MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6)
1997-12-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
17q12
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
FUSION GENES
DNA/RNA
Transcription
7.5 and 5 kb mRNA; coding sequence: 3.3 kb
Proteins
Description
1093 amino acids; N- term - 3 Zn fingers (LAP type) and a leucine zipper - C-term; a leucine zipper is a dimerization motif
Localisation
nuclear
Function
transcriptional regulation factor
Homology
with AF10 and BR140, a gene sitting in 3p25
Implicated in
Entity name
Disease
AML and MDS
Cytogenetics
additional anomaly: +8
Hybrid gene
5 MLL - 3 AF17
Fusion protein
N-term AT hook and DNA methyltransferase from MLL fused to the leucine zipper C-term of AF17
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7542910 | 1995 | Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. | Bernard OA et al |
| 8058765 | 1994 | Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. | Prasad R et al |
| 8558942 | 1996 | 11q23 rearrangements in acute leukemia. | Rubnitz JE et al |
| 8977038 | 1996 | Chromosome abnormalities in leukaemia: the 11q23 paradigm. | Young BD et al |
Other Information
Locus ID:
NCBI: 4302
MIM: 600328
HGNC: 7138
Ensembl: ENSG00000275023
Variants:
dbSNP: 4302
ClinVar: 4302
TCGA: ENSG00000275023
COSMIC: MLLT6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000275023 | ENST00000615858 | A0A087WVY1 |
| ENSG00000275023 | ENST00000620609 | Q6P2C6 |
| ENSG00000275023 | ENST00000621332 | P55198 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33063451 | 2020 | MLLT6 maintains PD-L1 expression and mediates tumor immune resistance. | 9 |
| 33063451 | 2020 | MLLT6 maintains PD-L1 expression and mediates tumor immune resistance. | 9 |
| 19864429 | 2009 | AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha. | 31 |
| 19864429 | 2009 | AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha. | 31 |
| 16086288 | 2005 | [Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5]. | 0 |
| 16086288 | 2005 | [Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5]. | 0 |
Citation
Jean-Loup Huret
MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6)
Atlas Genet Cytogenet Oncol Haematol. 1997-12-01
Online version: http://atlasgeneticsoncology.org/gene/7/mllt6-(myeloid-lymphoid-or-mixed-lineage-leukemia-(trithorax-homolog-drosophila)
