DYRK1B (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B)
2008-05-01 Eileen Friedman AffiliationUpstate Medical University, State University of New York, Syracuse, New York 13210, USA
DNA/RNA
Description
11 exons and 10 introns encompassing 8.8kb.
Transcription
Start at exon 1 encodes major active form p69, with alternative splicing in exon 9 giving rise to kinase inactive p62, and with alternative splicing within intron 1-2 giving rise to p75 in skeletal muscle.
Pseudogene
None reported
Proteins
Note
Serine/threonine kinase activated by intramolecular phosphorylation on tyrosine.
Description
629 amino acids.
Expression
Widely expressed at low levels, with elevated expression in muscle and testis.
Function
Mediates myoblast differentiation.
Mutations
Note
None in SW480 colon cancer cells, none reported.
Implicated in
Entity name
Ductal adenocarcinoma of the pancreas
Note
Active kinase in pancreatic cancer cell lines.
Disease
Present in 89% of cases by immunocytochemistry (25 of 28 cases)
Cytogenetics
19q13 amplicon in 10% of cases
Hybrid gene
None reported
Fusion protein
None reported
Oncogenesis
Embryonic knockout is viable and has no reported phenotype
Entity name
Rhabdomyosarcoma
Note
Overexpressed in 12 of 16 cases; active kinase in rhabdomyosarcoma cell lines
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 16618736 | 2006 | The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. | Deng X et al |
| 17671193 | 2007 | The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer. | Jin K et al |
| 10910078 | 2000 | Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. | Lee K et al |
| 16707437 | 2006 | Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas. | Mercer SE et al |
Other Information
Locus ID:
NCBI: 9149
MIM: 604556
HGNC: 3092
Ensembl: ENSG00000105204
Variants:
dbSNP: 9149
ClinVar: 9149
TCGA: ENSG00000105204
COSMIC: DYRK1B
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38040123 | 2024 | Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance. | 1 |
| 38170957 | 2024 | Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes. | 1 |
| 38040123 | 2024 | Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance. | 1 |
| 38170957 | 2024 | Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes. | 1 |
| 34969768 | 2022 | Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells. | 1 |
| 35165364 | 2022 | Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B. | 3 |
| 35235343 | 2022 | DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics. | 42 |
| 36318489 | 2022 | Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis. | 2 |
| 34969768 | 2022 | Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells. | 1 |
| 35165364 | 2022 | Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B. | 3 |
| 35235343 | 2022 | DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics. | 42 |
| 36318489 | 2022 | Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis. | 2 |
| 34291393 | 2021 | Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians. | 1 |
| 34291393 | 2021 | Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians. | 1 |
| 32611815 | 2020 | Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin. | 6 |
Citation
Eileen Friedman
DYRK1B (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B)
Atlas Genet Cytogenet Oncol Haematol. 2008-05-01
Online version: http://atlasgeneticsoncology.org/gene/43235/dyrk1b-(dual-specificity-tyrosine-(y)-phosphorylation-regulated-kinase-1b)
