RAP1GDS1 (RAP1, GTP-GDP dissociation stimulator 1)
2003-10-01 Franck Viguié AffiliationLaboratoire de Cytogenetique - Service dHematologie Biologique, Hopital Hotel-Dieu - 75181 Paris Cedex 04, France
DNA/RNA
Description
181.2 kb - 15 exons
Transcription
mRNA 2487 bases
Proteins
Description
rap1gds, also refered as smgGDS - 61.1 kDa, 558 aa. Contains in major part an armadillo motif, which is composed of tandemly repeated sequences of 43 amino acid residues.
Expression
Ubiquitary, high level of expression in central nervous system.
Function
Acts as guanine nucleotide exchange factor (GEF). Activates GDP/GTP exchange reaction on numerous small proteins with GTPase activity (G proteins) containing a C-terminal polybasic region (PBR), including Ras and Rho family GTPases such as rap1a, rap1b, K-ras, rac1, rac2, rhoA, ralB. These proteins play a pivotal role in cell proliferation, differentiation and oncogenic transformation.
Homology
With other mammalian rap1gds1 proteins.
Implicated in
Entity name
Disease
T cell acute lymphocytic leukemia.
Cytogenetics
Additional anomalies in 2/3 cases.
Hybrid gene
Quasi totality of RAP1GDS1 fused with 5 part of NUP98.
Fusion protein
Chimeric protein 5 -NUP98 - RAP1GDS1 - 3.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10477737 | 1999 | The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia. | Hussey DJ et al |
| 10929031 | 2000 | t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia. | Mecucci C et al |
| 11948427 | 2002 | SmgGDS displays differential binding and exchange activity towards different Ras isoforms. | Vikis HG et al |
| 7526840 | 1994 | Inhibition of adenylate cyclase activity by galanin in rat insulinoma cells is mediated by the G-protein Gi3. | de Mazancourt P et al |
Other Information
Locus ID:
NCBI: 5910
MIM: 179502
HGNC: 9859
Ensembl: ENSG00000138698
Variants:
dbSNP: 5910
ClinVar: 5910
TCGA: ENSG00000138698
COSMIC: RAP1GDS1
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33574130 | 2021 | Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation. | 3 |
| 33574130 | 2021 | Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation. | 3 |
| 32019878 | 2020 | Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy. | 10 |
| 32431071 | 2020 | Mutated RAP1GDS1 causes a new syndrome of dysmorphic feature, intellectual disability & speech delay. | 12 |
| 32019878 | 2020 | Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy. | 10 |
| 32431071 | 2020 | Mutated RAP1GDS1 causes a new syndrome of dysmorphic feature, intellectual disability & speech delay. | 12 |
| 31197034 | 2019 | The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases. | 9 |
| 31197034 | 2019 | The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases. | 9 |
| 29940100 | 2018 | SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent. | 6 |
| 30190425 | 2018 | GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism. | 14 |
| 29940100 | 2018 | SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent. | 6 |
| 30190425 | 2018 | GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism. | 14 |
| 28630045 | 2017 | Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding. | 12 |
| 28806394 | 2017 | SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. | 10 |
| 28630045 | 2017 | Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding. | 12 |
Citation
Franck Viguié
RAP1GDS1 (RAP1, GTP-GDP dissociation stimulator 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-10-01
Online version: http://atlasgeneticsoncology.org/gene/400/rap1gds1-(rap1-gtp-gdp-dissociation-stimulator-1)
