| Embryonic origin | ARMS tends to occur within skeletal muscle and is postulated to derive from precursor cells within the skeletal muscle. Therefore, the embryonic derivation of these tumors is presumed to be mesoderm, the same as that of skeletal muscle. |
| Epidemiology | ARMS accounts for 20-30% of all RMS tumors. Therefore ARMS represents ~1% of all malignancies among children and adolescents, and has an annual incidence of ~1 per million. Many ARMS tumors occur in older children and young adults - this age association characterizes the more prevalent PAX3-FKHR-positive subset of ARMS. In contrast, PAX7-FKHR-positive ARMS as well as fusion-negative tumors tend to occur in younger children. |
| Clinics | ARMS often occurs within skeletal muscle of the extremities but can also occur in other sites including the trunk and head and neck. This tumor often presents as a painless mass, but in other cases, may be discovered from symptoms produced by compression of structures at the primary site. A substantial fraction of patients with ARMS (25-30%) will have metastatic disease at the time of diagnosis. ARMS most frequently spreads to bone marrow, distal nodes, and bone. The standard treatment for ARMS is a combination of surgery, radiation, and intensive chemotherapy. |
| Pathology | Tumor cells in ARMS are relatively small with scant cytoplasm. They have round regular nuclei with a monotonous chromatin pattern. The cells form aggregates interrupted by fibrovascular septae, and within these aggregates, areas of discohesion often form, resulting in spaces that resemble alveoli of the lung. In some ARMS cases, there are few fibrovascular septae, no alveoli-like spaces, and a predominant cellular small round cell population; the term solid variant applies to this situation.
In addition to general immunohistochemical markers to identify RMS, certain markers aid in the identification of ARMS. Immunostaining for myogenin and MyoD show different patterns between ARMS and ERMS, such that most cells within an ARMS tumor stain positive whereas fewer cells within an ERMS tumor stain positive. In addition, based on microarray studies that distinguish fusion-postive ARMS from fusion-negative ERMS, AP2β and p-cadherin were found to be specific markers for the fusion-positive ARMS subtype. |
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| Histopathology of alveolar rhabdomyosarcoma (hematoxylin-eosin, original magnification: 100X; courtesy of Dr. Linda Ernst). |
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| Prognosis | Patients with ARMS tumors have a poorer outcome than patients with ERMS tumors. The 4-year failure free survival rates for patients with localized and metastastic ARMS are 65% and 15%, respectively. Other risk factors that influence outcome of ARMS include primary site, size of primary tumor, extent of local spread, and the presence of nodal and distal metastases.
In an analysis of patients from the IRS-IV study, patients with localized PAX3-FKHR and PAX7-FKHR-positive ARMS had comparable outcomes. In contrast, among patients presenting with metastatic disease, those with PAX3-FKHR-positive tumors had a significantly poorer outcome than those with PAX7-FKHR-positive tumors (4-year overall survival rate of 8% compared to 75%, p=0.0015). |
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