JUN (V-Jun sarcoma virus 17 oncogene homolog (avian))

2003-01-01   Fei Chen 

Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

Identity

HGNC
LOCATION
1p32.1
LOCUSID
ALIAS
AP-1,AP1,c-Jun,cJUN,p39
FUSION GENES

DNA/RNA

Description

The Jun gene maps on chromosome 1p32-p31 spanning 333799bp. The study by Hattori et al suggested that the Jun gene has no introns.

Transcription

Due to 5 and 3 heterogeneities, several transcripts of Jun mRNA has been identified. The predicted molecular weight of JUN protein is 41.9 kD.

Proteins

Atlas Image

Description

The JUN protein was originally identified as an oncoprotein encoded by a cellular insert in the genome of avian sarcoma virus 17. Following studies demonstrated that JUN is a critical component of AP-1 transcription factor that recognizes the palindromic DNA sequence TGAC/GTCA, the so-called TPA response element (TRE), in the promoter or intron region of a number of genes. JUN can stably associate with itself or Fos protein to form AP-1 complex. JUN can also interact with some activating transcription factor (ATF) members, such as ATF2, ATF3 and ATF4, to form heterodimers that bind to the cAMP-responsive element (CRE) DNA sequence, TGACGTCA. All JUN proteins from different species contain a N-terminal JNK docking domain (delta domain) adjacent to the JNK phosphorylating site Ser63/73. In the C-terminal, there is a basic domain for DNA binding, followed by a nuclear localization signal (NLS) and a leucine zipper motif for dimerization with partner proteins.

Expression

Ubiquitously expressed.

Localisation

Nuclear and mitochondria.

Function

JUN is the most important component of AP-1 transcription factors, and its transcriptional activity is possibly attenuated by JUNB or JUND. It has been well accepted that JUN regulates cell proliferation, apoptosis and transformation. JUN promotes cell cycle transition from G1 phase to S phase by up-regulating cyclin D1 expression and antagonizing the function of p53and p21. The JUN protein is involved in both the induction and prevention of apoptosis, possibly dependent on the types and development stages of cells. JUN-dependent induction of pro-apoptotic protein FasL and Bim has been demonstrated in several experimental systems. However, evidence indicating an anti-apoptotic activity of JUN has also been provided by the fact that deficiency of Jun gene causes massive hepatocyte apoptosis. The potential oncogenic transformation of JUN has been revealed by overexpression experiments. This effect of JUN may partially through the induction of certain JUN targeting genes, such as heparin-bind epidermal growth factor-like growth factor (HB-EGF), proliferin and Jun-activated gene in chicken embryo fibroblasts (JAC).

Implicated in

Entity name
Inflammation
Oncogenesis
Overexpression of JUN has been observed in certain human cancer. However, no mutation, rearrangement or amplification of Jun gene has been reported.

Bibliography

Pubmed IDLast YearTitleAuthors
31944151988Structure and chromosomal localization of the functional intronless human JUN protooncogene.Hattori K et al
119887582002AP-1 as a regulator of cell life and death.Shaulian E et al
121893882002Fortuitous convergences: the beginnings of JUN.Vogt PK et al

Other Information

Locus ID:

NCBI: 3725
MIM: 165160
HGNC: 6204
Ensembl: ENSG00000177606

Variants:

dbSNP: 3725
ClinVar: 3725
TCGA: ENSG00000177606
COSMIC: JUN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177606ENST00000371222P05412

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
ErbB signaling pathwayKEGGko04012
ApoptosisKEGGko04210
Wnt signaling pathwayKEGGko04310
Focal adhesionKEGGko04510
Tight junctionKEGGko04530
Toll-like receptor signaling pathwayKEGGko04620
T cell receptor signaling pathwayKEGGko04660
B cell receptor signaling pathwayKEGGko04662
GnRH signaling pathwayKEGGko04912
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Colorectal cancerKEGGko05210
Renal cell carcinomaKEGGko05211
MAPK signaling pathwayKEGGhsa04010
ErbB signaling pathwayKEGGhsa04012
ApoptosisKEGGhsa04210
Wnt signaling pathwayKEGGhsa04310
Focal adhesionKEGGhsa04510
Tight junctionKEGGhsa04530
Toll-like receptor signaling pathwayKEGGhsa04620
T cell receptor signaling pathwayKEGGhsa04660
B cell receptor signaling pathwayKEGGhsa04662
GnRH signaling pathwayKEGGhsa04912
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Renal cell carcinomaKEGGhsa05211
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Influenza AKEGGko05164
Influenza AKEGGhsa05164
PertussisKEGGko05133
PertussisKEGGhsa05133
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
DiseaseREACTOMER-HSA-1643685
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
MAPK targets/ Nuclear events mediated by MAP kinasesREACTOMER-HSA-450282
Activation of the AP-1 family of transcription factorsREACTOMER-HSA-450341
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Developmental BiologyREACTOMER-HSA-1266738
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
IL-17 signaling pathwayKEGGko04657
Fluid shear stress and atherosclerosisKEGGko05418
IL-17 signaling pathwayKEGGhsa04657
Fluid shear stress and atherosclerosisKEGGhsa05418
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134992438CAMK1DGenePathwayassociated
PA24684AKT1GenePathwayassociated
PA24685AKT2GenePathwayassociated
PA24686AKT3GenePathwayassociated
PA26048CAMK1GenePathwayassociated
PA26049CAMK1GGenePathwayassociated
PA283MAPK8GenePathwayassociated23922006
PA30616MAPK1GenePathwayassociated
PA30621MAPK14GenePathwayassociated23922006
PA30622MAPK3GenePathwayassociated
PA337STAT3GenePathwayassociated
PA33759PRKCAGenePathwayassociated
PA33761PRKCBGenePathwayassociated
PA33766PRKCGGenePathwayassociated
PA338STAT5AGenePathwayassociated
PA36183STAT1GenePathwayassociated
PA36184STAT2GenePathwayassociated
PA36185STAT4GenePathwayassociated
PA36186STAT5BGenePathwayassociated
PA90CAMK2AGenePathwayassociated
PA91CAMK2BGenePathwayassociated
PA92CAMK2DGenePathwayassociated
PA93CAMK2GGenePathwayassociated

References

Pubmed IDYearTitleCitations
222718782012Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy.170
183848142008miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism.168
147394642004Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.139
188386752008Genome-wide studies highlight indirect links between human replication origins and gene regulation.127
204797622011Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood.118
153141852004NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.111
153854742004NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium.109
192490082009Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.109
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
183470712008Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction.96

Citation

Fei Chen

JUN (V-Jun sarcoma virus 17 oncogene homolog (avian))

Atlas Genet Cytogenet Oncol Haematol. 2003-01-01

Online version: http://atlasgeneticsoncology.org/gene/151/jun