BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor)

2017-04-01  

Identity

HGNC
BUD23
LOCATION
7q11.23
LOCUSID
114049
ALIAS
HASJ4442,HUSSY-3,MERM1,PP3381,WBMT,WBSCR22

Other Information

Locus ID:

NCBI: 114049
MIM: 615733
HGNC: 16405
Ensembl: ENSG00000071462

Variants:

dbSNP: 114049
ClinVar: 114049
TCGA: ENSG00000071462
COSMIC: BUD23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071462ENST00000265758O43709
ENSG00000071462ENST00000421304F8VZ18
ENSG00000071462ENST00000421744F8WD87
ENSG00000071462ENST00000423497O43709
ENSG00000071462ENST00000428163F8WD67
ENSG00000071462ENST00000430270F8W1Y1
ENSG00000071462ENST00000430446H7C439
ENSG00000071462ENST00000432522E9PCQ7
ENSG00000071462ENST00000436944B3KR83
ENSG00000071462ENST00000441822F2Z3D9
ENSG00000071462ENST00000442099H7C170
ENSG00000071462ENST00000453316H7C0G4

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
350888872022WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.19
350888872022WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.19
319397352020Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.8
323801882020WBSCR22 confers cell survival and predicts poor prognosis in glioma.15
319397352020Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.8
323801882020WBSCR22 confers cell survival and predicts poor prognosis in glioma.15
305352322019Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation.1
305352322019Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation.1
291338972017WBSCR22 confers oxaliplatin resistance in human colorectal cancer.26
291338972017WBSCR22 confers oxaliplatin resistance in human colorectal cancer.26
253522092015Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 expression levels.4
255251532015WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA.74
258516042015The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.81
262141852015The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway.18
253522092015Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 expression levels.4

Citation

Dessen P

BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56847/bud23-(bud23-rrna-methyltransferase-and-ribosome-maturation-factor)