Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Science Center, Beijing, 100191, China
Programmed Cell Death 5 (PDCD5) was originally identified as an apoptosis-accelerating molecule that was widely expressed and well-conserved in the process of evolution. It has significant homology to the corresponding proteins of species ranging from yeast to mice gene. PDCD5 can accelerate apoptosis in different type of cells in response to different stimuli, and can also induce different types of cell death, including paraptosis-like cell death. In cells undergoing apoptosis, PDCD5 rapidly translocates from the cytoplasm to the nucleus before phosphatidylserine is externalized and genomic DNA undergoes fragmentation. PDCD5 interacts with TIP60 and TP53 and plays an important positive role in TIP60-P53 signaling pathway. PDCD5 also participates in immune regulation through regulating the level of FOXP3 protein and percentage of regulatory T cells. Dysfunction of PDCD5 was associated in many diseases including different tumors, rheumatoid arthritis and presbycusis, etc.
NCBI: 9141 MIM: 604583 HGNC: 8764 Ensembl: ENSG00000105185
dbSNP: 9141 ClinVar: 9141 TCGA: ENSG00000105185 COSMIC: PDCD5
Yingyu Chen ; Ge Li
PDCD5 (programmed cell death 5)
Atlas Genet Cytogenet Oncol Haematol. 2014-10-01
Online version: http://atlasgeneticsoncology.org/gene/41676/js/lib/js/_common.js