Centre Jean-Perrin, BP 392, 63000 Clermont-Ferrand, France
Chk2 is also involved in the regulation of BRCA1. Under normal conditions the two proteins are associated; after irradiation Chk2 phosphorylates Ser988 of BRCA1. This step is required for their dissociation, and the liberated BRCA1 participates directly in DNA repair and cell cycle arrest.
Finally, Chk2 can provoke apoptosis independently of p53, for example via phosphorylation of PML.
NCBI: 11200 MIM: 604373 HGNC: 16627 Ensembl: ENSG00000183765
dbSNP: 11200 ClinVar: 11200 TCGA: ENSG00000183765 COSMIC: CHEK2
Nancy Uhrhammer
CHEK2 (CHK2 checkpoint homolog (S. pombe))
Atlas Genet Cytogenet Oncol Haematol. 2004-05-01
Online version: http://atlasgeneticsoncology.org/gene/312/gene-fusions-explorer/haematological-explorer/cancer-prone-explorer/