del(17p) in non-Hodgkins lymphoma (NHL)

2000-12-01   Gianluigi Castoldi , Antonio Cuneo 

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology

Disease

virtually all histologic subsets of NHL may harbour a 17p- chromosome; there is variation in the reported incidence due to heterogeneity of histologic classification and to the different sensitivity of the detection methods
  • 10 to 15% of follicle centre cell lymphoma (FCCL) and mantle cell lymphomas (MCL) may carry a 17p- chromosome; minority of marginal zone B-cell lymphomas may be associated with 17p deletion
  • this anomaly is rarely found in T-cell NHL

    • Prognosis

    the 17p- chromosome was reported to predict for a poor prognosis in low grade lymphomas; any abnormality of chromosome 17 was also reported to negatively affect survival in lymphomas of all histologic grades

    Cytogenetics

    Cytogenetics morphological

  • the deleted segment may vary in size and many cases with sub-microscopic deletions involving the 17p13 band were reported by FISH; cases with unbalanced 17p translocations leading to 17p loss were also described; these cases may be associated with dicentric rearrangements
  • the 17p- is usually associated with transformation of a low-grade FCCL with t(14;18) into a high grade lymphoma; likewise, there is a higher incidence of 17p- in the blastoid variant of MCL with t(11,14) than in the typical form

    • Cytogenetics molecular

    the deletion may be detected by G or R-banding; FISH using a 17p13/p53 probe is recommended, this technique being more sensitive than conventional cytogenetics

    Genes Involved and Proteins

    Note
    the majority of cases with 17p- carry a p53 gene deletion, associated with mutation of the remaining allele; there may be a small fraction of cases with a more distal deletion involving an as yet unidentified locus

    Bibliography

    Pubmed IDLast YearTitleAuthors

    Summary

    Note

    the 17p- chromosome is a secondary change in most cases of NHL
    Atlas Image
    del(17p)  Hybridization with the LSI p53/CEP17 and LSI p53 probes (Abbott molecular, US) showing 2 green and 2 red signals on normal metaphase (A) and only 1 red signal in metaphase and interphase cells with 17p deletion (B,C) u2013 Courtesy Adriana Zamecnikova. Insert: del(17p) G- banding u2013 Top: Courtesy Melanie Zenger and Claudia Haferlach: Bottom: u2013 Courtesy Adriana Zamecnikova.

    Citation

    Gianluigi Castoldi ; Antonio Cuneo

    del(17p) in non-Hodgkins lymphoma (NHL)

    Atlas Genet Cytogenet Oncol Haematol. 2000-12-01

    Online version: http://atlasgeneticsoncology.org/haematological/2083/tumors-explorer/welcome