LIN28B (lin-28 homolog B (C. elegans))

2011-07-01   Yung-Ming Jeng  

Department of Biochemistry, Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan

Identity

HGNC
LIN28B
LOCATION
6q16.3
LOCUSID
389421
ALIAS
CSDD2
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

The gene spans over 125 kb on plus strand; 4 exons.

Transcription

The gene is mainly expressed in fetal tissues and not expressed in adult tissue and reexpressed in cancer tissue.

Proteins

Description

Lin28B is an oncofetal RNA-binding protein. Lin-28B protein consists of two domains that contain RNA-binding motif: the N-terminal cold shock domain and a pair of retroviral-type CCHC zinc fingers. It inhibits biosynthesis of let-7 microRNA through binding to the 5-GGAG-3 motif in the terminal loop of pre-let-7 and promoting terminal uridylation of let-7 precusor by TUTase4. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation.

Expression

Cytoplasm.

Function

It inhibits biosynthesis of let-7 microRNA through promoting terminal uridylation of let-7 precusor by TUTase4.

Homology

Lin28

Mutations

Note

No somatic mutation of Lin28B was identified in cancer.

Implicated in

Entity name
Hepatocellular carcinoma
Note
Lin28B expression is more frequently noted in high-grade hepatocellular carcinoma with high alpha-fetoprotein levels. Knockdown of Lin28B by RNA interference in the HCC cell line suppressed proliferation in vitro and reduced in vivo tumor growth in NOD/SCID mice. In contrast, overexpression of Lin28B in the HCC cell line enhanced tumorigenicity. Overexpression of Lin28B also induced epithelial-mesenchymal transition in HA22T cells and hence, invasion capacity.
Entity name
Colorectal cancer
Note
Lin28B is overexpressed in colorectal cancer. It promotes cell migration, invasion and transforms immortalized colonic epithelial cells. In addition, constitutive LIN28B expression increases expression of intestinal stem cell markers LGR5 and PROM1 in the presence of let-7 restoration.
Entity name
Ovarian cancer
Note
Lin28B is overexpressed in high grade serous ovarian cancer. Pleomorphism in Lin28B promoter region is associated with susceptibility to epithelium ovarian cancer. Patients with high Lin28B ovarian cancer had shorter progression-free and overall survival than those with low Lin28B ovarian cancer.
Entity name
Age at menarche
Note
A sequence variation in Lin28B is identified as the SNP most significant associated with age at menarche in one genome wide study. Besides, a meta-analysis of 32 genome-wide association studies in 87802 women found polymorphism of Lin28B is strongly associated with age at menarche. Knockout mice of Lin28B also show delay in puberty onset.
Entity name
Body height
Note
A LIN28B SNP, rs314277, is associated with final body height.

Article Bibliography

Pubmed IDLast YearTitleAuthors
194486212009Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.He C et al
215332842011Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.Helland Å et al
189510942008Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.Heo I et al
215121362011LIN28B promotes colon cancer progression and metastasis.King CE et al
216252102011LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms.King CE et al
194776332009Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II.Lu L et al
194836832009Lin28 promotes transformation and is associated with advanced human malignancies.Viswanathan SR et al

Other Information

Locus ID:

NCBI: 389421
MIM: 611044
HGNC: 32207
Ensembl: ENSG00000187772

Variants:

dbSNP: 389421
ClinVar: 389421
TCGA: ENSG00000187772
COSMIC: LIN28B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187772ENST00000345080Q6ZN17
ENSG00000187772ENST00000635857A0A1B0GTK2
ENSG00000187772ENST00000637759A0A1B0GVD3

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382169642024Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28.2
383052852024MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and Proliferation of Hepatocellular Carcinoma Cells.0
383211062024LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression.0
383388812024A Multi-Omics Approach Reveals Enrichment in Metabolites Involved in the Regulation of the Glutathione Pathway in LIN28B-Dependent Cancer Cells.0
386123952024Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.0
387044542024Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6.0
382169642024Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28.2
383052852024MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and Proliferation of Hepatocellular Carcinoma Cells.0
383211062024LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression.0
383388812024A Multi-Omics Approach Reveals Enrichment in Metabolites Involved in the Regulation of the Glutathione Pathway in LIN28B-Dependent Cancer Cells.0
386123952024Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.0
387044542024Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6.0
366493082023LIN28 expression and function in medulloblastoma.2
366607962023Semaphorin 3A inhibits tumor progression via the downregulation of Lin28B in ovarian cancer.1
368283042023Association of the KISS1, LIN28B, VDR and ERα gene polymorphisms with early and fast puberty in Chinese girls.0

Citation

Yung-Ming Jeng

LIN28B (lin-28 homolog B (C. elegans))

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/45723/tumors-explorer/cancer-prone-explorer/js/template.js