EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)

2000-07-01 Jean-Loup Huret Affiliation

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC

EIF4A2

LOCATION

3q27.3

IMAGE

LEGEND

Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics

LOCUSID

1974

ALIAS

BM-010,DDX2B,EIF4A,EIF4F,eIF-4A-II,eIF4A-II

FUSION GENES

Show Gene Fusions

DNA/RNA

Transcription

1.9 kb mRNA; 1223 bp coding sequence

Proteins

Description

407 amino acids; 4.6 kDa; NH2-term, ATP binding site, DEAD box, COOH-term

Expression

wide; also expressed in the embryo

Function

ADP/ATP binding; RNA helicase; binds mRNA to the ribosome: role in initiation of protein synthesis; also -binds single strand DNA

Homology

DEAD box proteins, in particular other EIF4A

Implicated in

Entity name

t(3;18)(q27;p11.2) --> EIF4A2/ BCL6

Disease

non-Hodgkin lymphoma

Prognosis

yet unknown (only 1case available)

Hybrid gene

5 EIF4A2 - 3 BCL6; EIF4A2 fuses with the second exon of BCL6

Fusion protein

no fusion protein, but promoter exchange

Oncogenesis

BCL6 is a transcription repressor; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation

Article Bibliography

Pubmed ID	Last Year	Title	Authors
10523622	1999	Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII.	Li Q et al
9485365	1998	The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes.	Lorsch JR et al
8521730	1995	Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2.	Sudo K et al
10637510	1999	Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples.	Yoshida S et al

Other Information

Locus ID:

NCBI: 1974
MIM: 601102
HGNC: 3284
Ensembl: ENSG00000156976

Variants:

dbSNP: 1974
ClinVar: 1974
TCGA: ENSG00000156976
COSMIC: EIF4A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000156976	ENST00000323963	Q14240
ENSG00000156976	ENST00000425053	E7EQG2
ENSG00000156976	ENST00000426808	E9PBH4
ENSG00000156976	ENST00000429589	E9PBH4
ENSG00000156976	ENST00000440191	Q14240
ENSG00000156976	ENST00000441007	C9JUF0
ENSG00000156976	ENST00000443963	F8WE11
ENSG00000156976	ENST00000445596	E7EMV8
ENSG00000156976	ENST00000498746	J3KSN7

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
eIF4F complex	KEGG	hsa_M00428
eIF4F complex	KEGG	M00428
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	REACTOME	R-HSA-72662
Translation initiation complex formation	REACTOME	R-HSA-72649
Ribosomal scanning and start codon recognition	REACTOME	R-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunit	REACTOME	R-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expression	REACTOME	R-HSA-156827
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
Gene Expression	REACTOME	R-HSA-74160
Deadenylation-dependent mRNA decay	REACTOME	R-HSA-429914
Deadenylation of mRNA	REACTOME	R-HSA-429947

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36528028	2023	Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy.	2
37331603	2023	Monitoring RNA restructuring in a human cell-free extract reveals eIF4A-dependent and eIF4A-independent unwinding activity.	2
37485550	2023	Dystonia Linked to EIF4A2 Haploinsufficiency: A Disorder of Protein Translation Dysfunction.	2
36528028	2023	Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy.	2
37331603	2023	Monitoring RNA restructuring in a human cell-free extract reveals eIF4A-dependent and eIF4A-independent unwinding activity.	2
37485550	2023	Dystonia Linked to EIF4A2 Haploinsufficiency: A Disorder of Protein Translation Dysfunction.	2
31088567	2019	Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer.	31
31180491	2019	DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.	14
31308851	2019	MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer to paclitaxel by downregulating EIF4A2.	28
31791371	2019	eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR.	29
31088567	2019	Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer.	31
31180491	2019	DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.	14
31308851	2019	MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer to paclitaxel by downregulating EIF4A2.	28
31791371	2019	eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR.	29
29842983	2018	eIF4A2 is a host factor required for efficient HIV-1 replication.	13

Citation

Jean-Loup Huret

EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)

Atlas Genet Cytogenet Oncol Haematol. 2000-07-01

Online version: http://atlasgeneticsoncology.org/gene/262/eif4a2-(eukaryotic-translation-initiation-factor-4a-isoform-2)