TCL1B (T-cell leukemia/lymphoma 1B)
2008-01-01 Herbert Eradat , Michael A Teitell AffiliationDepartments of Medicine (H.E.), Pathology, Laboratory Medicine (M.A.T.), David Geffen School of Medicine at UCLA, 675 Charles Young Drive South, 4-762 MacDonald Research Laboratories, Los Angeles, CA 90095-1732, USA
DNA/RNA
Description
6.5 kb TCL1B cDNA. 4 exons (181, 171, 69, 697 bp); centromere - exons 1 to 4 - telomere orientation; only the first three exons are coding. Located 15-16 kb centromeric of TCL1A.
Transcription
TCL1B transcripts detected by RT-PCR or Northern blot in fetal tissues (liver, thymus, spleen, and kidney) and in testis, placenta, peripheral blood lymphocytes, kidney, tonsil, spleen, and bone marrow.
Pseudogene
Localized to 5q12-5q13, lacks an initiating ATG and introns and has a stop codon in the middle of the ORF.
Proteins
Description
15 kDa, 128 amino acid protein; one domain with a beta-barrel topology.
Expression
Undefined
Localisation
Undefined
Function
Undefined in vivo but binds and coactivates AKT (protein kinase B) in vitro and in transfected cell lines.
Homology
30% identical to TCL1A, 60% similar to TCL1A
36% identical to MTCP1, 63% similar to MTCP1
36% identical to MTCP1, 63% similar to MTCP1
Implicated in
Entity name
Entity name
Expression in some Burkitt lymphoma cell lines.
Disease
May be upregulated in T-cell prolymphocytic leukemia (T-PLL) with t(14;14)(q11;q32.1) and in Burkitt lymphoma .
Oncogenesis
TCL1 over expression by chromosomal rearrangement is a critical oncogenetic mechanism in T-PLL; a role for TCL1B over expression in oncogenesis is not yet shown.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11707444 | 2002 | Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. | Laine J et al |
| 10716693 | 2000 | Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. | Pekarsky Y et al |
| 10344735 | 1999 | Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus. | Sugimoto J et al |
| 16056259 | 2005 | The TCL1 family of oncoproteins: co-activators of transformation. | Teitell MA et al |
Other Information
Locus ID:
NCBI: 9623
MIM: 603769
HGNC: 11649
Ensembl: ENSG00000213231
Variants:
dbSNP: 9623
ClinVar: 9623
TCGA: ENSG00000213231
COSMIC: TCL1B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000213231 | ENST00000340722 | O95988 |
| ENSG00000213231 | ENST00000340722 | A0A024R6P4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| PI3K-Akt signaling pathway | KEGG | hsa04151 |
| PI3K-Akt signaling pathway | KEGG | ko04151 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 20228224 | 2010 | Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications. | 24 |
| 20800603 | 2010 | Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. | 14 |
| 20228224 | 2010 | Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications. | 24 |
| 20800603 | 2010 | Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. | 14 |
Citation
Herbert Eradat ; Michael A Teitell
TCL1B (T-cell leukemia/lymphoma 1B)
Atlas Genet Cytogenet Oncol Haematol. 2008-01-01
Online version: http://atlasgeneticsoncology.org/gene/354/tcl1b-(t-cell-leukemia-lymphoma-1b)
