RhoBTB1 is one of the three members of the RhoBTB family. All RhoBTB proteins are characterized by a GTPase domain followed by a proline-rich region, a tandem of two BTB domains and a C-terminal putative RING finger domain. RHOBTB1 is a putative tumour suppressor gene. Expression of RHOBTB1 has been found decreased in diverse tumors including kidney, breast, stomach and colon cancers and head and neck squamous cell carcinomas. RhoBTB1 is a component of Cullin 3-dependent ubiquitin ligase complexes but its role in tumorigenesis is unknown.
NCBI: 9886 MIM: 607351 HGNC: 18738 Ensembl: ENSG00000072422
dbSNP: 9886 ClinVar: 9886 TCGA: ENSG00000072422 COSMIC: RHOBTB1
Kristina Schenková ; Shuo Cai ; Francisco Rivero
RHOBTB1 (Rho-related BTB domain containing 1)
Atlas Genet Cytogenet Oncol Haematol. 2016-02-01
Online version: http://atlasgeneticsoncology.org/gene/42981/css/js/_common.js
2008-12-01 RHOBTB1 (Rho-related BTB domain containing 1) by Kristina Schenková,Francisco Rivero  Affiliation