Institute of Life Sciences, Bhubaneswar, Odisha 751023, India (BD, SSu, SJ, SSe); Apollo Hospital, Bhubaneswar, Odisha 751003, India (MRB)
In the year 1991 Van der Bruggen P et al. cloned and named MAGE-1 gene that encodes MZ2E antigen, which is expressed in melanoma tissues and cell lines (van der Bruggen et al., 1991). Since then based on sequence similarity MAGE family has expanded to more than 60 genes (Chomez et al., 2001). According to their chromosomal location and tissue-specific expression pattern, all the members of this family are categorized into two groups; type I (cancer and testis specific) and type II (ubiquitous) MAGE. MAGEA sub-family has 12 members starting from MAGEA1 to MAGEA12, among them MAGEA7 is a pseudo-gene (Doyle et al., 2010). The current review summarizes the information specifically on MAGEA3s DNA\/RNA, protein structure, function and where the gene is implicated.
Regulation Till now demethylation of promoter region has been reported as the major regulatory mechanism that leads to unusual derepression of MAGEA3 in cancer cells (Figure 2). Histone acetylation is also reported to regulate the expression of MAGEA3 in cancer cells (Kim et al., 2006b; Wischnewski et al., 2006).The MAGEA3 promoter is found to be hypermethylated in response to FGFR2-IIIb and/or FGF7 stimulating signals resulting into MAGEA3 silencing in MAGEA3-positive thyroid cancer cell lines (Kondo et al., 2007). MBD1, a methyl-CpG Binding Domain protein is reported to have the ability to bind the unmethylated promoter of MAGEA3 and suppresses the promoter activity that cannot be retracted by Ets-1 transcription factor (Wischnewski et al., 2007).
NCBI: 4102 MIM: 300174 HGNC: 6801 Ensembl: ENSG00000221867
dbSNP: 4102 ClinVar: 4102 TCGA: ENSG00000221867 COSMIC: MAGEA3
Biswajit Das ; Sujit Suklabaidya ; Sumeet Jain ; Manas R Baisakh ; Shantibhusan Senapati
MAGEA3 (melanoma antigen family A, 3)
Atlas Genet Cytogenet Oncol Haematol. 2014-04-01
Online version: http://atlasgeneticsoncology.org/gene/41247
