DYRK1B (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B)

2008-05-01 Eileen Friedman Affiliation

Upstate Medical University, State University of New York, Syracuse, New York 13210, USA

Identity

HGNC

DYRK1B

LOCATION

19q13.2

LOCUSID

9149

ALIAS

AOMS3,MIRK

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

11 exons and 10 introns encompassing 8.8kb.

Transcription

Start at exon 1 encodes major active form p69, with alternative splicing in exon 9 giving rise to kinase inactive p62, and with alternative splicing within intron 1-2 giving rise to p75 in skeletal muscle.

Pseudogene

None reported

Proteins

Note

Serine/threonine kinase activated by intramolecular phosphorylation on tyrosine.

Description

629 amino acids.

Expression

Widely expressed at low levels, with elevated expression in muscle and testis.

Function

Mediates myoblast differentiation.

Mutations

Note

None in SW480 colon cancer cells, none reported.

Implicated in

Entity name

Ductal adenocarcinoma of the pancreas

Note

Active kinase in pancreatic cancer cell lines.

Disease

Present in 89% of cases by immunocytochemistry (25 of 28 cases)

Cytogenetics

19q13 amplicon in 10% of cases

Hybrid gene

None reported

Fusion protein

None reported

Oncogenesis

Embryonic knockout is viable and has no reported phenotype

Entity name

Rhabdomyosarcoma

Note

Overexpressed in 12 of 16 cases; active kinase in rhabdomyosarcoma cell lines

Bibliography

Pubmed ID	Last Year	Title	Authors
16618736	2006	The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma.	Deng X et al
17671193	2007	The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.	Jin K et al
10910078	2000	Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.	Lee K et al
16707437	2006	Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas.	Mercer SE et al

Other Information

Locus ID:

NCBI: 9149
MIM: 604556
HGNC: 3092
Ensembl: ENSG00000105204

Variants:

dbSNP: 9149
ClinVar: 9149
TCGA: ENSG00000105204
COSMIC: DYRK1B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105204	ENST00000323039	Q9Y463
ENSG00000105204	ENST00000323039	A0A024R0I0
ENSG00000105204	ENST00000348817	Q9Y463
ENSG00000105204	ENST00000348817	A0A024R0M8
ENSG00000105204	ENST00000430012	Q9Y463
ENSG00000105204	ENST00000430012	A0A024R0J6
ENSG00000105204	ENST00000593685	Q9Y463
ENSG00000105204	ENST00000593685	A0A024R0I0
ENSG00000105204	ENST00000597639	Q9Y463
ENSG00000105204	ENST00000597639	A0A024R0M8
ENSG00000105204	ENST00000600611	M0R131
ENSG00000105204	ENST00000601972	M0R2X3

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20512148	2010	DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.	62
19351855	2009	Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species.	38
24827035	2014	A form of the metabolic syndrome associated with mutations in DYRK1B.	34
15851482	2005	Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts.	33
11980910	2002	Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.	26
16845176	2006	Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival.	26
19542220	2009	Mirk regulates the exit of colon cancer cells from quiescence.	25
18818203	2008	G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation.	24
16618736	2006	The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma.	21
17046823	2006	Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells.	17

Citation

Eileen Friedman

DYRK1B (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/43235/dyrk1b-(dual-specificity-tyrosine-(y)-phosphorylation-regulated-kinase-1b)