USP46 (ubiquitin specific peptidase 46)

2014-08-01  

Identity

HGNC
USP46
LOCATION
4q12
LOCUSID
64854
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64854
MIM: 612849
HGNC: 20075
Ensembl: ENSG00000109189

Variants:

dbSNP: 64854
ClinVar: 64854
TCGA: ENSG00000109189
COSMIC: USP46

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109189ENST00000441222P62068
ENSG00000109189ENST00000451218H7BZK6
ENSG00000109189ENST00000503060D6R9Z4
ENSG00000109189ENST00000508499P62068
ENSG00000109189ENST00000512656D6RIX7
ENSG00000109189ENST00000514536D6R9Z4

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363356362023Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1-mediated glycolysis.1
377983012023The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.4
363356362023Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1-mediated glycolysis.1
377983012023The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.4
356376302022MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma.1
356376302022MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma.1
335764372021Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2.4
340295712021Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1.7
335764372021Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2.4
340295712021Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1.7
330294972020USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway.4
330294972020USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway.4
315422322019Ubiquitin-specific peptidase 46 (USP46) suppresses renal cell carcinoma tumorigenesis through AKT pathway inactivation.5
315422322019Ubiquitin-specific peptidase 46 (USP46) suppresses renal cell carcinoma tumorigenesis through AKT pathway inactivation.5
304159512018The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers.25

Citation

Dessen P

USP46 (ubiquitin specific peptidase 46)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54763/usp46-(ubiquitin-specific-peptidase-46)