Evolution des Regulations Endocriniennes, CNRS, UMR7221, Museum National dHistoire Naturelle, Paris, France
DLX6 belongs to the six-member family of DLX genes characterized by a homeobox related to that found in the insect Distal-less (Dll) gene. The six DLX genes are organized as three bigenic pairs with a tail-to-tail orientation (Zerucha et al., 2000), and located on chromosomes where HOX clusters are also found (DLX5\/DLX6; 7q21.3, syntenic to the HOXA cluster), (DLX1\/DLX2; 2q32 syntenic to the HOXD cluster) and (DLX3\/DLX4; 17q21.33 syntenic to the HOXB cluster). During embryonic development DLX genes are involved in the control of appendage and craniofacial morphogenesis and in the differentiation of reproductive organs; in the adult they play a role in bone homeostasis and in the maintenance of tissue integrity.
NCBI: 1750 MIM: 600030 HGNC: 2919 Ensembl: ENSG00000006377
dbSNP: 1750 ClinVar: 1750 TCGA: ENSG00000006377 COSMIC: DLX6
Yorick Gitton ; Giovanni Levi
DLX6 (distal-less homeobox 6)
Atlas Genet Cytogenet Oncol Haematol. 2014-03-01
Online version: http://atlasgeneticsoncology.org/gene/52195/js/lib/popper.js