BAALC (brain and acute leukemia, cytoplasmic)
2006-02-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France
DNA/RNA
Description
The gene spans over 90kb on plus strand; 8 exons; 3 polyadenylation signals in the 3 untranslated region of exon 8
Proteins
Expression
Transcripts involving exons 1, 6, and 8, or 1, and 8 are found in neurectoderm tissues; BAALC is also expressed in normal early progenitor cells (CD34+) of the hematopoietic tissues: both uncommitted and lineage-committed progenitor cells (lymphoid T- and B-cell progenitors, myeloid and erytroid progenitors); down regulation occurs with cell differentiation; various transcripts are found in leukemic blasts (see above and below); also found expressed in the mesoderm and the muscle in the mouse
Localisation
Cytoplasmic; found adjacent to the cell membrane in the mouse; may be localized to lipid rafts and may play a synaptic role in the rat brain
Homology
No homology with other proteins; the ortholog lacks in lower vertebrates.
Mutations
Somatic
Overexpressed in a subset of acute leukemias
Implicated in
Entity name
1/4 of acute non lymphocytic leukemia (AML) cases and 2/3 of acute lymphocytic leukemia (ALL) case have been found to exhibit high BAALC expression ; no expression in chronic leukemias (e.g. chronic myeloid leukemia (CML)); expression in blast crisis of CML.
Disease
Prognosis
Poor prognosis is associated with BAALC overexpression in AML cases: at 3 yrs, only 35-40% of patients with high BAALC expression were alive; independant risk factor; in particular, BAALC overexpression remains a poor prognostic factor in the absence of FLT3 internal tandem duplication.
Cytogenetics
Patients present with normal karyotypes, with +8, or with various anomalies.
Entity name
Glioblastoma
Note
BAALC in also upregulated in normal astrocytes
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 16418499 | 2006 | BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: prognostic implications. | Baldus CD et al |
| 15604894 | 2005 | Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics. | Marcucci G et al |
| 16376586 | 2006 | Induction of BAALC and down regulation of RAMP3 in astrocytes treated with differentiation inducers. | Moodbidri MS et al |
| 15749074 | 2005 | Baalc, a marker of mesoderm and muscle. | Satoskar AA et al |
| 11707601 | 2001 | BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. | Tanner SM et al |
| 15659234 | 2005 | BAALC 1-6-8 protein is targeted to postsynaptic lipid rafts by its N-terminal myristoylation and palmitoylation, and interacts with alpha, but not beta, subunit of Ca/calmodulin-dependent protein kinase II. | Wang X et al |
Other Information
Locus ID:
NCBI: 79870
MIM: 606602
HGNC: 14333
Ensembl: ENSG00000164929
Variants:
dbSNP: 79870
ClinVar: 79870
TCGA: ENSG00000164929
COSMIC: BAALC
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35429905 | 2022 | BAALC gene expression tells a serious patient outcome tale in NPM1-wild type/FLT3-ITD negative cytogenetically normal-acute myeloid leukemia in adults. | 2 |
| 35429905 | 2022 | BAALC gene expression tells a serious patient outcome tale in NPM1-wild type/FLT3-ITD negative cytogenetically normal-acute myeloid leukemia in adults. | 2 |
| 33242229 | 2021 | Prognostic significance of combined BAALC and MN1 gene expression level in acute myeloid leukemia with normal karyotype. | 1 |
| 33453340 | 2021 | Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia. | 1 |
| 33894142 | 2021 | iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia. | 12 |
| 33242229 | 2021 | Prognostic significance of combined BAALC and MN1 gene expression level in acute myeloid leukemia with normal karyotype. | 1 |
| 33453340 | 2021 | Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia. | 1 |
| 33894142 | 2021 | iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia. | 12 |
| 32129446 | 2020 | Simultaneous changes in expression levels of BAALC and miR-326: a novel prognostic biomarker for childhood ALL. | 7 |
| 32811810 | 2020 | Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC. | 15 |
| 32862286 | 2020 | Allogeneic stem cell transplantation mitigates the adverse prognostic impact of high diagnostic BAALC and MN1 expression in AML. | 0 |
| 32129446 | 2020 | Simultaneous changes in expression levels of BAALC and miR-326: a novel prognostic biomarker for childhood ALL. | 7 |
| 32811810 | 2020 | Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC. | 15 |
| 32862286 | 2020 | Allogeneic stem cell transplantation mitigates the adverse prognostic impact of high diagnostic BAALC and MN1 expression in AML. | 0 |
| 29696374 | 2018 | BAALC and ERG expression levels at diagnosis have no prognosis impact on acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation. | 5 |
Citation
Jean-Loup Huret ; Sylvie Senon
BAALC (brain and acute leukemia, cytoplasmic)
Atlas Genet Cytogenet Oncol Haematol. 2006-02-01
Online version: http://atlasgeneticsoncology.org/gene/739/baalc-(brain-and-acute-leukemia-cytoplasmic)
