Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University, SS1411 Medical Center North, 1161 21 Avenue S, Nashville, TN 37232, USA
2. GSK3beta promoter single-nucleotide polymorphism (rs334558) influences transcriptional strength, and the less active form was associated with less detrimental clinical features of mood disorders. Effect of rs334558 was studied on grey matter volumes of patients affected by chronic schizophrenia. Carriers of the less active C allele variant showed significantly higher brain volumes in an area encompassing posterior regions of right middle and superior temporal gyrus, within the boundaries of Brodmann area 21. The temporal lobe is the brain parenchymal region with the most consistently documented morphometric abnormalities in schizophrenia, and neuropathological processes in these regions develop soon at the beginning of the illness.
NCBI: 2932 MIM: 605004 HGNC: 4617 Ensembl: ENSG00000082701
dbSNP: 2932 ClinVar: 2932 TCGA: ENSG00000082701 COSMIC: GSK3B
Dinesh Kumar Thotala ; Eugenia M Yazlovitskaya
GSK3B (glycogen synthase kinase 3 beta)
Atlas Genet Cytogenet Oncol Haematol. 2010-04-01
Online version: http://atlasgeneticsoncology.org/gene/40761/img/favicon/gene-explorer/