The RREB1 gene is 144384 bp. The mRNA is 8568 bp and codes a protein of 1742 amino acids. Nine splice variants of RREB1 are predicted. Variant 1 contains 13 coding exons.

Five isoforms of RREB1 designated RREB1 alpha, RREB1 beta, RREB1 delta, RREB1 gamma and RREB1 epsilon are expressed through alternative splicing.

None reported.

RREB1 is a zinc finger nuclear protein of 1742 amino acids that contains 15 zinc fingers of the C2H2 type and belongs to the Krueppel zinc-finger protein family. RREB1 protein-protein interactions include NEUROD1 (Ray et al., 2003) and AR (Mukhopadhyay et al., 2007).

RREB1 is ubiquitously expressed in most tissues; however, it may not be expressed in brain.

RREB1 expression is localized to nucleus speckle (Date et al., 2004; Fujimoto-Nishiyama et al., 1997).

RREB1 binds specifically to the ras-responsive element (RRE) of genes to activate promoter activity and gene transcription. It is involved in regulation of calcitonin expression (Thiagalingam et al., 1996). RREB1 is reported to both activate and repress transcription (Chen et al., 2010). RREB1 reportedly negatively regulates the transcriptional activity of the androgen receptor (Mukhopadhyay et al., 2007). RREB1 is reported to play a role in cell to cell adhesion and regulation of cell movement (Melani et al., 2008). The specific roles of the individual spliced forms are not well defined. RREB1 alpha is not required for proliferation of bladder cancer lines; however, RREB1 beta may be required (Nitz et al., 2011).

With members of the Krueppel family of zinc finger proteins.

No disease related mutations are reported.