Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51421
MIM: 614658
HGNC: 17812
Ensembl: ENSG00000114019
Variants:
dbSNP: 51421
ClinVar: 51421
TCGA: ENSG00000114019
COSMIC: AMOTL2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Tight junction | KEGG | ko04530 |
| Tight junction | KEGG | hsa04530 |
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Hippo | REACTOME | R-HSA-2028269 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34165350 | 2022 | AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches. | 6 |
| 34165350 | 2022 | AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches. | 6 |
| 32950569 | 2021 | AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells. | 10 |
| 34036399 | 2021 | AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization. | 3 |
| 34404733 | 2021 | AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation. | 1 |
| 32950569 | 2021 | AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells. | 10 |
| 34036399 | 2021 | AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization. | 3 |
| 34404733 | 2021 | AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation. | 1 |
| 30794467 | 2019 | IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment. | 6 |
| 30794467 | 2019 | IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment. | 6 |
| 28368415 | 2017 | Angiomotin-like 2 interacts with and negatively regulates AKT. | 7 |
| 28368415 | 2017 | Angiomotin-like 2 interacts with and negatively regulates AKT. | 7 |
| 26598551 | 2016 | Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. | 34 |
| 26598551 | 2016 | Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. | 34 |
| 25998128 | 2015 | Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness. | 56 |
Citation
Dessen P
AMOTL2 (angiomotin like 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-04-01
Online version: http://atlasgeneticsoncology.org/gene/53853/amotl2-(angiomotin-like-2)
