MIR146B (microRNA 146b)
2012-12-01 Amandine Garcia , Sylvie Mazoyer AffiliationCNRS UMR5286 Inserm U1052, Universite Lyon 1, Cancer Research Centre of Lyon, Centre Leon Berard, Lyon, France
DNA/RNA
Note

Description
Transcription
pre-miR-146b
miRBase accession number: MI0003129.
Length: 73 nucleotides.
Sequence: 5-CCUGGCACUGAGAACUGAAUUCCAUAGGCUGUGAGCUCUAGCAAUGCCCUGUGGACUCAGUUCUGGUGCCCGG-3
mature miR-146b-5p
miRBase accession number: MIMAT0002809.
Length: 22 nucleotides.
Sequence: 5-UGAGAACUGAAUUCCAUAGGCU-3
mature miR-146b-3p
miRBase accession number: MIMAT0004766.
Length: 22 nucleotides.
Sequence: 5-UGCCCUGUGGACUCAGUUCUGG-3
Pseudogene
Proteins
Note
Implicated in
A second study, based on 20 samples only, identified specific expression of a set of seven microRNAs (including miR-146b-5p) in normal basal cells but not in basal-like breast cancers, which are close to triple negative breast cancers. miR-146b-5p may have an elevated expression in malignant myoepithelioma of the breast (Bockmeyer et al., 2011).
The second study depicted a direct target of miR-146b-5p, BRCA1 (BReast CAncer 1), one of the two major breast cancer predisposition genes. The binding of miR-146-5p to the BRCA1 3UTR decreased the expression of BRCA1, induced cellular proliferation and reduced the homologous recombination rate. miR-146b seemed to have an important role in tumour progression via BRCA1 (Garcia et al., 2011).
Article Bibliography
Other Information
Locus ID:
NCBI: 574447
MIM: 610567
HGNC: 32079
Ensembl: ENSG00000202569
miRBase:
Variants:
dbSNP: 574447
ClinVar: 574447
TCGA: ENSG00000202569
COSMIC: MIR146B
RNA/Proteins
References
Citation
Amandine Garcia ; Sylvie Mazoyer
MIR146B (microRNA 146b)
Atlas Genet Cytogenet Oncol Haematol. 2012-12-01
Online version: http://atlasgeneticsoncology.org/gene/50855/mir146b