Identity
HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
ACDCR1,CGI-45,CGI45,PAQR1,TESBP1A
FUSION GENES
DNA/RNA
Genomic structure of ADIPOR1. Blue boxes indicate exons.
Description
Eight exons spanning 17.5 kb. Transcription is from telomere to centromere.
Transcription
Transcription produces 11 different mRNAs, 10 alternatively spliced variants and 1 unspliced form. There are 6 probable alternative promoters, 2 non overlapping alternative last exons and 8 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5 end, truncation of the 3 end, presence or absence of 6 cassette exons, overlapping exons with different boundaries. 9 spliced and the unspliced mRNAs putatively encode good proteins, altogether 9 different isoforms (3 complete, 6 partial), some containing Hly-III related proteins domain (Pfam) some transmembrane domains (Psort2); 1 of the 3 complete proteins appears to be secreted. The remaining mRNA variant (spliced) appears not to encode a good protein.
Proteins
Description
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that counteracts the effects of insulin.
Expression
Widely expressed. Highly expressed in adipose tissue and skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. We have also shown expression in normal and cancerous breast tissue as well as in other cancers such as prostate, colon, endometrial. It is also present in several cell lines.
Localisation
ADIPOR1 localizes to the plasma membrane.
Function
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARa ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity for globular adiponectin but low-affinity for full-length adiponectin.
Homology
The mouse, human, and rat Adipor1 protein (ADIPOR1) contains 375 amino acids. Human and mouse ADIPOR1 share 96.8% identity.
Mutations
Note
One functional polymorphism has been described. Rs7539542 has been found to modulate expression of ADIPOR1 mRNA (Soccio et al., 2006).
Implicated in
Entity name
Breast Cancer
Note
Adiponectin has been implicated in breast cancer. The breast cancer cell lines MCF-7, MDB-MB-231 and T47D were found to express both adiponectin receptors ADIPOR1/ADIPOR2 (Dieudonne et al., 2006; Korner et al., 2007) and exposure of T47D cells to adiponectin, significantly inhibited their proliferation (Korner et al., 2007). rs2232853 CT genotype (OR=1.67; 95% CI 1.23-2.26) and the combination of rs7539542 GC (OR=0.59; 95% CI 0.36-0.98) and CC genotypes (OR=0.57; 95% CI 0.35-0.94) were significantly associated with breast cancer risk. The high expressing rs2241766 G allele (GG and GT genotypes) was associated with decreased breast cancer risk (OR=0.64; 95% CI 0.49-0.83). The low expressing rs1501299 G allele was associated with increased breast cancer risk: for TG: OR=1.59; 95% CI 1.03-2.48, for GG: OR= 1.80; 95% CI 1.14-2.85.
Entity name
Colon Cancer
Note
Adiponectin has also been implicated in colon cancer risk. rs266729 polymorphism was significantly associated with colon cancer risk: the RR for the GG/CG genotypes was rs266729 was associated with a reduced colorectal cancer risk: O.R. 0.73, 95% CI (0.53-0.99) (Kaklamani et al., 2008).
Entity name
Endometrial Cancer
Note
Adiponectin levels have been shown to correlate with endometrial cancer risk (Petridou et al., 2003; Dal et al., 2004).
Entity name
Prostate Cancer
Note
Adiponectin levels have been shown to correlate with prostate cancer risk (Barb et al., 2007; Arisan et al., 2009).
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 19322011 | 2009 | Serum adipocytokine levels in prostate cancer patients. | Arisan ED et al |
| 18265479 | 2007 | Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. | Barb D et al |
| 15001602 | 2004 | Circulating adiponectin and endometrial cancer risk. | Dal Maso L et al |
| 16678125 | 2006 | Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. | Dieudonne MN et al |
| 18827209 | 2008 | Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. | Kaklamani VG et al |
| 17192291 | 2007 | Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies. | Körner A et al |
| 12629074 | 2003 | Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece. | Petridou E et al |
| 17003341 | 2006 | Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. | Soccio T et al |
Other Information
Locus ID:
NCBI: 51094
MIM: 607945
HGNC: 24040
Ensembl: ENSG00000159346
Variants:
dbSNP: 51094
ClinVar: 51094
TCGA: ENSG00000159346
COSMIC: ADIPOR1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000159346 | ENST00000340990 | Q96A54 |
| ENSG00000159346 | ENST00000367254 | F8W782 |
| ENSG00000159346 | ENST00000417068 | C9JNM5 |
| ENSG00000159346 | ENST00000426229 | C9J0W7 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38063230 | 2024 | Overexpression of salusin‑β downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells. | 1 |
| 38063230 | 2024 | Overexpression of salusin‑β downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells. | 1 |
| 35733794 | 2022 | AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway. | 6 |
| 36429712 | 2022 | Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings. | 1 |
| 36527105 | 2022 | Circulating adiponectin levels, expression of adiponectin receptors, and methylation of adiponectin gene promoter in relation to Alzheimer's disease. | 3 |
| 35733794 | 2022 | AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway. | 6 |
| 36429712 | 2022 | Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings. | 1 |
| 36527105 | 2022 | Circulating adiponectin levels, expression of adiponectin receptors, and methylation of adiponectin gene promoter in relation to Alzheimer's disease. | 3 |
| 33555532 | 2021 | From diabetes to renal aging: the therapeutic potential of adiponectin. | 3 |
| 33562295 | 2021 | Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects. | 10 |
| 33851685 | 2021 | The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia. | 0 |
| 33555532 | 2021 | From diabetes to renal aging: the therapeutic potential of adiponectin. | 3 |
| 33562295 | 2021 | Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects. | 10 |
| 33851685 | 2021 | The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia. | 0 |
| 32000405 | 2020 | Adiponectin receptor 1 gene is potentially associated with severity of postoperative pain but not cancer pain. | 2 |
Citation
Virginia Kaklamani ; Christos Mantzoros
ADIPOR1 (adiponectin receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2009-05-01
Online version: http://atlasgeneticsoncology.org/gene/44512/adipor1
