PTPRK/RSPO3 (6q22)

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

PTPRK

Location

6q22.33

Gene name

RSPO3

Location

6q22.33

Highly cited references

Pubmed IDYearTitleCitations
267008062016Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function.95
286958962017R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.40
269245692016Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.35
248477612014RSPO fusion transcripts in colorectal cancer in Japanese population.21
322176382020Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.16
285437082017Comprehensive characterization of RSPO fusions in colorectal traditional serrated adenomas.11
301799002019Acquisition of WNT Pathway Gene Alterations Coincides With the Transition From Precursor Polyps to Traditional Serrated Adenomas.10
309163652019EIF3E-RSPO2 and PIEZO1-RSPO2 fusions in colorectal traditional serrated adenoma.9
319348542020The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer.8
357517852022Genomic and transcriptomic analysis of Korean colorectal cancer patients.0
354493122022Comprehensive genetic characterization of rectal cancer in a large cohort of Japanese patients: differences according to tumor location.0
357156282022Clinicopathological and molecular characteristics of RSPO fusion-positive colorectal cancer.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
228951932012Recurrent R-spondin fusions in colon cancer.Seshagiri S et al
248477612014RSPO fusion transcripts in colorectal cancer in Japanese population.Shinmura K et al

Citation

Jean-Loup Huret ; Philippe Dessen

PTPRK/RSPO3 (6q22)

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/107252/css/lib/favicon/manifest.json