HPSE2 (heparanase 2 (inactive))

2007-02-01  

Identity

HGNC
HPSE2
LOCATION
10q24.2
LOCUSID
60495
ALIAS
HPA2,HPR2,UFS,UFS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 60495
MIM: 613469
HGNC: 18374
Ensembl: ENSG00000172987

Variants:

dbSNP: 60495
ClinVar: 60495
TCGA: ENSG00000172987
COSMIC: HPSE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172987ENST00000370546Q8WWQ2
ENSG00000172987ENST00000370549Q8WWQ2
ENSG00000172987ENST00000370552Q8WWQ2
ENSG00000172987ENST00000404542A0A0A0MSB9
ENSG00000172987ENST00000614306A0A087X238
ENSG00000172987ENST00000628193Q8WWQ2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosaminoglycan degradationKEGGko00531
Glycosaminoglycan degradationKEGGhsa00531
Metabolic pathwaysKEGGhsa01100
Heparan sulfate degradationKEGGhsa_M00078
Heparan sulfate degradationKEGGM00078
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG degradationREACTOMER-HSA-2024096

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385194562024Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis.0
389902082024Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome.0
385194562024Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis.0
389902082024Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome.0
369802542023Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma.0
369802542023Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma.0
348083352022Induction of heparanase 2 (Hpa2) expression by stress is mediated by ATF3.5
361228212022Heparanase 2 (Hpa2) attenuates the growth of human sarcoma.4
348083352022Induction of heparanase 2 (Hpa2) expression by stress is mediated by ATF3.5
361228212022Heparanase 2 (Hpa2) attenuates the growth of human sarcoma.4
336635222021Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis.9
338392212021Heparanase 2 (Hpa2) attenuates the growth of pancreatic carcinoma.7
340043532021Heparanase 2 (Hpa2) attenuates tumor growth by inducing Sox2 expression.9
343438222021Role of heparanase 2 (Hpa2) in gastric cancer.6
336635222021Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis.9

Citation

Dessen P

HPSE2 (heparanase 2 (inactive))

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46219/favicon/welcome