MTA1 (metastasis-associated gene 1)

2005-04-01 Yasushi Toh , Garth L Nicolson Affiliation

Department of Gastroenterological Surgery National Kyushu Cancer, Center Fukuoka, 811-1395, Japan

Identity

HGNC

MTA1

LOCATION

14q32.33

LOCUSID

9112

ALIAS

FUSION GENES

Show Gene Fusions

DNA/RNA

Transcription

About 2.7 k mRNA; Protein coding region of 714 amino acid residues.

Proteins

Motifs in putative amino acid sequence of MTA1.

A leucine zipper motif and a GATA-type zinc finger motif are found near the mid-portion of the protein. Between them, a SANT domain is found which is homologous to the DNA binding domain of the myb oncogene family. In the amino terminal 200 amino acid residues, there are two highly acidic regions characteristic of the acidic activation domains of many transcription factors. At the carboxyl-terminus is a proline rich stretch whose sequence matches the consensus sequence of the src-homology 3-binding motif. Three putative nuclear localization signals are also present in the sequence.

Description

715 amino acids; about 80 kDa.

Expression

Found in almost all tissues; most abundantly expressed in testis.

Localisation

Nucleus.

Function

MTA1 protein physically interacts with histone deacetylase 1 and is included in a protein nucleosome remodeling complex, NuRD (nucleosome remodeling and histone deacetylation). This protein complex, containing histone deacetylase, plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control.

Homology

MTA2, MTA3.

Implicated in

Disease

Cancer invasion and metastasis as follows:

Overexpression of MTA1 mRNA is correlated with the depth of invasion and lymph node metastasis in gastric and colorectal carcinomas as well as in esophageal carcinomas. The correlation of overexpression of this gene is also reported in lung cancer, thymoma and prostate cancer.

Overexpression of MTA1 protein might be a useful predictor for poor prognosis of human esophageal squamous cell carcinomas.

Forced expression of the MTA1 protein in breast cancer cell line MCF-7 is accompanied by enhancement of the ability of cells to invade an artificial matrix and to grow in an anchorage-independent manner.

Increasing MTA1 expression enhances migration, invasion and anchorage-independent survival of immortalized human keratinocytes.

Article Bibliography

Pubmed ID	Last Year	Title	Authors
11474200	2001	Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization.	Cui Q et al
12705869	2003	MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.	Fujita N et al
14871807	2004	The role of metastasis-associated protein 1 in prostate cancer progression.	Hofer MD et al
14613024	2003	Emerging roles of MTA family members in human cancers.	Kumar R et al
11948399	2002	Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes.	Mahoney MG et al
11146623	2001	Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor.	Mazumdar A et al
10967548	2000	Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides.	Nawa A et al
11804687	2002	Expression of the MTA1 mRNA in advanced lung cancer.	Sasaki H et al
11689291	2001	Expression of the MTA1 mRNA in thymoma patients.	Sasaki H et al
10840944	2000	Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1.	Toh Y et al
10206283	1999	Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas.	Toh Y et al
15095300	2004	Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas.	Toh Y et al
9291440	1997	Overexpression of the MTA1 gene in gastrointestinal carcinomas: correlation with invasion and metastasis.	Toh Y et al
8083195	1994	A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses.	Toh Y et al
9885572	1998	NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.	Xue Y et al

Other Information

Locus ID:

NCBI: 9112
MIM: 603526
HGNC: 7410
Ensembl: ENSG00000182979

Variants:

dbSNP: 9112
ClinVar: 9112
TCGA: ENSG00000182979
COSMIC: MTA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000182979	ENST00000331320	Q13330
ENSG00000182979	ENST00000405646	Q13330
ENSG00000182979	ENST00000406191	E7ESY4
ENSG00000182979	ENST00000424723	H7C3F3
ENSG00000182979	ENST00000434050	H0Y4T7
ENSG00000182979	ENST00000435036	F8W9Y9
ENSG00000182979	ENST00000438610	Q13330
ENSG00000182979	ENST00000551236	H0YIT0

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
SUMOylation	REACTOME	R-HSA-2990846
SUMO E3 ligases SUMOylate target proteins	REACTOME	R-HSA-3108232
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase I Transcription	REACTOME	R-HSA-73864
RNA Polymerase I Promoter Clearance	REACTOME	R-HSA-73854
RNA Polymerase I Transcription Initiation	REACTOME	R-HSA-73762
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HDACs deacetylate histones	REACTOME	R-HSA-3214815
SUMOylation of transcription factors	REACTOME	R-HSA-3232118
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	REACTOME	R-HSA-427389

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36689059	2023	MTA1 as negative prognostic marker in vulvar carcinoma.	0
36689059	2023	MTA1 as negative prognostic marker in vulvar carcinoma.	0
32126261	2022	Metastasis-associated protein 1-mediated antitumor and anticancer activity of dietary stilbenes for prostate cancer chemoprevention and therapy.	12
35369814	2022	Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity.	4
35490918	2022	RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma.	7
35642705	2022	miR-30 inhibits the progression of osteosarcoma by targeting MTA1.	2
35792131	2022	MTA1: A Vital Modulator in Prostate Cancer.	1
35951452	2022	Correlation between metastasis-associated gene 1 expression and tumor-associated macrophages in non-small cell lung cancer.	1
36041657	2022	RNAi Screen Identifies MTA1 as an Epigenetic Modifier of Differentiation Commitment in Human HSPCs.	2
36164698	2022	[The role and mechanism of tumor metastasis-associated gene 1 in radiosensitivity of HeLa cells].	0
36210748	2022	Metastasis-associated protein 1: A potential driver and regulator of the hallmarks of cancer.	0
32126261	2022	Metastasis-associated protein 1-mediated antitumor and anticancer activity of dietary stilbenes for prostate cancer chemoprevention and therapy.	12
35369814	2022	Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity.	4
35490918	2022	RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma.	7
35642705	2022	miR-30 inhibits the progression of osteosarcoma by targeting MTA1.	2

Citation

Yasushi Toh ; Garth L Nicolson

MTA1 (metastasis-associated gene 1)

Atlas Genet Cytogenet Oncol Haematol. 2005-04-01

Online version: http://atlasgeneticsoncology.org/gene/41443/favicon/js/lib/hgnc