Department of Pharmacology, Institute of Biomedical Sciences of the University of São Paulo, São Paulo, Brazil; jorgegdy@icloud.com; jamachadoneto@usp.br
BUB3 is a WD40 protein that belongs to spindle mitotic checkpoint complex, which monitors the chromosome attachment to mitotic (or meiotic) fuse and prevents premature chromosome segregation. Alterations in BUB3 have been associated with chromosomal instability and aneuploidy, but their contribution for cancer development and progression are poorly understood, and appear to differ depending on the type of cancer. The present review contains data on BUB3 DNA, RNA, protein encoded and function.
NCBI: 9184 MIM: 603719 HGNC: 1151 Ensembl: ENSG00000154473
dbSNP: 9184 ClinVar: 9184 TCGA: ENSG00000154473 COSMIC: BUB3
Jorge Antonio Elias Godoy Carlos ; Joao Agostinho Machado-Neto
BUB3 (BUB3 mitotic checkpoint protein)
Atlas Genet Cytogenet Oncol Haematol. 2019-03-01
Online version: http://atlasgeneticsoncology.org/gene/855/deep-insight-explorer/tumors-explorer/js/lib/all.min.js