MOB4 (MOB family member 4, phocein)

2014-10-01  

Identity

HGNC
MOB4
LOCATION
2q33.1
LOCUSID
25843
ALIAS
2C4D,CGI-95,MOB1,MOB3,MOBKL3,PHOCN,PREI3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25843
MIM: 609361
HGNC: 17261
Ensembl: ENSG00000115540

Variants:

dbSNP: 25843
ClinVar: 25843
TCGA: ENSG00000115540
COSMIC: MOB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115540ENST00000233892Q9Y3A3
ENSG00000115540ENST00000323303Q9Y3A3
ENSG00000115540ENST00000323303A0A024R3X9
ENSG00000115540ENST00000409355F8W8B0
ENSG00000115540ENST00000409360Q9Y3A3
ENSG00000115540ENST00000409916B4DM50
ENSG00000115540ENST00000417097F8WAQ8
ENSG00000115540ENST00000448447Q9Y3A3

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372596702023Mob4 is essential for spermatogenesis in Drosophila melanogaster.0
372596702023Mob4 is essential for spermatogenesis in Drosophila melanogaster.0
300723782018The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.39
300723782018The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.39
248723892014hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.12
248723892014hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.12
183628902008Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.25
183628902008Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.25

Citation

Dessen P

MOB4 (MOB family member 4, phocein)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54904/js/lib/humanGenome