SLC39A1 (solute carrier family 39 (zinc transporter), member 1)
2011-10-01 Renty B Franklin , Leslie C Costello AffiliationDepartment of Oncology, Diagnostic Sciences, Dental School, The Greenebaum Cancer Center, University of Maryland, Baltimore, MD, 21201, USA
DNA/RNA
Description
The SLC39A1 gene contains 5 exons, three of which are coding. The length of the gene is 8600 base pairs according to the Entrez Gene database. Several transcripts have been reported containing either 3, 4, or 5 exons. However, the coding sequence for SLC39A1 is the same for all reported transcripts.
Transcription
Only a single isoform has been reported; mRNA 2445 bases in length; coding region of 975 bases.
Pseudogene
None reported.
Proteins
Description
SLC39A1 encodes Zrt/Irt-like protein family member 1 (ZIP1).
ZIP1 is a 35 kDa molecular weight protein consisting of 324 amino acids. The protein contains 8 transmembrane spanning domains and shows the characteristics of a zinc transporter (Gaither and Eide, 2001).
ZIP1 is a 35 kDa molecular weight protein consisting of 324 amino acids. The protein contains 8 transmembrane spanning domains and shows the characteristics of a zinc transporter (Gaither and Eide, 2001).
Expression
ZIP1 is ubiquitously expressed in mammalian cells (Gaither and Eide, 2001). Expression is down regulated in prostate malignancy (Franklin et al., 2005). Its constitutive expression is reported to be regulated by SP and CREB1 (Makhov et al., 2009). Down regulation of expression in prostate malignancy is reported due to transcription repression by ras response element binding protein-1 (RREB-1) (Milon et al., 2010).
Localisation
ZIP1 is located at the cell membrane.
Function
ZIP1 is a facilitated zinc uptake transporter (Franklin et al., 2003). Activity of the transporter results in the intracellular accumulation of zinc. ZIP1 is involved in apoptosis induction in prostate cancer cells.
Homology
Mus musculus Slc39a1; Rattus norvegicus Slc39a1; Bos taurus Slc39a1; Danio rerio slc39a1.
Mutations
Note
No diseases related to mutation are reported.
Implicated in
Entity name
Prostate cancer
Note
SLC39A1 is down regulated in prostate cancer (Franklin et al., 2005). Knockdown of the SLC39A1 expression decreases cellular zinc and increases growth of PC-3 cells (Franklin et al., 2003). Over expression of SLC39A1 inhibits prostate tumor growth in a xenograft model (Golovine et al., 2008).
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 16153295 | 2005 | hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. | Franklin RB et al |
| 11301334 | 2001 | The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. | Gaither LA et al |
| 18765529 | 2008 | Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo. | Golovine K et al |
| 19026724 | 2009 | Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells. | Makhov P et al |
| 19802870 | 2010 | Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells. | Milon BC et al |
Other Information
Locus ID:
NCBI: 27173
MIM: 604740
HGNC: 12876
Ensembl: ENSG00000143570
Variants:
dbSNP: 27173
ClinVar: 27173
TCGA: ENSG00000143570
COSMIC: SLC39A1
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34615436 | 2021 | Decreased SLC39A1 (Solute carrier family 39 member 1) expression predicts unfavorable prognosis in patients with early-stage hepatocellular carcinoma. | 2 |
| 34615436 | 2021 | Decreased SLC39A1 (Solute carrier family 39 member 1) expression predicts unfavorable prognosis in patients with early-stage hepatocellular carcinoma. | 2 |
| 30581142 | 2019 | Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System. | 57 |
| 30581142 | 2019 | Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System. | 57 |
| 26081940 | 2015 | Persistent low expression of hZip1 in mucinous carcinomas of the ovary, colon, stomach and lung. | 11 |
| 26081940 | 2015 | Persistent low expression of hZip1 in mucinous carcinomas of the ovary, colon, stomach and lung. | 11 |
| 24488210 | 2014 | The alteration of zinc transporter gene expression is associated with inflammatory markers in obese women. | 20 |
| 24878177 | 2014 | hZIP1 that is down-regulated in clear cell renal cell carcinoma is negatively associated with the malignant potential of the tumor. | 10 |
| 24922175 | 2014 | Zinc fortification decreases ZIP1 gene expression of some adolescent females with appropriate plasma zinc levels. | 6 |
| 24488210 | 2014 | The alteration of zinc transporter gene expression is associated with inflammatory markers in obese women. | 20 |
| 24878177 | 2014 | hZIP1 that is down-regulated in clear cell renal cell carcinoma is negatively associated with the malignant potential of the tumor. | 10 |
| 24922175 | 2014 | Zinc fortification decreases ZIP1 gene expression of some adolescent females with appropriate plasma zinc levels. | 6 |
| 23839533 | 2013 | Effects of exogenous zinc on cell cycle, apoptosis and viability of MDAMB231, HepG2 and 293 T cells. | 8 |
| 23921484 | 2013 | Zip1, Zip2, and Zip8 mRNA expressions were associated with growth hormone level during the growth hormone provocation test in children with short stature. | 6 |
| 23839533 | 2013 | Effects of exogenous zinc on cell cycle, apoptosis and viability of MDAMB231, HepG2 and 293 T cells. | 8 |
Citation
Renty B Franklin ; Leslie C Costello
SLC39A1 (solute carrier family 39 (zinc transporter), member 1)
Atlas Genet Cytogenet Oncol Haematol. 2011-10-01
Online version: http://atlasgeneticsoncology.org/gene/46571/slc39a1-(solute-carrier-family-39-(zinc-transporter)-member-1)
