DAXX (death-associated protein 6)
2009-01-01 Eunhee Kim AffiliationSchool of Bioscience & Biotechnology, Chungnam National University, 220 Goong-dong, Yusung-gu, Daejeon, 305-764, Korea (South)
Identity
HGNC
LOCATION
6p21.32
IMAGE
LOCUSID
ALIAS
BING2,DAP6,EAP1,SMIM40
FUSION GENES
DNA/RNA
Description
Daxx gene has 8 exons on chromosome 6. The sizes of the exons are 66, 256, 832, 212, 214, 475, 223 and 191 bps.
Transcription
2,477 bp mRNA.
Two alternative transcripts:
1. Isoform 1 has been chosen as the canonical sequence
2. Isoform 2 differs from the canonical sequence as follows:
696-740: SSLCIPSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSDPAKNLGRRRSKQDQG
Two alternative transcripts:
1. Isoform 1 has been chosen as the canonical sequence
2. Isoform 2 differs from the canonical sequence as follows:
696-740: SSLCIPSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSDPAKNLGRRRSKQDQG
Proteins
Description
740 amino acids, 82.2 kDa; contains in 3 coiled coils (residues 180-217, 358-399 and 430-489), and 2 nuclear localisation signals (residues 391-395 and 628-634).
Expression
Ubiquitous.
Localisation
Nucleus and cytoplasm.
Note: Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli.
Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres.
Detected in the cytoplasmic punctate structures.
Translocated from the nucleus to the cytoplasm upon glucose deprivation or ischemic stress.
Note: Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli.
Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres.
Detected in the cytoplasmic punctate structures.
Translocated from the nucleus to the cytoplasm upon glucose deprivation or ischemic stress.
Function
Homology
Holomogy with Pan troglodytes (99%); Canis lupus familiaris (89%); Bos taurus (83%); Mus musculus (70%), Rattus norvegicus (73%).
Mutations
Note
Substitutions (see the external links).
Implicated in
Entity name
Disease
Daxx is a component of the promyelocytic leukemia protein (PML) nuclear bodies (NBs).
Entity name
Alpha-thalassemia
Disease
Daxx complex is a novel ATP-dependent chromatin-remodeling complex, with alpha-thalassaemia syndrome protein (ATRX) being the core ATPase subunit and Daxx being the targeting subunit.
Entity name
Leukemia
Disease
Daxx protein was expressed in 38.0% of 50 children with acute leukemia, which was significantly higher than that of the control group (5.0%) (P < 0.05). Daxx expression is abnormal in children with acute leukemia and associated with some clinical features of acute leukemia, suggesting that it may play an important role in the genesis and development of acute leukemia.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 15929099 | 2005 | Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition. | Alkan S et al |
| 11703323 | 2001 | Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17). | Amin HM et al |
| 18456001 | 2008 | Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. | Awasthi YC et al |
| 15302935 | 2004 | Large-scale characterization of HeLa cell nuclear phosphoproteins. | Beausoleil SA et al |
| 14722267 | 2004 | Nuclear localization but not PML protein is required for incorporation of the papillomavirus minor capsid protein L2 into virus-like particles. | Becker KA et al |
| 15359646 | 2004 | In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis. | Boehrer S et al |
| 15683751 | 2005 | Expression of Daxx sensitizes Jurkat T-cells to the apoptosis-inducing effect of chemotherapeutic agents. | Boehrer S et al |
| 15183120 | 2004 | In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. | Brieger A et al |
| 16731959 | 2006 | Human cytomegalovirus (HCMV) UL82 gene product (pp71) relieves hDaxx-mediated repression of HCMV replication. | Cantrell SR et al |
| 11773067 | 2002 | Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules. | Cermák L et al |
| 15637079 | 2005 | Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4. | Chang CC et al |
| 9743501 | 1998 | Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. | Chang HY et al |
| 9990010 | 1999 | Dissecting Fas signaling with an altered-specificity death-domain mutant: requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation. | Chang HY et al |
| 11493600 | 2001 | A kinase-independent function of Ask1 in caspase-independent cell death. | Charette SJ et al |
| 16475184 | 2006 | SUMO regulates the cytoplasmonuclear transport of its target protein Daxx. | Chen A et al |
| 17098929 | 2006 | DAXX interacts with phage PhiC31 integrase and inhibits recombination. | Chen JZ et al |
| 14517282 | 2003 | Daxx silencing sensitizes cells to multiple apoptotic pathways. | Chen LY et al |
| 16638211 | 2006 | [Expression of apoptosis-related proteins in the human bone marrow hematopoietic cells treated by Panax Notoginosides]. | Chen XH et al |
| 18480407 | 2008 | Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis. | Chen YC et al |
| 14761963 | 2004 | Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1. | Cho S et al |
| 12948851 | 2003 | Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. | Chow KU et al |
| 16982744 | 2006 | Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB. | Croxton R et al |
| 12529400 | 2003 | Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. | Ecsedy JA et al |
| 11799127 | 2002 | The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. | Emelyanov AV et al |
| 11716541 | 2001 | Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies. | Engelhardt OG et al |
| 17670833 | 2007 | Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. | Everett RD et al |
| 12033769 | 2002 | Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2. | Florin L et al |
| 11099484 | 2001 | HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism. | Genini D et al |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Gerhard DS et al |
| 11420043 | 2001 | An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons. | Gongora R et al |
| 15339933 | 2004 | The transcriptional repressor hDaxx potentiates p53-dependent apoptosis. | Gostissa M et al |
| 15795247 | 2005 | The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription. | Greger JG et al |
| 17947514 | 2007 | Knockdown of hDaxx in normally non-permissive undifferentiated cells does not permit human cytomegalovirus immediate-early gene expression. | Groves IJ et al |
| 16955392 | 2006 | Gene expression profiling of human synovial sarcoma cell line (Hs701.T) in response to IL-1beta stimulation. | Ha WY et al |
| 9521053 | 1998 | Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. | Herberg JA et al |
| 11992005 | 2002 | Functional interaction between the pp71 protein of human cytomegalovirus and the PML-interacting protein human Daxx. | Hofmann H et al |
| 14678985 | 2003 | HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. | Hofmann TG et al |
| 12140263 | 2002 | Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. | Hollenbach AD et al |
| 17590404 | 2007 | Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells. | Hwang J et al |
| 16038411 | 2005 | C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis. | Hwang JR et al |
| 15781341 | 2005 | Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes. | Ishida N et al |
| 10525530 | 1999 | PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. | Ishov AM et al |
| 15252119 | 2004 | Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX. | Ishov AM et al |
| 12150977 | 2002 | Modification of Daxx by small ubiquitin-related modifier-1. | Jang MS et al |
| 18196534 | 2008 | Critical roles for JNK, c-Jun, and Fas/FasL-Signaling in vitamin E analog-induced apoptosis in human prostate cancer cells. | Jia L et al |
| 18003619 | 2008 | Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death. | Jung YS et al |
| 15983381 | 2005 | Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. | Junn E et al |
| 9740801 | 1998 | Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. | Juo P et al |
| 18242185 | 2008 | Proteasome inhibitor MG132 blocks viral DNA replication and assembly of human cytomegalovirus. | Kaspari M et al |
| 12917339 | 2003 | ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. | Kawai T et al |
| 15861194 | 2005 | Daxx is required for stress-induced cell death and JNK activation. | Khelifi AF et al |
| 12954772 | 2003 | Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML. | Kim EJ et al |
| 16088932 | 2005 | Upregulation of Daxx mediates apoptosis in response to oxidative stress. | Kim KS et al |
| 14637155 | 2003 | Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation. | Kim YY et al |
| 9407001 | 1997 | Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. | Kiriakidou M et al |
| 16810318 | 2006 | Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. | Kitagawa D et al |
| 11495919 | 2001 | Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. | Ko YG et al |
| 16287980 | 2005 | SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. | Kuo HY et al |
| 16524876 | 2006 | BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. | Kwon JE et al |
| 15240113 | 2004 | Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP. | La M et al |
| 11842083 | 2002 | The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1. | Lalioti VS et al |
| 11244500 | 2001 | Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. | Lehembre F et al |
| 16679534 | 2006 | CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus. | Lemos TA et al |
| 17384262 | 2006 | HGF/SF regulates expression of apoptotic genes in MCF-10A human mammary epithelial cells. | Leroy C et al |
| 10669754 | 2000 | Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. | Li H et al |
| 10698492 | 2000 | EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. | Li R et al |
| 11907324 | 2002 | Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx. | Li XD et al |
| 16566946 | 2006 | Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma. | Li XJ et al |
| 17707345 | 2007 | Sensitization to Fas-mediated apoptosis by dengue virus capsid protein. | Limjindaporn T et al |
| 15572661 | 2004 | Negative modulation of androgen receptor transcriptional activity by Daxx. | Lin DY et al |
| 17081986 | 2006 | Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. | Lin DY et al |
| 12595526 | 2003 | Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential. | Lin DY et al |
| 11948183 | 2002 | Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. | Lin DY et al |
| 17404597 | 2007 | Axin bridges Daxx to p53. | Lin SC et al |
| 17471023 | 2007 | Daxx shortens mitotic arrest caused by paclitaxel. | Lindsay CR et al |
| 17306074 | 2007 | [Expression of Daxx in children with acute leukemia]. | Liu J et al |
| 12186918 | 2002 | Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins. | Lopez P et al |
| 11971979 | 2002 | Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. | Lopez P et al |
| 8125298 | 1994 | Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | Maruyama K et al |
| 18264718 | 2008 | Differences between mouse and human cytomegalovirus interactions with their respective hosts at immediate early times of the replication cycle. | Maul GG et al |
| 17360386 | 2007 | Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. | Meinecke I et al |
| 12482920 | 2003 | RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX. | Michaelson JS et al |
| 15087395 | 2004 | Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs. | Mo YY et al |
| 14574404 | 2003 | The DNA sequence and analysis of human chromosome 6. | Mungall AJ et al |
| 16861237 | 2006 | Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx. | Murakami Y et al |
| 16331268 | 2006 | Physical and functional interactions between Daxx and STAT3. | Muromoto R et al |
| 16455055 | 2006 | Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins. | Nery FC et al |
| 17891170 | 2008 | Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. | Nieto-Miguel T et al |
| 12482984 | 2003 | Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53. | Ohiro Y et al |
| 17081983 | 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Olsen JV et al |
| 17362989 | 2007 | Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx. | Park J et al |
| 11483955 | 2001 | TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. | Perlman R et al |
| 9645950 | 1998 | Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. | Pluta AF et al |
| 18094192 | 2008 | Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response. | Poleshko A et al |
| 16603511 | 2006 | Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression. | Preston CM et al |
| 18413714 | 2008 | Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation. | Puto LA et al |
| 14499622 | 2003 | Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. | Reuter TY et al |
| 11034606 | 2000 | FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation. | Rochat-Steiner V et al |
| 17938171 | 2007 | A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx. | Ryo A et al |
| 11112409 | 2000 | Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9. | Ryu SW et al |
| 17596307 | 2007 | Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro. | Saffert RT et al |
| 16406523 | 2006 | Daxx: death or survival protein? | Salomoni P et al |
| 18069800 | 2008 | 4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. | Sharma R et al |
| 18031230 | 2007 | Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization. | Shih HM et al |
| 15998799 | 2005 | Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop. | Song JJ et al |
| 11881150 | 2001 | [Monoclonal antibodies against protein Daxx and its localization in nuclear domains 10]. | Sotnikov AG et al |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL et al |
| 17370120 | 2007 | Anti-apoptotic effects of probucol are associated with downregulation of Daxx expression in THP-1 macrophage. | Su B et al |
| 9373149 | 1997 | Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. | Suzuki Y et al |
| 15077145 | 2004 | PML nuclear bodies and apoptosis. | Takahashi Y et al |
| 15878163 | 2005 | The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62. | Tang J et al |
| 14990586 | 2004 | A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. | Tang J et al |
| 17942542 | 2008 | Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection. | Tavalai N et al |
| 10545115 | 1999 | Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs). | Torii S et al |
| 18200667 | 2008 | Effect of Daxx on cholesterol accumulation in hepatic cells. | Tuo QH et al |
| 16569639 | 2006 | Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells. | Tzeng SL et al |
| 10903735 | 2000 | Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD. | Villunger A et al |
| 17035242 | 2006 | Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter. | Woodhall DL et al |
| 12407442 | 2002 | Ultraviolet radiation-induced apoptosis is mediated by Daxx. | Wu S et al |
| 12953102 | 2003 | The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. | Xue Y et al |
| 9215629 | 1997 | Daxx, a novel Fas-binding protein that activates JNK and apoptosis. | Yang X et al |
| 12086872 | 2002 | Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. | Yeoh EJ et al |
| 17661348 | 2008 | Daxx contains two nuclear localization signals and interacts with importin alpha3. | Yeung PL et al |
| 14557665 | 2003 | Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx. | Zhao LY et al |
| 10684855 | 2000 | Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. | Zhong S et al |
| 17389020 | 2007 | Sequence variation within the major histocompatibility complex subregion centromeric of HLA class II in type 1 diabetes. | van der Slik AR et al |
Other Information
Locus ID:
NCBI: 1616
MIM: 603186
HGNC: 2681
Ensembl: ENSG00000204209
Variants:
dbSNP: 1616
ClinVar: 1616
TCGA: ENSG00000204209
COSMIC: DAXX
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38038252 | 2024 | DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks. | 0 |
| 38038252 | 2024 | DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks. | 0 |
| 35691289 | 2023 | DAXX, ATRX, and MSI in PanNET and Their Metastases: Correlation with Histopathological Data and Prognosis. | 0 |
| 36868228 | 2023 | DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network. | 18 |
| 37396746 | 2023 | The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death-Domain Associated Protein (DAXX) in Breast Carcinoma Tissues. | 0 |
| 37871853 | 2023 | HPV16 E7 protein antagonizes TNF-α-induced apoptosis of cervical cancer cells via Daxx/JNK pathway. | 1 |
| 35691289 | 2023 | DAXX, ATRX, and MSI in PanNET and Their Metastases: Correlation with Histopathological Data and Prognosis. | 0 |
| 36868228 | 2023 | DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network. | 18 |
| 37396746 | 2023 | The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death-Domain Associated Protein (DAXX) in Breast Carcinoma Tissues. | 0 |
| 37871853 | 2023 | HPV16 E7 protein antagonizes TNF-α-induced apoptosis of cervical cancer cells via Daxx/JNK pathway. | 1 |
| 35718818 | 2022 | Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth. | 5 |
| 36162510 | 2022 | Death domain-associated protein DAXX regulates noncoding RNA transcription at the centromere through the transcription regulator ZFAT. | 1 |
| 35718818 | 2022 | Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth. | 5 |
| 36162510 | 2022 | Death domain-associated protein DAXX regulates noncoding RNA transcription at the centromere through the transcription regulator ZFAT. | 1 |
| 32694250 | 2021 | Direct Interaction of Daxx and Androgen Receptor Is Required for Their Regulatory Activity in Cholesterol Biosynthesis. | 3 |
Citation
Eunhee Kim
DAXX (death-associated protein 6)
Atlas Genet Cytogenet Oncol Haematol. 2009-01-01
Online version: http://atlasgeneticsoncology.org/gene/40265/daxx-(death-associated-protein-6)
