CROCC (ciliary rootlet coiled-coil, rootletin)

2016-10-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
ROLT,TAX1BP2
FUSION GENES

Other Information

Locus ID:

NCBI: 9696
MIM: 615776
HGNC: 21299
Ensembl: ENSG00000058453

Variants:

dbSNP: 9696
ClinVar: 9696
TCGA: ENSG00000058453
COSMIC: CROCC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058453ENST00000375541Q5TZA2
ENSG00000058453ENST00000445545B1AKD8
ENSG00000058453ENST00000467715A0A087WU09
ENSG00000058453ENST00000467938A0A087WW81

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167670812006The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication.25
230705192012C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.18
294637192018STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles.12
280897742017Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion.5
226109722012The centrosomal protein Tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2.4
296492112018Stable centrosomal roots disentangle to allow interphase centriole independence.2
242406862014The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.1

Citation

Dessen P

CROCC (ciliary rootlet coiled-coil, rootletin)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56628/crocc-(ciliary-rootlet-coiled-coil-rootletin)