCA |
Fusion : FusionGDB | 13614 16706 19812 22032 29021 31376 32244 37540 37541 37542 37543 37544 37545 37546 37547 |
| 37548 37549 37550 37551 37552 37553 37554 37555 37556 37557 37558 37559 37560 37561 39942 |
| 5981 |
Fusion : Fusion_Hub | AQP9--TCF12 BCL7C--TCF12 CCNB2--TCF12 CERS6--TCF12 CGNL1--TCF12 COL4A2--TCF12 ECT2--TCF12 FMNL2--TCF12 GLCE--TCF12 GRIN2B--TCF12 HOXB3--TCF12 JARID2--TCF12 JMJD1C--TCF12 KCTD8--TCF12 KMT2A--TCF12 |
| LIPC--TCF12 MAP3K5--TCF12 MGLL--TCF12 MIR548H3--TCF12 NR4A3--TCF12 OSCP1--TCF12 PRTG--TCF12 PTEN--TCF12 RBM33--TCF12 RGMA--TCF12 RNF111--TCF12 RREB1--TCF12 RUNX1--TCF12 SLC16A7--TCF12 SNX2--TCF12 |
| STXBP6--TCF12 TCF12--AKAP13 TCF12--B2M TCF12--BPGM TCF12--BTNL9 TCF12--C10ORF68 TCF12--C15ORF27 TCF12--C1ORF101 TCF12--C7 TCF12--C9ORF64 TCF12--CHD2 TCF12--CHN TCF12--CHP1 TCF12--CLIP2 TCF12--CMAS |
| TCF12--CTBP1 TCF12--DDX39B TCF12--DENND4A TCF12--DSCAM TCF12--DTWD1 TCF12--DYM TCF12--EGLN1 TCF12--EIF5B TCF12--FAM70B TCF12--FTL TCF12--GNAS TCF12--GPR137B TCF12--IL4R TCF12--KMT2A TCF12--MAP3K5 |
| TCF12--MGST2 TCF12--MLIP TCF12--MLL TCF12--MORF4L1 TCF12--NCOA3 TCF12--NDUFA10 TCF12--NEK1 TCF12--NPAS1 TCF12--NPTN TCF12--NR4A3 TCF12--OSCP1 TCF12--PRKCZ TCF12--PRPF40A TCF12--Q6UXQ8_HUMAN TCF12--RAB12 |
| TCF12--RGMA TCF12--RPL12 TCF12--SCAPER TCF12--SERGEF TCF12--SLTM TCF12--SNURF TCF12--SPIN1 TCF12--SPPL2A TCF12--TCF12 TCF12--TEC TCF12--TEX9 TCF12--TMEM255B TCF12--TMEM87A TCF12--TRMT11 TCF12--TTC23 |
| TCF12--UBR5 TCF12--VAPA TCF12--ZBTB44 TCF12--ZNF133 TEC--TCF12 TTC23--TCF12 UBL7--TCF12 WDR78--TCF12 ZNF280D--TCF12 |
Fusion : Quiver | TCF12 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | TCF12 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | TCF12 |
dbVar | TCF12 |
ClinVar | TCF12 |
1000_Genomes | TCF12 |
Exome Variant Server | TCF12 |
ExAC (Exome Aggregation Consortium) | ENSG00000140262 |
GNOMAD Browser | ENSG00000140262 |
Varsome Browser | TCF12 |
Genetic variants : HAPMAP | 6938 |
Genomic Variants (DGV) | TCF12 [DGVbeta] |
DECIPHER | TCF12 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | TCF12 |
| Mutations |
ICGC Data Portal | TCF12 |
TCGA Data Portal | TCF12 |
Broad Tumor Portal | TCF12 |
OASIS Portal | TCF12 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | TCF12 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | TCF12 |
Mutations and Diseases : HGMD | TCF12 |
intOGen Portal | TCF12 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search TCF12 |
DgiDB (Drug Gene Interaction Database) | TCF12 |
DoCM (Curated mutations) | TCF12 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | TCF12 (select a term) |
intoGen | TCF12 |
NCG5 (London) | TCF12 |
Cancer3D | TCF12(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 600480 615314 |
Orphanet | 18668 10369 10368 |
DisGeNET | TCF12 |
Medgen | TCF12 |
Genetic Testing Registry | TCF12
|
NextProt | Q99081 [Medical] |
TSGene | 6938 |
GENETests | TCF12 |
Target Validation | TCF12 |
Huge Navigator |
TCF12 [HugePedia] |
snp3D : Map Gene to Disease | 6938 |
BioCentury BCIQ | TCF12 |
ClinGen | TCF12 (curated) |
| Clinical trials, drugs, therapy |
---|
Chemical/Protein Interactions : CTD | 6938 |
Chemical/Pharm GKB Gene | PA36381 |
Clinical trial | TCF12 |
| Miscellaneous |
---|
canSAR (ICR) | TCF12 (select the gene name) |
DataMed Index | TCF12 |
| Probes |
---|
| Litterature |
---|
PubMed | 91 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | TCF12 |
EVEX | TCF12 |
GoPubMed | TCF12 |
iHOP | TCF12 |