Formin-like 1 (FMNL1) is a member of the Formin protein family, which are regulators of actin and microtubule cytoskeletal dynamics. FMNL1 belongs to the subfamily of formins knows as Diaphanous-related formins (DRF) and is involved in processes such as phagocytosis, cell adhesion, podosome dynamics, cell migration, cytokinesis, and polarity control. It has been suggested that spatial and temporal regulation of FMNL1 is controlled by small Rho GTPases. The present review contains data on FMNL1 DNA\/RNA, protein encoded and function.
Table 1. Comparative identity of human FMNL1 with other species
Protein
DNA
99.0
98.0
96.0
95.0
94.0
88.0
93.0
86.0
85.0
91.0
87.0
89.0
84.0
72.0
69.0
82.0
NCBI: 752 MIM: 604656 HGNC: 1212 Ensembl: ENSG00000184922
dbSNP: 752 ClinVar: 752 TCGA: ENSG00000184922 COSMIC: FMNL1
Matheus Rodrigues Lopes ; Patricia Favaro
FMNL1 (formin like 1)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/46313/gene-fusions-explorer/welcome