t(8;8)(q13;q21) HEY1::NCOA2

Genes involved

HEY1 (8q21.13)

NCOA2 (8q13.3)

Tumor type

Mesenchymal chondrosarcomas

Highly cited references

Pubmed IDYearTitleCitations
353429472022Genomic profiling identifies genes and pathways dysregulated by HEY1-NCOA2 fusion and shines a light on mesenchymal chondrosarcoma tumorigenesis.75
372122822023HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice.60
337083642021Rare tumors in pediatric age group: Single center experience from Saudi Arabia.46
252023772014Primary spinal intradural mesenchymal chondrosarcoma with detection of fusion gene HEY1-NCOA2: A paediatric case report and review of the literature.45
358751372022Update of Key Clinical, Histological and Molecular Features of Malignant Bone Tumours Arising in the Craniofacial Skeleton.45
383320522024Small cell osteosarcoma versus fusion-driven round cell sarcomas of bone: retrospective clinical, radiological, pathological, and (epi)genetic comparison with clinical implications.38
377283062023Clinical diagnostic and radiographic features of a primary intradural spinal chondrosarcoma in a young adult: illustrative case.38
231854132012Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma.36
318972032020Primary mesenchymal chondrosarcoma of the kidney without HEY1-NCOA2 and IRF2BP2-CDX1 fusion: A case report and review.34
308191342019Primary paediatric epidural sarcomas: molecular exploration of three cases.34
261464782015Mesenchymal Chondrosarcoma in Children and Young Adults: A Single Institution Retrospective Review.31
248399992014Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma.30
356722792022Mesenchymal chondrosarcoma of the head and neck with HEY1::NCOA2 fusion: A clinicopathologic and molecular study of 13 cases with emphasis on diagnostic pitfalls.29
314845142019Primary intradural extramedullary spinal mesenchymal chondrosarcoma: case report and literature review.26
220341772012Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data.24
323224502020Intracranial Mesenchymal Chondrosarcoma Lacking the Typical Histopathological Features Diagnosed by HEY1-NCOA2 Gene Fusion.20
391656472024Case report: A mesenchymal chondrosarcoma with alternative HEY1::NCOA2 fusions in the sella turcica.17
367523302023Primary mesenchymal chondrosarcoma of the lung.5
347424832021Malignant Cartilage-Forming Tumors.0
232528722012Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma.0
348370642022Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma.0
287975012017Integrating Morphology and Genetics in the Diagnosis of Cartilage Tumors.0
295821892018Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology.0
253360102014Mesenchymal chondrosarcoma diagnosed on FISH for HEY1-NCOA2 fusion gene.0
275448022016Pancreatic involvement by mesenchymal chondrosarcoma harboring the HEY1-NCOA2 gene fusion.0
295968962018Minute mesenchymal chondrosarcoma within osteochondroma: an unexpected diagnosis confirmed by HEY1-NCOA2 fusion.0
305826582019An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing.0
364166712023Novel low-grade renal spindle cell neoplasm with HEY1::NCOA2 fusion that is distinct from mesenchymal chondrosarcoma.0
324865422020[Detection and analysis of HEY1-NCOA2 fusion gene in mesenchymal chondrosarcoma].0
376884102024Detection of mesenchymal chondrosarcoma in pleural effusion with immunocytochemistry and determination of HEY1::NCOA2 fusion by next-generation sequencing on cell block.0
320606852020[Cartilage tumors: morphology, genetics, and current aspects of target therapy].0
241241452013Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion.0
325649222020Hybrid sclerosing epithelioid fibrosarcoma/low grade fibromyxoid sarcoma arising in the small intestine with distinct HEY1-NCOA2 gene fusion.0
372256442023NKX3.1 immunohistochemistry and methylome profiling in mesenchymal chondrosarcoma: additional diagnostic value for a well-defined disease?0
295592362018Mesenchymal chondrosarcomas showing immunohistochemical evidence of rhabdomyoblastic differentiation: a potential diagnostic pitfall.0
346198702021[Extraskeletal mesenchymal chondrosarcoma in central nerve system: a clinicopathological analysis].0
336401592021NKX3.1 immunohistochemistry is highly specific for the diagnosis of mesenchymal chondrosarcomas: experience in the Australian population.0
352172662022A mesenchymal chondrosarcoma with aberrant nuclear expression of STAT6: a potential diagnostic pitfall.0
291040832018Development and Evaluation of a Pan-Sarcoma Fusion Gene Detection Assay Using the NanoString nCounter Platform.0
276174022016Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line.0
259072642015Intraparenchymal mesenchymal chondrosarcoma of the frontal lobe--a case report and molecular detection of specific gene fusions from archival FFPE sample.0
310330802019Detecting disease-defining gene fusions in unclassified round cell sarcomas using anchored multiplex PCR/targeted RNA next-generation sequencing-Molecular and clinicopathological characterization of 16 cases.0

Bibliography

Pubmed IDPublication YearTitleAuthors
248399992014Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma.Panagopoulos I, et al
231854132012Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma.Nyquist KB, et al