Department of Otolaryngology Head, Neck Surgery, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-8509, Japan
Maruzela et al. defined a detailed expression status for MAL protein by immunostaining in a wide range of human tissues and expression is found to be mainly localized in epithelial cells, myelinating cells and T-lymphocytes (Marazuela et al., 2003). Detailed results according to this study:
A- MAL negative cells and tissues:
- Fibroblasts, endothelial cells, B lymphocytes, skeletal and smooth muscle, skin (keratinized squamous epithelium and subcutaneous fibro-adipose tissue).
B- MAL positive cells and tissues:
- Gastrointestinal tract: Epithelium in esophagus, stomach, ileum, colon, liver, and pancreas.
- Genitourinary tract: Multiple sites of tract including transitional epithelium of the urothelium.
- Respiratory tract: Ciliated columnar epithelium of bronchi and bronchioles, and type 2 pneumocytes of alveolae.
- Hematopoietic system: Expression is restricted to regions rich in T-cells including cortex of thymus and paracortical lymphocytes of lymph node and tonsil.
- Endocrine system: Thyroid follicular cells, medulla of adrenal gland.
- Nervous system: Axons of peripheral nerves and myelinating Schwann cells in peripheral nervous system, oligodendrocytes of white and gray matter in central nervous system.
- Exocrine glands: breast epithelium (Horne et al., 2009).
Levent B Beder ; Noboru Yamanaka
MAL (mal, T-cell differentiation protein)
Atlas Genet Cytogenet Oncol Haematol. 2010-07-01
Online version: http://atlasgeneticsoncology.org/gene/46222/mal